Browse Articles

Integrative analysis of single-cell and transcriptome sequencing with experimental validation reveals PKHD1L1 as a novel biomarker in lung adenocarcinoma

S100A8-CAMKK2-AMPK axis confers the protective effects of mild hypothermia against cerebral ischemia-reperfusion injury in rats

Fitness costs of Mycobacterium tuberculosis resistant to rifampicin is compensated by rapid Th2 polarization mediated by early and high IL-4 production during mice infection

Clinical novel exploration of intractable fever in stroke rehabilitation: a single-center cross-sectional retrospective study

Effect of different clay additions to concrete on its ultrasonic acoustic parameters and compressive strength

Integrated gene expression and alternative splicing analysis in human and mouse models of Rett syndrome

One carbon metabolism supplementation in maturation medium but not embryo culture medium improves the yield of blastocysts from bovine oocytes

Medical image segmentation based on frequency domain decomposition SVD linear attention

Exploring influencing factors of healthy lifestyles in rural area among older adults with diabetes based on socioecological model

The technological advancement environmental regulations and their impact on energy efficiency and CO2 emissions

A novel multiple directional shearing interferometry system with synchronous polarization phase shifting

Observation of magnetic skyrmion lattice in Cr0.82Mn0.18Ge by small-angle neutron scattering

Abstract Incommensurate magnetic phases in chiral cubic crystals are an established source of topological spin textures such as skyrmion and hedgehog lattices, with potential applications in spintronics and information storage. We report a comprehensive small-angle neutron scattering (SANS) study on the B20-type chiral magnet Cr $$_{0.82}$$ Mn $$_{0.18}$$ Ge, exploring its magnetic phase diagram and confirming the stabilization of a skyrmion lattice under low magnetic fields. Our results reveal a helical ground state with a decreasing pitch from 40 to 35 nm upon cooling, and a skyrmion phase stable in applied magnetic fields of 10–30 mT, and over an unusually wide temperature range for chiral magnets of 6 K ( $$\sim T_\text {C}/2< T < T_\text {C}$$ , $$T_\text {C}=13$$ K). The skyrmion lattice forms a standard two-dimensional hexagonal coordination that can be trained into a single domain, distinguishing it from the three-dimensional hedgehog lattice observed in MnGe-based systems. Additionally, we demonstrate the persistence of a metastable SkL at 2 K, even at zero field. These findings advance our understanding of magnetic textures in Cr-based B20 compounds, highlighting Cr0.82Mn0.18Ge as a promising material for further exploration in topological magnetism.

CT-based skeletal muscle loss predicts long term prognosis in patients with distal cholangiocarcinoma undergone pancreaticoduodenectomy

Spectroscopic investigation of two xanthane dyes and design of a FRET based pesticide sensor

Perioperative treatment with cilostazol reverses steatosis and improves liver regeneration after major hepatectomy in a steatotic rat model

Abstract Cilostazol has previously been shown to reduce liver steatosis and enhance hepatic perfusion. We investigated the effects of cilostazol after major hepatectomy in a steatotic rat model. Six weeks prior to surgery, Sprague–Dawley rats were fed with a high-fructose diet. The treatment group received daily 5 mg/kg cilostazol. Seven days following the cilostazol treatment, all animals underwent 70% liver resection (PHX). Analysis of hepatic blood flow and microcirculation and immunohistochemical examinations were conducted 30 min after PHX (postoperative day [POD] 0) as well as on POD 1, POD 3 and POD 7. The weight of cilostazol-treated animals was significantly reduced compared to untreated controls after completion of the 6-week high-FRC diet. Furthermore, 41% macrovesicular steatosis was found in the control group compared to 8% in the cilostazol group. Hepatic arterial and portal venous perfusion were increased in the cilostazol group on POD 7. Lower liver enzyme release was found postoperatively in cilostazol-treated animals. Moreover, apoptosis and neutrophil infiltration were reduced after cilostazol treatment. Proliferation of hepatocytes and liver regeneration after PHX were significantly increased in the cilostazol group. Consequently, cilostazol should be evaluated as a novel strategy to reduce the rate of liver failure after PHX in steatotic liver.

Vehicle speed measurement method using monocular cameras

Abstract This paper proposes a method for fast and accurate vehicle speed measurement based on a monocular camera. Firstly, by establishing a new camera imaging model, the calibration method for variable focal lengths is optimized, simplifying the transformation process between the four coordinate systems in traditional camera imaging models, and the method does not need to restore the pixel coordinates to dedistortion. Secondly, based on the camera imaging model, a two-dimensional positioning algorithm is proposed. By leveraging the characteristics of the speed measurement problem, the complex three-dimensional positioning problem is simplified into a two-dimensional model, reducing the overall computational complexity of the positioning problem. Finally, the algorithm is combined with You Only Look Once version 7 (YOLOv7) and Deep Simple Online and Realtime Tracking (DeepSORT) algorithms, integrating multiple model structures to optimize the network, achieving precise multi-target speed measurement. Experiments show that under frame-by-frame measurement conditions, the minimum and average accuracies of this method reach 95.1% and 97.6%, respectively. Compared with other methods, it has significant advantages in speed measurement accuracy and computational efficiency. Therefore, this research outcome is expected to play an important role in intelligent transportation systems and road safety management.

Evaluation of ecological geological environment carrying capacity and analysis of driving mechanisms based on normal cloud model and geodetector model

The link between tinnitus and menstrual cycle disorders in premenopausal women

Identification of prognostic biomarkers of sepsis and construction of ceRNA regulatory networks

Identifying key genes in cancer networks using persistent homology

Abstract Identifying driver genes is crucial for understanding oncogenesis and developing targeted cancer therapies. Driver discovery methods using protein or pathway networks rely on traditional network science measures, focusing on nodes, edges, or community metrics. These methods can overlook the high-dimensional interactions that cancer genes have within cancer networks. This study presents a novel method using Persistent Homology to analyze the role of driver genes in higher-order structures within Cancer Consensus Networks derived from main cellular pathways. We integrate mutation data from six cancer types and three biological functions: DNA Repair, Chromatin Organization, and Programmed Cell Death. We systematically evaluated the impact of gene removal on topological voids ( $$\beta _2$$ structures) within the Cancer Consensus Networks. Our results reveal that only known driver genes and cancer-associated genes influence these structures, while passenger genes do not. Although centrality measures alone proved insufficient to fully characterize impact genes, combining higher-order topological analysis with traditional network metrics can improve the precision of distinguishing between drivers and passengers. This work shows that cancer genes play an important role in higher-order structures, going beyond pairwise measures, and provides an approach to distinguish drivers and cancer-associated genes from passenger genes.