Browse Articles

Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning

Experimental evaluation of DC-DC buck converter based on adaptive fuzzy fast terminal synergetic controller

Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity

Early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological features

Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology

Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis

Maternal asthma imprints fetal lung ILC2s via glucocorticoid signaling leading to worsened allergic airway inflammation in murine adult offspring

Abstract The root of asthma can be linked to early life, with prenatal environments influencing risk. We investigate the effects of maternal asthma on the offspring’s lungs during fetal and adult life. Adult offspring of asthmatic mothers show an increase in lung group 2 innate lymphoid cell (ILC2) number and function with allergen-induced lung inflammation. Offspring of asthmatic mothers show phenotypic alteration of their lung ILC2s during fetal life, with increased expression of genes related to activation and glucocorticoid signaling. Furthermore, these offspring carry overlapping chromatin-accessible altered regions, including glucocorticoid receptor-binding regions in their lung ILC2s both at the fetal stage and adulthood, suggesting persistent prenatal epigenetic changes. Moreover, maternal exposure to glucocorticoids has similar effects on fetal lung ILC2s and contributes to allergen-induced lung inflammation during adulthood. Thus, asthma during pregnancy may have long-term effects on lung ILC2s in the offspring from the embryonic period, contributing to an increased risk of developing asthma.

Robust collection and processing for label-free single voxel proteomics

Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

Revealing an unexpectedly low electron injection threshold via reinforced shock acceleration

Author Correction: Future increase in compound soil drought-heat extremes exacerbated by vegetation greening

Efficient continuous SF6/N2 separation using low-cost and robust metal-organic frameworks composites

Genome-wide association study unravels mechanisms of brain glymphatic activity

Emergent patterns of reef fish diversity correlate with coral assemblage shifts along the Great Barrier Reef

Abstract Escalating climate and anthropogenic disturbances draw into question how stable large-scale patterns in biological diversity are in the Anthropocene. Here, we analyse how patterns of reef fish diversity have changed from 1995 to 2022 by examining local diversity and species dissimilarity along a large latitudinal gradient of the Great Barrier Reef and to what extent this correlates with changes in coral cover and coral composition. We find that reef fish species richness followed the expected latitudinal diversity pattern (i.e., greater species richness toward lower latitudes), yet has undergone significant change across space and time. We find declines in species richness at lower latitudes in recent periods but high variability at higher latitudes. Reef fish turnover continuously increased over time at all latitudes and did not show evidence of a return. Altered diversity patterns are characterised by heterogeneous changes in reef fish trophic groups across the latitudinal gradient. Shifts in coral composition correlate more strongly with reef fish diversity changes than fluctuations in coral cover. Our findings provide insight into the extent to which classic macroecological patterns are maintained in the Anthropocene, ultimately questioning whether these patterns are decoupling from their original underlying drivers.

Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemia

Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13

Conformational diversity in class C GPCR positive allosteric modulation

CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemia

Author Correction: Snapshotting quantum dynamics at multiple time points

A roadmap from the bond strength to the grain-boundary energies and macro strength of metals

Abstract Correlating the bond strength with the macro strength of metals is crucial for understanding mechanical properties and designing multi-principal-element alloys (MPEAs). Motivated by the role of grain boundaries in the strength of metals, we introduce a predictive model to determine the grain-boundary energies and strength of metals from the cohesive energy and atomic radius. This scheme originates from the d-band characteristics and broken-bond spirit of tight-binding models, and demonstrates that the repulsive/attractive effects play different roles in the variation of bond strength for different metals. Importantly, our framework not only applies to both pure metals and MPEAs, but also unravels the distinction of the bond strength caused by elemental compositions, lattice structures, high-entropy, and amorphous effects. These findings build a physical picture across bond strength, grain-boundary energies and strength of metals by using easily accessible material properties and provide a robust method for the design of high-strength alloys.