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Identification of critical endoplasmic reticulum stress-related genes in advanced atherosclerotic plaque

Exploring the role of volume energy density in altering microstructure and corrosion behavior of nitinol alloys produced by laser powder bed fusion

Study on influencing factors and prevention measures of coal-rock-gas compound dynamic disaster in deep coal mine mining

Artificial intelligence as a transforming factor in motility disorders–automatic detection of motility patterns in high-resolution anorectal manometry

Human neural rosettes secrete bioactive extracellular vesicles enriched in neuronal and glial cellular components

Validation of mixed reality in planning orbital reconstruction with patient-specific implants

Abstract This study aims to evaluate and compare the usability and performance of mixed reality (MR) technology versus conventional methods for preoperative planning of patient-specific reconstruction plates for orbital fractures. A crossover study design was used to compare MR technology with conventional three-dimensional (3D) printing approaches in the planning of maxillofacial traumatology treatments. The primary focus was on user-friendliness and the accuracy of patient-specific reconstruction planning. Secondary outcomes included investigating time differences between the two approaches and evaluating the potential effects on the learning curve. Participants were asked to complete questionnaires assessing various aspects, such as visualization, interaction, segmentation, treatment planning, and evaluation. Objective endpoints were evaluated blindly, while subjective endpoints were analyzed through a double-blind process. The total workflow time for MR technology was significantly shorter compared to the conventional method. Moreover, treatment planning using MR was significantly more accurate (p = .028), with participants reporting a higher mean global satisfaction score compared to the conventional group (80.6% vs. 72.5%). This study sheds light on the potential benefits of employing MR technology in maxillofacial orbital reconstruction. This preoperative method allows for faster and more precise design of patient-specific implants for orbital reconstruction, potentially leading to improved long-term cost-effectiveness.

Study on the crack propagation morphology and initiation law of coal rock under the action of underwater electric pulse

Biomechanical analysis of a short femoral stem used in revision total hip replacement of a standard femoral stem

A between-subjects investigation of whether distraction is the main mechanism behind music-induced analgesia

SDES-YOLO: A high-precision and lightweight model for fall detection in complex environments

A theoretical investigation of spectroscopy properties and transition properties of TlBr+ cation

Genetic proxies for clinical traits are associated with increased risk of severe COVID-19

Abstract Routine use of genetic data in healthcare is much-discussed, yet little is known about its performance in epidemiological models including traditional risk factors. Using severe COVID-19 as an exemplar, we explore the integration of polygenic risk scores (PRS) into disease models alongside sociodemographic and clinical variables. PRS were optimized for 23 clinical variables and related traits previously-associated with severe COVID-19 in up to 450,449 UK Biobank participants, and tested in 9,560 individuals diagnosed in the pre-vaccination era. Associations were further adjusted for (i) sociodemographic and (ii) clinical variables. Pathway analyses of PRS were performed to improve biological understanding of disease. In univariate analyses, 17 PRS were associated with increased risk of severe COVID-19 and, of these, four remained associated with COVID-19 outcomes following adjustment for sociodemographic/clinical variables: hypertension PRS (OR = 1.1, 95%CI 1.03–1.18), atrial fibrillation PRS (OR = 1.12, 95%CI 1.03–1.22), peripheral vascular disease PRS (OR = 0.9, 95%CI 0.82–0.99), and Alzheimer’s disease PRS (OR = 1.14, 95%CI 1.05–1.25). Pathway analyses revealed enrichment of genetic variants in pathways for cardiac muscle contraction (genes N  = 5; beta[SE]  = 3.48[0.60]; adjusted -P  = 1.86 × 10 −5 ). These findings underscore the potential for integrating genetic data into epidemiological models and highlight the advantages of utilizing multiple trait PRS rather than a single PRS for a specific outcome of interest.

A mediating role of visceral adipose tissue on the association of health behaviours and metabolic inflammation in menopause: a population-based cross-sectional study

Recycling of endocytic BDNF through extracellular vesicles in astrocytes

Deep brain stimulation of the anterior cingulate cortex reduces opioid addiction in preclinical studies

Retraction Note: An intelligent dynamic cyber physical system threat detection system for ensuring secured communication in 6G autonomous vehicle networks

Screening of Aβ and phosphorylated tau status in the cerebrospinal fluid through machine learning analysis of portable electroencephalography data

Spaciotemporal distribution characteristics of glacial lakes and the factors influencing the Southeast Tibetan Plateau from 1993 to 2023

Clinical characteristics and laparoscopic management experience of primary ovarian leiomyoma

Streptococcus pyogenes carriage rate, associated factors and antimicrobial susceptibility profiles among urban and rural schoolchildren at Gondar city, Northwest Ethiopia