Browse Articles

FDA approves next-generation triple therapy for cystic fibrosis

Nature Reviews Drug Discovery Asher Mullard Feb 01, 2025 DOI: 10.1038/d41573-025-00008-y

Sufentanil enhances the cortical neurogenesis of rats with traumatic brain injury via PI3K/AKT signal pathway

Scientific Reports Wei Gu, Mimi Wu, Ruocui Zhang et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88344-2

Inhibition of L-threonine dehydrogenase from Trypanosoma cruzi reduces glycine and acetate production and interferes with parasite growth and viability

Journal of Biological Chemistry Jessica do Nascimento Faria, Amanda G. Eufrásio, Michelle Fagundes et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2024.108080

Cough suppressant reverses lung scarring

Nature Reviews Drug Discovery Sarah Crunkhorn Feb 01, 2025 DOI: 10.1038/d41573-025-00006-0

The sex differences in diseases progression and prognosis among persons with HIV and HBV coinfection

Scientific Reports Rongrong Yang, Qianhui Chen, Fangzhou Jiao et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88530-2

Menaquinone-specific turnover by Mycobacterium tuberculosis cytochrome bd is redox regulated by the Q-loop disulfide bond

Journal of Biological Chemistry Tijn T. van der Velden, Kanwal Kayastha, Caspar Y.J. Waterham et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2024.108094

Sodium channel blocker reduces skin inflammation

Nature Reviews Drug Discovery Sarah Crunkhorn Feb 01, 2025 DOI: 10.1038/d41573-025-00005-1

Investigating the prevalence and associated factors of elevated liver enzymes and dyslipidemia during pregnancy

Scientific Reports Ananya Dutta Mou, Nurshad Ali Feb 01, 2025 DOI: 10.1038/s41598-025-88798-4

N-terminal fragment shedding contributes to signaling of the full-length adhesion receptor ADGRL3

Journal of Biological Chemistry Nicole A. Perry-Hauser, Jonathan R. Du Rand, Kuo Hao Lee et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2025.108174

Human brain organoids identify glioma inhibitors

Nature Reviews Drug Discovery Sarah Crunkhorn Feb 01, 2025 DOI: 10.1038/d41573-025-00007-z

EXO1 is a key gene for lung-resident memory T cells and has diagnostic and predictive values for lung adenocarcinoma

Scientific Reports Zhuoqi Li, Xiaoyan Lin, Yuanhui Yang et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88126-w

Identification of ABHD6 as a lysophosphatidylserine lipase in the mammalian liver and kidneys

Journal of Biological Chemistry Arnab Chakraborty, Prajwal Punnamraju, Theja Sajeevan et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2025.108157

DNA-PKcs inhibitor causes genomic alterations

Nature Reviews Drug Discovery Sarah Crunkhorn Feb 01, 2025 DOI: 10.1038/d41573-025-00004-2

Spatiotemporal simulation of blue-green space pattern evolution and carbon storage under different SSP-RCP scenarios in Wuhan

Scientific Reports Guiyuan Li, Wangzhen Wang, Bowen Li et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88299-4

Betagenin ameliorates diabetes by inducing insulin secretion and β-cell proliferation

Journal of Biological Chemistry Tomotaka Yokoo, Kazuhisa Watanabe, Kaoruko Iida et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2025.108202

Engineered T cells traverse new terrain

Nature Reviews Drug Discovery Katie Kingwell Feb 01, 2025 DOI: 10.1038/d41573-025-00002-4

Study on the effects of fissure geometric characteristics on the mechanical behavior and failure mechanism of granite under uniaxial compression test

Scientific Reports Zhaolong Sang, Donghui Ma, Yaoyao Meng et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88278-9

Receptor-independent regulation of Gα13 by alpha-1-antitrypsin C-terminal peptides

Journal of Biological Chemistry Yonghak Park, Shigeyuki Matsumoto, Kosuke Ogata et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2024.108136

Lipid nanoparticle ferries therapeutic mRNA to the placenta

Nature Reviews Drug Discovery Alex Eccleston Feb 01, 2025 DOI: 10.1038/d41573-025-00003-3

Predicting carbon dioxide emissions using deep learning and Ninja metaheuristic optimization algorithm

Scientific Reports Anis Ben Ghorbal, Azedine Grine, Ibrahim Elbatal et al. Feb 01, 2025 DOI: 10.1038/s41598-025-86251-0