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Choice of props for courtship dancing in estrildid finches

Key factors in coastal village’s street planning for marine climate adaptation

Generation of perthiyl radicals for the synthesis of unsymmetric disulfides

It’s dark under the lamp? The moderating role of executives’ accounting competence on relationship between goodwill impairment signal and goodwill impairment

This study examines the influence of executives’ accounting competence on relationship between goodwill impairment signal and goodwill impairment, considering the perspective of performance compensation commitment. The research employs an empirical research method and utilizes a sample of A-share listed companies in China that have signed performance compensation commitment agreements from 2007 to 2022. I found that the executives’ accounting competence weakens the relationship between goodwill impairment signal and goodwill impairment. The stronger the executives’ accounting competence is, the weaker the goodwill impairment signal is, that is, the probability of the goodwill impairment is lower and the scale of goodwill impairment is smaller. Further research shows that the negative effect of executives’ accounting competence is more significant when the performance compensation commitment of the target assets is between 80% and 100%. Through heterogeneity analysis, it is found that the negative effect of executives’ accounting competence will be suppressed when the sample is in the period of equity incentive or the auditor audits the key issues of goodwill impairment. The research in this paper not only enriches the relevant literature on the characteristics of executives, but also discusses the subsequent measurement of goodwill, which is also conducive to promoting the formulation of accounting standards and assisting the supervision of capital markets, and has important theoretical and practical significance.

Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma

Patella height ratios diagnose the same healthy knees differently

Abstract Our study aims to investigate if the ratios proposed by Insall-Salvati and Caton-Deschamps follow the theory of normal distribution levels in a healthy population. 434 skeletal mature, healthy knees were obtained from a CT-scan-based modelling system (SOMA). Patellae height ratios were measured using the Insall-Salvati ratio and the Caton-Deschamps index. The patella height ratios of the sample population were plotted on a quantile plot and diagnosed as patella alta, baja or normal using the original ratio definitions. The study population patella height values at the 95th, 98th and 5th centiles were identified and compared to those described as alta or baja by Insall-Salvati and Caton-Deschamps. This meant that if the patient had patella alta, this would be defined as a ratio of ≥ 1.2 and hypothesised that this would align at the 98th centile of the study population, whilst if diagnosed as patella baja (≤ 0.74), this should align at the 5th centile of the population. The inter-rater reliability of both ratios was calculated using kappa statistics. Two authors made all calculations and compared them for consistency using the intraclass correlation coefficient. For the Insall-Salvati ratio, the study population’s value at the 98th centile was equivalent to what Insall-Salvati describes as alta, a ratio of ≥ 1.2. In the study population, patients are overdiagnosed if using the Insall-Salvati ratio as patella baja ≤ 0.74, as the value at the 5th centile in the study population was 0.59. Using the Caton-Deschamps index, the 95th centile was 1.3, higher than the patella alta ratio determined by Caton as a ratio ≥ 1.2. Using Caton-Deschamps, patients are being underdiagnosed if utilising a patella baja ratio of ≤ 0.6. In our population, the 5th centile was 0.75. The two ratios had a kappa coefficient of 0.01, which indicates poor inter-rater reliability. Depending on the ratio used, caton-Deschamps and Insall-Salvati ratios diagnose patients as alta or baja differently. The current patella height ratios have originated from very small, select population samples. The future of patella height discussion should begin with data representing large populations. Then, we can discuss the upper and lower limits of abnormality.

Degradation bottlenecks and resource competition in transiently and stably engineered mammalian cells

Abstract Degradation tags, otherwise known as degrons, are portable sequences that can be used to alter protein stability. Here, we report that degron-tagged proteins compete for cellular degradation resources in engineered mammalian cells leading to coupling of the degradation rates of otherwise independently expressed proteins when constitutively targeted human degrons are adopted. We show the effect of this competition to be dependent on the context of the degrons. By considering different proteins, degron position and cellular hosts, we highlight how the impact of the degron on both degradation strength and resource coupling changes, with identification of orthogonal combinations. By adopting inducible bacterial and plant degrons we also highlight how controlled uncoupling of synthetic construct degradation from the native machinery can be achieved. We then build a genomically integrated capacity monitor tagged with different degrons and confirm resource competition between genomic and transiently expressed DNA constructs. This work expands the characterisation of resource competition in engineered mammalian cells to protein degradation also including integrated systems, providing a framework for the optimisation of heterologous expression systems to advance applications in fundamental and applied biological research.

Development and validation of trigger tools in primary care: A scoping review

In primary care, trigger tools have been utilized to evaluate and identify patient safety events. The use of trigger tools could help clinicians and patients detect adverse events in a patient’s medical record. Due to a lack of research on the process development of trigger tools in primary care, the purpose of this scoping review is to investigate the trigger development and validation process in primary care settings. A scoping review methodology was used to map the published literature using the Joanna Briggs Methodology of performing scoping review. We considered only studies published in English in the last five years and included both qualitative and quantitative study designs. The final review included five articles. The primary care and combined primary-secondary care studies are included to gain more knowledge in the process development and validation of trigger tools. The trigger tool development process begins with clearly defining the triggers, which are then programmed into a combined computerized algorithm. The validation process was then carried out in two steps by both physician and non-physician experts for content and concurrent validity. The sensitivity, specificity, and positive predictive value (PPV) of the final algorithm were critical in determining the validity of each trigger. This study provided a comprehensive guide to developing trigger tools, emphasizing the importance of precisely defining triggers through a thorough literature review and dual validation process. There were similarities in the development and validation of trigger tools across primary care and hospital settings, allowing primary care to learn from hospital settings.

A novel electrochemical sensor for the determination of cadmium ions based on nitrogen-enriched carbon modified electrode

Development and construction of a portable wind tunnel for investigating wind erosion through the application of photogrammetry techniques

AbstractClimate change is one of the most crucial issues in human society such that if it is not given sufficient attention, it can become a great threat to both humans and the Earth. Due to global warming, soil erosion is increasing in different regions. Therefore, this issue will require further investigation and the use of new tools. In this paper, a portable wind tunnel was designed and built for wind erosion studies using photogrammetry, which is a novel technique. This instrument consists of a working section, a fan, a portable voltage source inverter to control its angular speed, and a honeycomb to straighten the air flow in the working section. The eroded volume of soil is measured using photogrammetry by producing two 3D models and point clouds before and after the soil erosion test and calculating their volume changes. The results show that a 0.175 mm check distance precision is achievable under convergent imaging and with sufficient number of accurate control points which this value indicates the discrepancy between the anticipated and measured lengths of all the check distances. In addition, the features of this portable wind tunnel guarantee its easy portability, and its transparency enables the measurement of the threshold friction velocity. Additionally, this instrument, as an invention, has been registered at the Intellectual Property Center of Iran.

Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons

The Scania Accelerated Intermittent Theta-burst Implementation Study (SATIS)–Lessons from an accelerated treatment protocol

Background and objective The Scania Accelerated Intermittent Theta-burst Implementation Study (SATIS) aimed to investigate the tolerability, preliminary effectiveness, and practical feasibility of an accelerated intermittent theta burst stimulation (aTBS) protocol in treating depression. Methods We used an open-label observational design, recruiting 20 patients (aged 19–84 years) from two public brain stimulation centers in Sweden. During the five-day treatment period and at a follow-up visit after 30 days we closely monitored adverse events and collected self-rated side effect data. Objective (MADRS, CGI) and subjective (MADRS-S) measures of symptoms and functioning (EQ-5D) were also assessed. Feasibility was evaluated using direct patient ratings combined with a qualitative approach evaluating staff experience. Results All patients reported adverse events at some point, the most common being headache (18/20 patients), but they were generally transient. MADRS scores decreased from 28.4 (min = 17, max = 38. SD = 6.9) at baseline to 20.0 (min = 1, max = 42. SD = 11.6) after the last day of treatment. 25% (n = 5) met the response criteria, with a mean time to response of 2.2 days (min = 1, max = 3. SD = 1.1). The practical arrangements surrounding this new treatment proved challenging for the organization, but patients reported few practical problems. Conclusion SATIS provided further insights into the potential benefits and challenges associated with aTBS protocols. Effectiveness and drop-out rates were comparable to national data of conventional iTBS, but with a markedly faster time to response. More resources were required than anticipated, increasing the clinical workload.

A lightweight weed detection model for cotton fields based on an improved YOLOv8n

Optimization, characterization, and GC-MS analysis of recycled used engine oil by solvents and adsorbent extraction

Telomere-to-telomere DNA replication timing profiling using single-molecule sequencing with Nanotiming

Abstract Current temporal studies of DNA replication are either low-resolution or require complex cell synchronisation and/or sorting procedures. Here we introduce Nanotiming, a single-molecule, nanopore sequencing-based method producing high-resolution, telomere-to-telomere replication timing (RT) profiles of eukaryotic genomes by interrogating changes in intracellular dTTP concentration during S phase through competition with its analogue bromodeoxyuridine triphosphate (BrdUTP) for incorporation into replicating DNA. This solely demands the labelling of asynchronously growing cells with an innocuous dose of BrdU during one doubling time followed by BrdU quantification along nanopore reads. We demonstrate in S. cerevisiae model eukaryote that Nanotiming reproduces RT profiles generated by reference methods both in wild-type and mutant cells inactivated for known RT determinants. Nanotiming is simple, accurate, inexpensive, amenable to large-scale analyses, and has the unique ability to access RT of individual telomeres, revealing that Rif1 iconic telomere regulator selectively delays replication of telomeres associated with specific subtelomeric elements.

Research on the risk spillover effect between China’s national carbon emissions trading market and crude oil futures market

The development of China’s National Carbon Market has strengthened the inherent link between the carbon market and the broader energy market, providing a potential for cross-market risk transmission resonance. Studying the risk spillover effects between China’s National Carbon Market and the crude oil futures market is of significant practical importance, both in terms of carbon market development and carbon risk management. Based on the Maximal Overlap Discrete Wavelet Transform (MODWT), the price series are decomposed across multiple scales, and the risk spillover effects between the carbon market and the crude oil futures market are examined from both the time domain and the frequency domain. Methods such as wavelet energy decomposition, wavelet correlation, lead-lag analysis, and wavelet coherence are used to explore the mean spillover effects and volatility spillover effects (collectively referred to as risk spillover effects) across various scales. The study finds that China’s National Carbon Market exhibits a clear compliance-driven effect, with relatively low market liquidity. The crude oil futures market experiences frequent price fluctuations, primarily driven by long-term factors. In the time domain, the risk transmission resonance between the carbon market and the crude oil futures market is high, with significant positive correlations observed at the D1 to D4 scales, and noticeable mean spillover effects. In the frequency domain, at the D3 to D4 scales, the carbon market and the crude oil futures market exhibit similar volatility frequencies, indicating strong volatility spillover effects. Based on these findings, it is recommended that the trading volume of the carbon market be gradually increased to improve market liquidity. Furthermore, the risk monitoring and early warning mechanisms of China’s National Carbon Market should be improved. For carbon-emitting companies, enhancing awareness of carbon asset management and making informed investment and hedging decisions based on the correlation between the two markets is crucial.

Biological, environmental, and psychological stress and the human gut microbiome in healthy adults

AbstractEmerging research suggests that the gut microbiome plays a crucial role in stress. We assess stress-microbiome associations in two samples of healthy adults across three stress domains (perceived stress, stressful life events, and biological stress /Respiratory Sinus Arrhythmia; RSA). Study 1 (n = 62; mean-age = 37.3 years; 68% female) and Study 2 (n = 74; mean-age = 41.6 years; female only) measured RSA during laboratory stressors and used 16S rRNA pyrosequencing to classify gut microbial composition from fecal samples. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States was used to predict functional pathways of metagenomes. Results showed differences in beta diversity between high and low stressful life events groups across both studies. Study 1 revealed differences in beta diversity between high and low RSA groups. In Study 1, the low perceived stress group was higher in alpha diversity than the high perceived stress group. Levels of Clostridium were negatively associated with RSA in Study 1 and levels Escherichia/Shigella were positively associated with perceived stress in Study 2. Associations between microbial functional pathways (L-lysine production and formaldehyde absorption) and RSA are discussed. Findings suggest that certain features of the gut microbiome are differentially associated with each stress domain.

MIL-53(Al)-derived bimetallic Pd–Co catalysts for the selective hydrogenation of 1,3-butadiene at low temperature

Integrating genetic subtypes with PET scan monitoring to predict outcome in diffuse large B-cell lymphoma

The impact of village heads’ educational levels on adolescent academic performance: Evidence from rural China

This study investigates the relationship between the educational level of village heads and the academic performance of adolescents, using data from the China Family Panel Studies (CFPS). The analysis reveals that village chiefs with well-educated significantly enhance the academic outcomes of adolescents within their communities. This positive effect remains robust even after controlling for endogeneity through instrumental variables and conducting various robustness checks. Further investigation shows that these well-educated village leaders contribute to an increased provision of public goods, thereby improving the village’s external environment, which in turn supports academic performance. Additionally, well-educated village chiefs serve as role models within the community’s social network, positively influencing parental educational aspirations and enhancing adolescents’ academic results. Notably, the impact of well-educated village chiefs is more pronounced among girls and adolescents from low-income families, underscoring its significance in promoting gender equity in education and breaking cycles of intergenerational poverty.