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Correction for Deng et al., The <i>Arabidopsis</i> BUB1/MAD3 family protein BMF3 requires BUB3.3 to recruit CDC20 to kinetochores in spindle assembly checkpoint signaling

Correction for Deng et al., A coadapted KNL1 and spindle assembly checkpoint axis orchestrates precise mitosis in Arabidopsis

Experimental and computational insight in molecular interactions of ternary mixtures of ethyleneglycoldiacetate+ 4-methylacetophenone + dibutylamine at T = (298.15 to 318.15) K

Cost-efficient design and optimization of robotic assembly lines using a non-dominated sorting genetic algorithm framework

A rig for in vitro testing of the lumbar spine and pelvis simulating posterior, anterior and oblique trunk muscles

Abstract Numerous research questions require in vitro testing on lumbar spine and pelvis specimens. The majority of test setups apply forces and torques via the uppermost vertebral body with the lowermost vertebral body fixed and have been validated for kinematics and intradiscal pressure. Models without simulation of muscle traction may produce valid data only for testing conditions for which they have been validated. In vitro test setups with simulation of muscle traction would appear to be useful for conditions beyond such conditions. The aim of the present study was to describe and validate a test rig for the lumbar spine that applies the forces directly to the vertebral bodies via artificial muscle attachments and thus includes the stabilising effects of the muscles known from the literature. The artificial muscle attachments were chosen to get a stable fixation of the pulleys on the cadaver. The location of force application was as close as possible to the physiological footprint of the muscle on the bone. Three paired muscles were combined by individual linear actuators and simulated under force control (posterior, anterior and oblique trunk muscles). An optical 3D motion capture system (GOM, Zeiss, Germany) was used to measure the reposition of the entire lumbar spine and the sacrum against the ilium. At the same time, the force applied to all simulated muscles was recorded. All muscle attachments could be loaded up to a maximum force of 1 kN without failure. The following reposition of the lumbar spine could be generated by the simulated muscle traction keeping the force below each muscle’s individual strength: extension 18°, flexion 27°, lateral bending 33°, axial rotation 11°. The effects on lumbar spine reposition of the individual trunk muscles differed depending on the direction of movement. The anterior trunk muscles were the most acting for flexion/extension, at 0.16 ± 0.06°/N, while the oblique trunk muscles were the most acting for lateral bending (0.17 ± 0.16°/N) and axial rotation (0.10 ± 0.14°/N). The maximum nutation of the sacroiliac joint (SIJ) was on average 1,2° ± 0,2°. The artificial muscle attachments to the vertebral bodies proved to be withstand physiologically occurring forces. The range of motion generated in the test rig was physiological. The SIJ nutation determined and the direction of action of the muscle groups correspond to literature data. The order of the individual muscle effects on lumbar spine reposition corresponds to the distance between the muscle insertions and the physiological centre of rotation. In conclusion, taking into account the limitations, the lumbar spine test rig presented here allows the analysis of movements of the lumbar spine and pelvis resulting directly from simulated muscle tractions and thus enables a test environment close to in vivo conditions.

Covered Stent Correction for Sinus Venosus Atrial Septal Defects, an Emerging Alternative to Surgical Repair: Results of an International Registry

BACKGROUND: Covered stent correction for a sinus venosus atrial septal defect (SVASD) was first performed in 2009. This innovative approach was initially viewed as experimental and was reserved for highly selected patients with unusual anatomic variants. In 2016, increasing numbers of procedures began to be performed, and in several centers, it is now offered as a standard of care option alongside surgical repair. However, covered stent correction for SVASD is not recognized by regulatory authorities, and in the minds of many pediatric and adult congenital cardiologists and surgeons, the condition is viewed as treatable only by cardiac surgery with cardiopulmonary bypass. METHODS: In April 2023, all centers identified from international conferences, publications, and colleague networks to be undertaking covered stent correction for SVASD were invited to participate in a retrospective audit of their procedures. RESULTS: Data were received on 381 patients from 54 units over a 12-year period with 90% of procedures being performed over the past 5 years. Balloon-expandable stents (8 types) were used in the majority; self-expanding stents (4 types) were used in 4.5%. The commonest stent was the 10-zig covered Cheatham Platinum stent in 62% of cases. In 10 procedures, the stent embolized requiring surgical retrieval and repair of the defect, resulting in technically successful implantation in 371 of 381 (97.4%). Major complications (surgical drainage of tamponade, pacemaker implantation, surgery for pulmonary vein occlusion, and late stent removal) occurred in 5 patients (1.3%). Repeat catheterization to correct residual leaks was required in 7 patients (1.8%). Thus, 359 of 381 patients (94.2%) had successful correction without major complications or additional catheter interventions. CONCLUSIONS: This article details the exponential uptake of covered stent correction for SVASD during the past 5 years. Cardiopulmonary bypass was avoided in the majority of patients, and major complications were infrequent. Prospective registries with standardized definitions, inclusion criteria, and follow-up and comparative studies with surgery are now required to help support the extension of covered stent correction as an alternative standard-of-care option for patients with an SVASD.

Identification of methionine metabolism related prognostic model and tumor suppressive functions of BHMT in hepatocellular carcinoma

Correction to: Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy

Development of CoAP protocol for communication in mobile robotic systems using IoT technique

A Young Man With Syncope: What Is the Diagnosis?

Utility of global longitudinal strain in early identification of chronic cardiotoxicity in asymptomatic long-term malignant lymphoma survivors with normal left ventricle ejection fraction

Abstract Malignant lymphoma survivors are at increased risk for anthracycline and/or radiotherapy-induced chronic cardiotoxicity. Proper long-term follow-up is essential for malignant lymphoma survivors after-care. This study aimed to assess TTE parameters of potential subclinical cardiotoxicity and to examine their utility in diagnosing chronic cardiotoxicity. Improvement of the diagnostic process may precede the manifestation of cardiac adverse events. Main objective of the study was to improve the identification of cancer survivors in increased risk of treatment cardiotoxicity. To achieve this goal, utility of various echocardiography parameters was examined.In this retrospective study we analysed TTE of 167 subjects with speckle tracking according to the European Society of Echocardiography guidelines during the follow-up period. 88 of them were long-term lymphoma survivors diagnosed with malignant lymphoma between the years 1994–2015. Minimum follow up period was 5 years with the median of 10 years after anti-cancer treatment cessation. TTE were performed between the years 2017–2022 at cardio-oncology outpatient office during regular follow-up period. A total of 79 volunteers with no history of chronic heart failure (CHF) or decline in LVEF, 51 (64.6%) of whom were males, with the median age of 46 (16–58) years were included in the analysis as control group. Control subjects had various indications for TTE (e.g. preoperative examination, benign palpitations, or with well controlled arterial hypertension taking two antihypertensives at most). Ischemic heart disease was ruled out by stress test. None of the control subjects had history of stroke or chronic lower limb ischemia. All control subjects were considered clinically stable with no sign of cardiac impairment caused by primary disease. Both cancer survivors and control group were divided into subgroups based on LVEF: lower normal LVEF (53–61%), and higher normal LVEF (&gt; 61%). Survivors with lower normal LVEF (53–61%) had a statistically significant decline in GLS compared to those with higher normal LVEF (&gt; 61%). This phenomenon was not observed in control group indicating a possible additional diagnostic value of this parameter. Inclusion of GLS assessment in follow-up TTE examination of subjects with lower normal LVEF may improve the sensitivity of detection of chronic cardiotoxicity. Patients with declined GLS and lower normal LVEF are candidates for intensified follow-up to precede manifestation of cardiac adverse events.

The Mysterious Masks of Hypercholesterolemia: A Unique Clinical Case

Vibration signal analysis for rolling bearings faults diagnosis based on deep-shallow features fusion

Abstract In engineering applications, the bearing faults diagnosis is essential for maintaining reliability and extending the lifespan of rotating machinery, thereby preventing unexpected industrial production downtime. Prompt fault diagnosis using vibration signals is vital to ensure seamless operation of industrial system avert catastrophic breakdowns, reduce maintenance costs, and ensure continuous productivity. As industries evolve and machines operate under diverse conditions, traditional fault detection methods often fall short. In spite of significant research in recent years, there remains a pressing need for improve existing methods of fault diagnosis. To fill this research gap, this research work aims to propose an efficient and robust system for diagnosing bearing faults, using deep and Shallow features. Through the evaluated experiments, our proposed model Multi-Block Histograms of Local Phase Quantization (MBH-LPQ) showed excellent performance in classification accuracy, and the audio-trained VGGish model showed the best performance in all tasks. Contributions of this work include: Combine the proposed Shallow descriptor, derived from a novel hand-crafted discriminative features MBH-LPQ, with deep features obtained from VGGish pre-trained of Convolutional Neural Network (CNN) using audio spectrograms, by merging at the score level using Weighted Sum (WS). This approach is designed to take advantage of the complementary strengths of both feature models, thus enhancing overall bearing fault diagnostic performance. Furthermore, experiments conducted to verify the approach’s performance is assessed based on fault classification accuracy demonstrated a significant accuracy rate on two different noisy datasets, with an accuracy rate of 98.95% and 100% being reached on the CWRU and PU datasets benchmark, respectively.

Covered Stent Treatment for Sinus Venosus Atrial Septal Defects: Early Promise and Potential Limitations

Impacts of tourism on LULC and LST dynamics in district Buner and Shangla, Pakistan

Response by Chan et al to Letters Regarding Article, “Race and Sex Differences in the Association of Bystander CPR for Cardiac Arrest”

Author Correction: A high-performance sub-THz planar antenna array for THz sensing and imaging applications

The Role of Race in Cardiovascular Disease Risk Prediction

Study on the application and evaluation method of Zen aesthetic style in furniture design under the background of sustainability

Clinical Considerations for Competitive Sports Participation for Athletes With Cardiovascular Abnormalities: A Scientific Statement From the American Heart Association and American College of Cardiology

Collaborators: Larry A. Allen, MD, MHS, FAHA, FACC; Mats Börjesson, MD, PhD, FACC; Alan C. Braverman, MD, FACC; Julie A. Brothers, MD; Silvia Castelletti, MD, MSc, FESC; Eugene H. Chung, MD, MPH, FHRS, FAHA, FACC; Timothy W. Churchill, MD, FACC; Guido Claessen, MD, PhD; Flavio D’Ascenzi, MD, PhD; Douglas Darden, MD; Peter N. Dean, MD, FACC; Neal W. Dickert, MD, PhD, FACC; Jonathan A. Drezner, MD; Katherine E. Economy, MD, MPH; Thijs M.H. Eijsvogels, PhD; Michael S. Emery, MD, MS, FACC; Susan P. Etheridge, MD, FHRS, FAHA, FACC; Sabiha Gati, BSc (Hons), MBBS, PhD, MRCP, FESC; Belinda Gray, BSc (Med), MBBS, PhD; Martin Halle, MD; Kimberly G. Harmon, MD; Jeffrey J. Hsu, MD, PhD, FAHA, FACC; Richard J. Kovacs, MD, FAHA, MACC; Sheela Krishnan, MD, FACC; Mark S. Link, MD, FHRS, FAHA, FACC; Martin Maron, MD; Silvana Molossi, MD, PhD, FACC; Antonio Pelliccia, MD; Jack C. Salerno, MD, FACC, FHRS; Ankit B. Shah, MD, MPH, FACC; Sanjay Sharma, BSc (Hons), MBChB, MRCP (UK), MD; Tamanna K. Singh, MD, FACC; Katie M. Stewart, NP, MS; Paul D. Thompson, MD, FAHA, FACC; Meagan M. Wasfy, MD, MPH, FACC; Matthias Wilhelm, MD This American Heart Association/American College of Cardiology scientific statement on clinical considerations for competitive sports participation for athletes with cardiovascular abnormalities or diseases is organized into 11 distinct sections focused on sports-specific topics or disease processes that are relevant when considering the potential risks of adverse cardiovascular events, including sudden cardiac arrest, during competitive sports participation. Task forces comprising international experts in sports cardiology and the respective topics covered were assigned to each section and prepared specific clinical considerations tables for practitioners to reference. Comprehensive literature review and an emphasis on shared decision-making were integral in the writing of all clinical considerations presented.