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Amine functionalized magnetic resorcinol formaldehyde as a green and reusable nanocatalyst for the Knoevenagel condensation
Multiplex-PCR technique to predict polymorphic antigens – M, N, S and s – and associations between their alleles and Mia-associated hybrid glycophorins
An in silico analysis of heart rate impact on wall shear stress hemodynamic parameters in aortic coarctation
Abstract This study examines how heart rate (HR) affects hemodynamics in a South African infant with Coarctation of the Aorta. Computed tomography angiography segments aortic coarctation anatomy; Doppler echocardiography derives inlet flow waveforms. Simulations occur at 100, 120, and 160 beats per minute, representing reduced, resting, and elevated HR levels. Turbulence was analyzed over time and space using turbulence-resolving and pulsatile large-eddy simulations. Specifically, a 60% reduction in HR led to a reduction in maximum velocity by 45%, and a 57% decrease in pressure drop. The reduction in turbulence-related metrics was less significant. The ratio of turbulent kinetic energy to total kinetic energy decreased by 2%, while turbulent wall shear stress decreased by 3%. These results demonstrate that HR significantly affects velocity and pressure drop, while turbulence arising from the coarctation region is relatively unaffected. The balance between turbulent kinetic energy and total kinetic energy shows minimal enhancement due to the complex interplay among HR, turbulence, and geometry. This complexity prompts discussion on how HR-slowing medications, such as beta-blockers or ivabradine, could positively influence hemodynamic stresses. In particular, the results indicate that while HR modulation can influence flow dynamics, it may not significantly reduce turbulence-induced shear stresses within the coarctation zone. Therefore, further investigation is necessary to understand the potential impact of HR modulation in the management of CoA, and whether interventions targeting the anatomical correction of the coarctation may be more effective in improving hemodynamic outcomes.
Design of an efficient magnetic brush solid acid and its catalytic use in organic reactions
Effects of key physiological parameters on cardiovascular disease and osteoporosis risk in perimenopausal and postmenopausal women
Diagnostic impact of DNA methylation classification in adult and pediatric CNS tumors
MD-Unet for tobacco leaf disease spot segmentation based on multi-scale residual dilated convolutions
Author Correction: Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort study
A quasi-opposition learning and chaos local search based on walrus optimization for global optimization problems
Sex-specific effects of prenatal bisphenol A exposure on transcriptome-interactome profiles of autism candidate genes in neural stem cells from offspring hippocampus
Evaluating the efficiency of 16S-ITS-23S operon sequencing for species level resolution in microbial communities
Anthropometric but not motor characteristics of young volleyball players were improved after a one-week-long intense training sports camp
Characterization and genome analysis of a novel phage BP15 infecting Vibrio parahaemolyticus
Multiscale regional calibration network for crowd counting
Molecular diversity and genetic potential of new maize inbred lines across varying sowing conditions in arid environment
A method for monitoring three dimensional surface deformation in mining areas combining SBAS-InSAR, GNSS and probability integral method
Predicting changes in agricultural yields under climate change scenarios and their implications for global food security
Investigating the intrinsic top-down dynamics of deep generative models
Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs
Abstract Non-invasive physical plasma (NIPP) has been used effectively for wound healing in human medicine for over two decades. The advantages are that NIPP has few side effects, is painless and gentle on the tissue. The therapeutic effect is mediated by reactive oxygen species (ROS). Based on the biomedical effects known to date, it can be assumed that NIPP can also be used for wound treatment in non-human mammals. In this prospective, non-randomized monocentric clinical trial, 43 European hedgehogs with cut and bite wounds were treated with conventional wound management (CWM: 21 patients) and compared with 22 patients with CWM plus NIPP treatment (CWM + NIPP). Under NIPP treatment, patients showed no signs of pain, stress or discomfort, even after several applications. In 76% of CWM + NIPP patients, three or four NIPP applications were sufficient. In patients in the CWM + NIPP group, wound treatment was completed statistically significantly 6 d earlier (CWM: 19.0 d versus CWM + NIPP: 13.2 d; p = 0.0008). This wildlife clinical trial demonstrates that NIPP can be used to improve wound healing in wild European hedgehogs. It is conceivable that NIPP therapy could also lead to positive effects in other injured wild animals, domestic animals or livestock.