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Online energy consumption forecast for battery electric buses using a learning-free algebraic method
The value of metagenomic next-generation sequencing in the diagnosis of fever of unknown origin
Fluid structure Interaction analysis for rupture risk assessment in patients with middle cerebral artery aneurysms
Enhanced Grey Wolf Optimization (EGWO) and random forest based mechanism for intrusion detection in IoT networks
Experimental study on the splitting tensile failure of a carbon nanotube-modified fly ash foamed concrete filler
Facial assessment methods for inhibiting glycation and aging effects and the correlation between glycation and aging parameters
Experiences of healthcare professionals returning to work post breast cancer diagnosis in China: A descriptive qualitative study
Networks of pre-diagnostic circulating RNA in testicular germ cell tumour
Abstract Testicular germ cell tumour (TGCT) is a malignancy with known inherited risk factors, affecting young men. We have previously identified several hundred differentially abundant circulating RNAs in pre-diagnostic serum from TGCT cases compared to healthy controls. In this study, we performed Weighted Gene Co-expression Network Analysis (WGCNA) on mRNA and miRNA data from these samples. Central genes (hub genes) enriched functional pathways, and regulatory feature prediction were identified for all TGCT subtypes together and according to histology. The TGCT susceptibility genes TEX14 , NARS2 , and G3BP2 , were identified as hub genes in both seminoma and non-seminoma networks. We also identified UBCA1 , RCC1 , FMR1 , OAS3 , and UBE2W as hub genes associated with TGCT. The genes OAS3 and UBE2W have previously been associated with testicular dysgenesis. Furthermore, network module analysis indicated transcription factors for oestrogen-related receptors to have a potential role during development of TGCT. The overlap between mRNA network hub genes and TGCT susceptibility genes indicates a common role in TGCT development.
Evaluating historical changes in a mussel bed community in northern California
Abstract Marine foundation species are increasingly impacted by anthropogenic stressors, driving a loss of diversity within these critical habitats. Prior studies suggest that species diversity within mussel beds has declined precipitously in southern California, USA, but it is unclear whether a similar loss has occurred farther north. Here, we resurvey a mussel bed community in northern California first sampled in 1941 to evaluate changes in diversity after 78 years. More broadly, we explore the value and potential challenges of using imperfect historical data to assess community changes. Our 2019 survey documented 90 species/taxa across 10 phyla. The majority of species (~ 72%) were common to all replicate plots, suggesting that variation in species diversity over small spatial scales was unlikely to mask temporal changes. In contrast to results from southern California, we observed no decline in species diversity between timepoints. However, there were shifts in species composition, with an increase in the abundance of southern species and a decrease in northern species, consistent with warming observed at a nearby shoreline site. Overall, our findings are an encouraging sign for the health of this mussel bed community in northern California and illustrate how non-traditional data can contribute to assessments of long-term ecological change.
Visit-to-visit lipid variability on long-term major adverse cardiovascular events: a prospective multicentre cohort from the CORE-Thailand registry
High efficiency high gain low side lobe level and slant polarization monopulse antenna using cavity backed slot coupled patch antenna
Predicting the impact of dynamic global urban expansion on urban soil organic carbon
Profile of Bruce E. Tabashnik
Fig abscission as a defense mechanism of Ficus trees against parasitism by non-pollinating fig wasps
Abstract How does the fig tree Ficus benguetensis protect its investment in the production of figs and pollinating fig wasps against parasitism from non-pollinating fig wasps? This study documents a previously overlooked defense mechanism: fig abscission—the natural shedding of the fig fruit as a defense mechanism. Our bagging experiments showed that both the absence of pollination and high parasitism levels lead to the abortion of F. benguetensis figs, with positive correlations between parasitism levels, increased abscission rates, and decreased pollinator production. Moreover, we found that high parasitism corresponds to shortened fig development periods until abscission, while medium parasitism levels result in fewer pollinators. Our findings suggest that abscission may function as a resource conservation strategy, as most of the tree’s investment in the figs occurs post-pollination. This study uncovers for the first time the use of fig abscission as a unique defense against non-pollinating fig wasp parasites, broadening our understanding of plant defense mechanisms within mutualistic interactions.
Reply to Kaestner et al.: Activation of PIEZO1 is not significant for the passage of red blood cells through biomimetic splenic slits
The impact of metabolic syndrome on hepatocellular carcinoma: a mendelian randomization study
Expression of some circulating microRNAs as predictive biomarkers for prognosis and treatment response in glioblastoma
Abstract Glioblastoma multiforme (GBM) is the most prevalent, treatment-resistant, and fatal form of brain malignancy. It is characterized by genetic heterogeneity, and an infiltrative nature, and GBM treatment is highly challenging. Despite multimodal therapies, clinicians lack efficient prognostic and predictive markers. Therefore, new insights into GBM management are urgently needed to increase the chance of therapeutic success. Circulating miRNAs (miRs) are important regulators of cancer progression and are potentially useful for GBM diagnosis and treatment. This study investigated how miR-29a, miR-106a, and miR-200a affect the prognosis of GBM patients. This study was conducted on 25 GBM patients and 20 healthy volunteers as a control group. The expression levels of target miRs were analyzed pre- and post-treatment using qRT-PCR and evaluated in relation to both clinical GBM criteria and the patient’s survival modes. The diagnostic efficacy of target miRs was assessed using the receiver operating characteristic (ROC) curve. MiRs levels showed significant differences among the enrolled participants. All investigated miRs were significantly elevated in GBM patients with non-frontal lesions. Only miR-200a showed a significant difference in GBM patients older than 60 years with a tumor size ≥ 5 mm. Regarding miR-106a, a significant difference was detected based on the surgical strategy and use of an Eastern Cooperative Oncology Group (ECOG) performance status equal to 2. For miR-29a, a significant upregulation was detected according to the surgical strategy. All post-treatment miRs levels in GBM patients were significantly downregulated. In conclusion, circulating miRs revealed a significant role in predicting GBM patient treatment outcomes providing valuable insights for personalized therapeutic strategies.