Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

Mingjiong Zhang; Jiahua Cui; Haoyan Chen; Yifan Cheng; Qiaoyu Chen; Feng Zong; Xiao Lu; Lang Qin; Yu Han; Xingwang Kuai; Yuxing Zhang; Minjie Chu; Shuangshuang Wu; Jianqing Wu

doi:10.1038/s41467-025-56002-w

Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

M Mingjiong Zhang J Jiahua Cui H Haoyan Chen Y Yifan Cheng Q Qiaoyu Chen F Feng Zong X Xiao Lu L Lang Qin (School of Chinese as a Second Language, Peking University) Y Yu Han X Xingwang Kuai Y Yuxing Zhang (State Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry) M Minjie Chu S Shuangshuang Wu (Zhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital, Zhejiang Chinese Medical University) J Jianqing Wu (Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control, National Engineering Laboratory for VOCs Pollution Control Technology and Equipment, School of Environment and Energy)

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published January 13, 2025

DOI 10.1038/s41467-025-56002-w

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (14)

M

Mingjiong Zhang

J

Jiahua Cui

H

Haoyan Chen

Y

Yifan Cheng

Q

Qiaoyu Chen

F

Feng Zong

X

Xiao Lu

L

Lang Qin

School of Chinese as a Second Language, Peking University

Y

Yu Han

X

Xingwang Kuai

Y

Yuxing Zhang

State Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry

M

Minjie Chu

S

Shuangshuang Wu

Zhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences, The First Affiliated Hospital, Zhejiang Chinese Medical University

J

Jianqing Wu

Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control, National Engineering Laboratory for VOCs Pollution Control Technology and Equipment, School of Environment and Energy

Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

Article Details

Journal Info

Authors (14)

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