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Spatiotemporal variation of snowpack depths in Northeast China and its mechanisms from 2025 to 2099 based on CMIP6 models
Prestimulus functional connectivity reflects attention orientation in a prospective memory task: A magnetoencephalographic (MEG) study
Prospective Memory (PM) is the ability to encode an intention in memory and retrieve it at the right time in the future. After the intention is formed, it must be maintained in memory while simultaneously monitoring the environment until the occurrence of the stimulus associated with its retrieval. Therefore, monitoring and maintenance processes must work in conjunction to subserve PM processing (monitoring/maintenance phase). Several brain regions play a role in PM, such as the anterior prefrontal cortex, inferior parietal lobules, and precuneus. Notably, these regions belong to different brain networks and are differently involved depending on the memory and attentional requests of the PM task. In this study, we investigate the neural bases of PM from a network perspective, using functional connectivity (FC) analysis to identify the networks involved in the attentional and memory mechanisms underlying PM. To this end, we analyzed MEG data collected in two different PM conditions, enhancing either the monitoring (i.e., attention) or the maintenance (i.e., memory) loads of the PM task. To disentangle the neural correlates of these mechanisms from other processes occurring after stimulus presentation, the analysis focused on the prestimulus time window (monitoring/maintenance phase). The monitoring-load condition was characterized by increased inter-network FC of the Dorsal Attention Network (DAN) in the alpha band, a marker of increased top-down monitoring. In contrast, the maintenance-load condition was associated with increased connectivity of the Ventral Attention Network (VAN) with the FrontoParietal Control and the Default-Mode Networks (FPCN and DMN, respectively). Additionally, response times were found to correlate with prestimulus alpha connectivity of different networks in the two conditions. These differences in connectivity within and between networks support the hypothesis that different networks (DAN, or VAN and DMN) and mechanisms (top-down or bottom-up, respectively) are involved in PM processing depending on the features of the PM task.
Unsupervised translation of vascular masks to NIR-II fluorescence images using Attention-Guided generative adversarial networks
Historical precipitation and flood damage in Japan: functional data analysis and evaluation of models
The future increase of large-scale weather disasters resulting from the increased frequency of extreme weather events caused by climate change is a matter of concern. Predicting future flood damage through statistical analysis requires accurate modeling of the relationship between historical precipitation and flood damage. An analysis that considers precipitation as a time series may be appropriate for this purpose. Functional data analysis was applied to model the relationship between historical daily precipitation and daily flood damage for river basins in the Kanto and Koshin regions of Japan. Flood damage statistics from the national government and 1-km grid past precipitation data from the National Agriculture and Food Research Organization were used. The models obtained through the functional data analysis were more accurate than those derived from the simple linear regression without considering the time series of precipitation. The new models were also about four times more accurate in estimating the annual sum of flood damage, compared to the flood damage of each flood event. The accuracy of prediction was higher in recent years than in earlier years of the study period (1993–2020). The results showed that the influence of precipitation on flood damage was more apparent in recent years. This findings may imply that the progress of the river development project and the resulting improvement of the structures along the river have indirectly affected levels of flood damage associated with levels of precipitation.
Tuning TCR complex recruitment to the T cell antigen coupler (TAC) enhances TAC-T cell function
Association of myopia and parapapillary choroidal microvascular density in primary open-angle glaucoma
Background/Aims To compare parapapillary choroidal microvascular (PPCMv) densities between myopic eyes with and without glaucoma. Methods In this retrospective study, OCTA images (4.5 × 4.5 mm) were obtained using a commercial spectral-domain OCTA system. PPCMv density was calculated in inner and outer annuli using customized software. Marginal model of generalized estimating equations was established to adjust for confounding factors and intraclass correlations. Results This study included 35 myopic eyes with glaucoma (MG), 96 non-myopic eyes with glaucoma (NMG) matched for visual field mean deviation, 37 myopic eyes without glaucoma (MNG), and 73 control eyes from three tertiary centers. The participant ages were (mean [standard deviation, SD]) 57.43 [11.49], 60.40 [10.07], 52.84 [9.35], and 54.74 [12.07] years. Inner and outer annular PPCMv densities (mean [SD]) decreased in the following order: control (0.15 [0.04] and 0.12 [0.04]), MNG (0.14 [0.08] and 0.12 [0.08]), NMG (0.09 [0.05] and 0.07 [0.04]), and MG (0.09 [0.04] and 0.07 [0.03]). The mean differences in PPCMv density between glaucoma groups (NMG and MG) and the control group (mean difference [95% confidence interval]) were −0.06 (−0.08 to −0.04, P < 0.001 for inner whole annular PPCMv density in NMG vs control) and −0.07 (−0.10 to −0.04, P < 0.001 for inner whole annular PPCMv density in MG vs control), consistent across all regions of interest (ROIs). No significant interaction was observed between glaucoma and myopia after adjustment for potential confounders (P > 0.112). Conclusions Parapapillary choroidal microvascular density attenuation tends to be greater in eyes with glaucoma than in eyes with myopia.
Neonatal and maternal dietary interventions driving microbiota and functionality in piglet gut compartments
Effects of electroporation on Acanthamoeba Polyphaga
Background Species of the genus Acanthamoeba spp. are ubiquitous and can cause Acanthamoeba keratitis (AK), a serious corneal infection. Due to the toxicity and ineffectiveness of currently available prolonged therapies, we investigated electroceutical treatment aimed at facilitating the permeation of molecules through the membrane of cysts and trophozoites, which allows for faster elimination of the parasite. Methods Cysts and trophozoites of Acanthamoeba polyphaga (ATCC® 30461TM) were exposed in vitro to an electric field with intensities of 2,000 volts and 2,500 volts. Viability after electroporation was assessed by the exclusion method with 0.4% trypan blue dye, while permeabilization was assessed by fluorescence microscopy using propidium iodide (PI), since both are impermeable to the membrane of viable and intact cells. The images were acquired on a Nikon Eclipse TI-U microscope and analyzed using ImageJ software. Results With regard to viability, 40% of the trophozoites electroporated at 2,000 V and 42% of those electroporated at 2,500 V were lost, while for cysts the loss was 13% and 16% respectively. Considering permeabilization, 55% of trophozoites and cysts were permeabilized at 2,000 V (p ≤ 0.05); and 59% at 2,500 V for both (p ≤ 0.05). Values of p < 0.05 were considered statistically significant. Conclusion The voltages tested were effective for both cysts and trophozoites, since the percentages of permeabilization were close, with no statistical significance between them, only with the control groups. These results suggest the possibility that an electroceutical treatment could be applied as a complement to the standard treatment for AK.
Exploring the nexus between hypothyroidism and metabolic dysfunction-associated steatotic liver disease: a UK biobank cohort study
Prevalence and determinants of effective breastfeeding technique among early postpartum mothers in Fuzhou, China: A cross-sectional study
Background Breastfeeding technique (BFT) is determined by the mother’s and infant’s positioning, the infant’s attachment to the breast, and the infant’s suckling behavior. Understanding breastfeeding mothers’ skills is crucial for clinical practice and for designing interventions to improve breastfeeding practices. This study aimed to determine the prevalence and determinants of effective BFT among early post-partum mothers. Methods We conducted a cross-sectional study among 415 early post-partum mothers in Fuzhou, China. Participants were recruited using a systematic random sampling technique. Data were collected using a self-administered questionnaire and a standardized observational checklist (WHO B-R-E-A-S-T Feed observation form). Descriptive statistics were used to assess the prevalence of effective BFT, and logistic regression was applied to identify its determinants. Results The overall prevalence of effective BFT was 70.4%. After adjusting for potential confounders, the prevalence ratio (PR) of effective BFT was greater among participants with college (PR = 1.20) and postgraduate education (PR = 1.41) compared to those with a technical education or lower. Participants who attended antenatal care (ANC) (PR = 1.04) and those with BFT knowledge (PR = 1.37) were more likely to practice effective BFT compared to participants who did not attend ANC and without such knowledge respectively. Similarly, those who received BFT counseling during pregnancy or immediately after delivery were 25% and 30%, respectively, more likely to practice effective EBT than those who did not. Conversely, experiencing breast problems was associated with a 42% lower likelihood of practicing effective BFT than those without breast problems. Conclusion Effective BFT is prevalent among early postpartum mothers in Fuzhou, China, with education level, antenatal care attendance, knowledge, and counseling playing significant roles in its practice. Efforts to improve breastfeeding outcomes should focus on enhancing educational interventions and providing targeted counseling during pregnancy and the immediate postpartum period, while addressing breast health issues to mitigate their impact on breastfeeding effectiveness.
Antinutritional and insecticidal potential of Chenopodium quinoa saponin rich extract against Tribolium castaneum (Herbst) and its action mechanism
Optimizing success rate with Nonlinear Mapping Control in a high-performance raspberry Pi-based light source target tracking system
This study addresses the limitations of linear mapping in two-dimensional gimbal control for moving target tracking, which results in significant control errors and slow response times. To overcome these issues, we propose a nonlinear mapping control method that enhances the success rate of light source target tracking systems. Using Raspberry Pi 4B and OpenCV, the control system performs real-time recognition of rectangular frames and laser spot images. The tracking system, which includes an OpenMV H7 Plus camera, captures and processes the laser spot path. Both systems are connected to an STM32F407ZGT6 microcontroller to drive a 42-step stepper motor with precise control. By adjusting the parameter c of the nonlinear mapping curve, we optimize the system's performance, balancing the response speed and stability. Our results show a significant improvement in control accuracy, with a miss rate of 3.3%, an average error rate of 0.188% at 1.25 m, and a 100% success rate in target tracking. The proposed nonlinear mapping control method offers substantial advancements in real-time tracking and control systems, demonstrating its potential for broader application in intelligent control fields.
Nightmare distress mediated the correlation between autobiographical memory specificity and depression
In this study, we explored whether nightmare distress mediated the correlation between autobiographical memory specificity and depression. 112 participants provided their most recent dreams that happened within one month, and finished some scales that measured depression, autobiographical memory specificity, and nightmare distress. In line with our hypothesis, nightmare distress was the mediator that played a role in the relationship between autobiographical memory specificity and depression. In addition, we found that both nightmare distress and autobiographical memory specificity were correlated with the impact of a dream on one’s life story. By contrast, contrary to our hypothesis, we did not find any correlation between autobiographical memory specificity, or nightmare distress, and dream bizarreness. Potential implications from these results were discussed.
2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health. The AHA Heart Disease and Stroke Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, brain health, complications of pregnancy, kidney disease, congenital heart disease, rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary heart disease, cardiomyopathy, heart failure, valvular disease, venous thromboembolism, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). METHODS: The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2025 AHA Statistical Update is the product of a full year’s worth of effort in 2024 by dedicated volunteer clinicians and scientists, committed government professionals, and AHA staff members. This year’s edition includes a continued focus on health equity across several key domains and enhanced global data that reflect improved methods and incorporation of ≈3000 new data sources since last year’s Statistical Update. RESULTS: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. CONCLUSIONS: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.
Effect of rabbit gastrointestinal stasis (RGIS) on the fecal microbiota of pet rabbits (Oryctolagus cuniculus)
Rabbit (Oryctolagus cuniculus) gastrointestinal stasis syndrome (RGIS) is defined as reduced motility of any part of the digestive tract that can lead to impaction and death if left untreated. This study aimed to describe the effect of RGIS on the fecal microbiota of client-owned pet rabbits. Fecal samples from healthy rabbits and rabbits displaying RGIS were obtained and the symptomology of the rabbits was recorded along with any medical intervention. The health outcomes were as follows: 1) Healthy rabbits (Healthy, n = 21), and 2) Rabbits that displayed symptoms of RGIS, were treated, and recovered (RGIS, n = 22). The fecal samples were analyzed using 16S rRNA and 18S rRNA gene amplicon sequencing to characterize the bacterial and eukaryotic microbial communities, respectively. In the 16S rRNA amplicon dataset, two bacterial genera were found in higher abundance in rabbits with RGIS: Clostridium sensu stricto 1 and an unclassified genus in the Enterobacteriaceae family. Likewise, five genera were found in higher abundance in healthy rabbits. The yeast Cyniclomyces guttulatus dominated the eukaryotic microbiota in all rabbits. RGIS is one of the most common issues in clinical practice. This study is the first to perform detailed characterization of the effects of RGIS on the domestic rabbit’s bacterial and eukaryotic fecal microbiota. The results demonstrate a significant change in the relative abundance of seven bacterial genera associated with RGIS. Future research is necessary to elucidate the potential role of these microorganisms in RGIS. In the long-term, treatments targeting the restoration of the physiological gastrointestinal microbiota should be developed.
Personalized Heart Digital Twins Detect Substrate Abnormalities in Scar-Dependent Ventricular Tachycardia
BACKGROUND: Current outcomes from catheter ablation for scar-dependent ventricular tachycardia (VT) are limited by high recurrence rates and long procedure durations. Personalized heart digital twin technology presents a noninvasive method of predicting critical substrate in VT, and its integration into clinical VT ablation offers a promising solution. The accuracy of the predictions of digital twins to detect invasive substrate abnormalities is unknown. We present the first prospective analysis of digital twin technology in predicting critical substrate abnormalities in VT. METHODS: Heart digital twin models were created from 18 patients with scar-dependent VT undergoing catheter ablation. Contrast-enhanced cardiac magnetic resonance images were used to reconstruct finite-element meshes, onto which regional electrophysiological properties were applied. Rapid-pacing protocols were used to induce VTs and to define the VT circuits. Predicted optimum ablation sites to terminate all VTs in the models were identified. Invasive substrate mapping was performed, and the digital twins were merged with the electroanatomical map. Electrogram abnormalities and regions of conduction slowing were compared between digital twin–predicted sites and nonpredicted areas. RESULTS: Electrogram abnormalities were significantly more frequent in digital twin–predicted sites compared with nonpredicted sites (468/1029 [45.5%] versus 519/1611 [32.2%]; P <0.001). Electrogram duration was longer at predicted sites compared with nonpredicted sites (82.0±25.9 milliseconds versus 69.7±22.3 milliseconds; P <0.001). Digital twins correctly identified 21 of 26 (80.8%) deceleration zones seen on isochronal late activation mapping. CONCLUSIONS: Digital twin–predicted sites display a higher prevalence of abnormal and prolonged electrograms compared with nonpredicted sites and accurately identify regions of conduction slowing. Digital twin technology may help improve substrate-based VT ablation. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT04632394.
The ancient and helical architecture of Elasmobranchii’s spermatozoa enables progressive motility in viscous environments
Subclass Elasmobranchii belongs to an old evolutionary class of Chondrichthyes that diverged 450 mya, presenting a wide diversity of reproductive strategies while preserving the ancient mode of internal fertilization. Despite such evolutionary success, many species in this group are at serious risk of extinction. Understanding the principles of sperm progressive motility and physiology of such an ancient group of vertebrates is crucial for advancing future assisted reproductive techniques to safeguard this species and for deepening our understanding of the evolution of reproduction. Elasmobranchii species possess big spermatozoa (compared to bony fishes) with an elongated helical head and tail similar to one currently existing (but later diverged) in birds, reptiles, and amphibians, which can be considered an evolutionary ancient. These structures may be associated with the necessity to penetrate viscous ovarian fluid or the jelly layer of eggs, suggesting environmental viscosity as the driving pressure shaping large-sized sperm heads into helical shapes through evolution. We observed spermatozoa motility with high-speed video microscopy to capture sperm and flagellar motion in three Elasmobranchii species: the freshwater ray Potamotrygon motoro, the marine skate Raja asterias and the shark Scyliorhinus canicula. We investigated the effect of viscosity on spermatozoa motility parameters and its ability to break free from spermatozeugmata, move progressively, and perform directional changes. After 20 min of observation, the spermatozeugmata conserved their structure in a low viscosity media of 1000 mOsm/kg osmolality. In comparison, no remaining structure of spermatozeugmata could be found in high-viscosity media with 2% methylcellulose (MC) in all three species due to progressive spermatozoa motion. We find that spermatozoa’s unique helical head-to-flagellum architecture is specific to promote locomotion in high-viscosity fluid; they cannot move progressively in low viscosity. The highest velocity for shark sperm was observed at 0.75% MC and 1% MC for ray and skate sperm. Viscosity stabilizes the flagellar propagation, producing rotational forces and allowing the helical head to “screw” into the media. Our observations suggest that the surrounding viscosity is critical to allowing spermatozoa progressive motility and enabling spermatozoa to control direction via newly observed head buckling in high viscosity. As such, the viscosity may be a key element controlling and regulating sperm performance and navigation during fertilization in the Elasmobranchii species.
New Stroke Awareness Campaign Focuses on Hispanic and Latino People: Culturally Relevant and Spanish-Language Resources Aim to Improve Health Knowledge and Equity
Sustainable care: How CSR shapes wellbeing in healthcare organizations in Beijing, Shanghai, and Guangzhou
This article investigates the link between corporate social responsibility (CSR) perceptions of employees and employee burnout, from a sustainable development point of view, in the healthcare system of China. It fills the void in conventional literature by analyzing the indirect effect of CSR on the health and well-being of health workers aligning with SDGs focused on health and wellbeing. To be able to address the crux of healthcare professionals’ burnout which can have far-reaching negative consequences for individual welfare and healthcare delivery, this research explores the linkages between CSR perceptions, employee burnout, happiness, psychological safety, and altruistic behavior. Data were obtained from 392 health care workers in three Chinese cities through a thrice-administered questionnaire that measures CSR perceptions of employees, burnout levels, happiness, safety perceptions, and altruistic motivations. It is seen that results show a strong link between CSR perceptions of employees and burnout reduction. Furthermore, the happiness and psychological safety of workers were expressed as mediators, with altruism playing the role of moderator. The above points highlight the need to adopt CSR strategies to promote employee well-being and combat burnout in the healthcare sector, which plays a vital role in global initiatives to attain SDGs related to good health and well-being, and sustainable development. Additionally, this research increases the debate on employee burnout based on their organization’s CSR perceptions and positive psychology theory as a lens, bringing up CSR as the key factor in the achievement of sustainable development and the improvement of well-being within healthcare settings.