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Projected heatwave hazards in an eastern Amazonian metropolis under contrasting CMIP6 scenarios

NeuroSymbolicPhishDefend for adaptive multimodal phishing detection against evolving artificial intelligence driven threats

Mechanism of matrine inhibiting retinoblastoma cell growth by downregulating NR1D2 to regulate phosphorylation of the PI3K/AKT signaling pathway

Seed and soil provenance in the production and survival of Melanoxylum brauna seedlings

Automated quantification of lens epithelial cell density using deep learning: validation and large-scale clinical application

VKORC1L1–mediated vitamin K recycling counters ferroptosis to promote endothelial repair

Abstract Vitamin K is classically known for hepatic γ-carboxylation via VKORC1, yet accumulating evidence suggests broader redox-regulatory roles. Here, we characterize the VKORC1 paralogue VKORC1L1 as an anti-oxidative enzyme that couples the vitamin K cycle to ferroptosis defense in the endothelium. In human coronary artery endothelial cells (HCAEC), menaquinone-7 (Vitamin K2, MK-7) increased viability and attenuated RSL3-induced lipid peroxidation, ferroptosis, and NF-κB-dependent inflammatory activation. In vivo, a MK-7 enriched diet accelerated reendothelialization after electric carotid injury in C57BL/6J mice without altering hemostasis. Silencing VKORC1L1, but not the coagulation-linked VKORC1, diminished HCAEC proliferation, raised reactive oxygen species, and triggered NF-κB activation. Importantly, MK-7 failed to rescue these effects in VKORC1L1-deficient cells, supporting a functional requirement for VKORC1L1 in vitamin K-mediated cytoprotection. Transcriptomics of VKORC1L1-deficient cells revealed a lipid peroxide/NF-κB/TNF pathway that amplified oxidative inflammation. This signaling axis was blocked by the lipid-radical scavenger ferrostatin-1 or by inhibiting TNF shedding. Collectively, these data identify VKORC1L1 as a redox-responsive component of the endothelial vitamin K cycle that limits lipid peroxides, suppresses ferroptosis, restrains TNF-driven inflammation, and promotes vascular repair.

Domain-robust vision transformer with hierarchical swin encoding for explainable low-latency driver drowsiness detection

Perforator artery analysis and salvage procedure of propeller flaps on the reconstruciton of distal lower extremity

SecureTrust-FL: trust-aware privacy-preserving federated learning for network intrusion detection

Seasonal water quality index prediction in Guilin karst water system: an explainable machine learning approach

Spatiotemporal dynamics of population change in flood risk zones of the Pearl River Delta (1985–2024)

Repurposing trifluridine as an anti-Staphylococcus aureus agent targeting virulence factor staphyloxanthin and attachment genes

Mathematical modeling and optimization of a three-echelon supply chain management by incorporating circular consumption, cooperative advertisement cost, and selling price decisions

A pilot study of the effect of 3D-Schwann-like cells derived from human adipose-derived stem cells on surgery-induced neurogenic bladder

Hydrochemical characterization and irrigation suitability mapping of groundwater in Pashupathihal subwatershed, karnataka

Spatiotemporal information fusion for photon-level dynamic imaging

Risk of cardiovascular events and death following retinal arterial occlusion and transient monocular visual loss

Abstract Acute retinal ischaemic events, ranging from central retinal artery occlusions (CRAO) and branch retinal artery occlusions (BRAO) to transient ischaemic monocular vision loss (TMVL), cause sudden and often severe vision loss, yet their broader implications for systemic vascular health are not well defined. To investigate this, we conducted a large, propensity-matched cohort study including a total of 566 patients at an academic ophthalmic hospital in London, United Kingdom, linking ophthalmic diagnoses to national records of cardiovascular events and mortality. Our findings reveal that patients experiencing a CRAO have a nearly threefold increased risk of a subsequent ischaemic stroke or myocardial infarction, when compared to matched controls. This elevated risk, however, was not apparent in individuals who suffered a BRAO or TMVL, suggesting a distinct risk profile for CRAO. Systemic comorbidities like hypertension and diabetes were prevalent in all groups. Atrial fibrillation was newly diagnosed in 6% of patients with CRAO within one year. Patients with BRAO were more likely to undergo carotid endarterectomy than those with CRAO. The substantial risk of serious cardiovascular morbidity following retinal arterial ischaemia highlights the need to ensure such patients benefit from early treatment and prolonged cardiac monitoring and rigorous implementation of secondary prevention in RAO and suspected embolic TMVL.

Predictability of sleep slow oscillation emergence and spatial extent from pre-onset neural dynamics

Based on artificial intelligence-assisted generation and in-depth in-silico evaluation of potential inhibitors targeting Stearoyl-CoA desaturase 1 (SCD-1)

Attention-enhanced deep temporal fusion network for cloud-IIoT prognostics of EV induction motors under dynamic loads