Browse Articles

The Role of Torsion on the Force-Coupled Reactivity of a Fluorenyl Naphthopyran Mechanophore

Revealing the Potential-Dependent Rate-Determining Step of Oxygen Reduction Reaction on Single-Atom Catalysts

ROMP of Macromonomers Prepared by ROMP: Expanding Access to Complex, Functional Bottlebrush Polymers

Solid-State Nuclear Magnetic Resonance Spectroscopy for Surface Characterization of Metal Oxide Nanoparticles: State of the Art and Perspectives

Germanium Atoms Exceed the Tetrahedral Coordination in MFI Zeolite

Organocatalytic Asymmetric Synthesis of <i>o</i>-Carboranyl Amines

<i>s-d</i> Coupling-Induced Dynamic Off-Centering of Cu Drives High Thermoelectric Performance in TlCuS

Solvent-Dependent Reactivity of Fe(CO)₅ under Superacidic and Oxidative Conditions

How flight helped bats become invincible to viruses

Rational Design of Prussian Blue Analogues for Ultralong and Wide-Temperature-Range Sodium-Ion Batteries

Context-Dependent Heterotypic Assemblies of Intrinsically Disordered Peptides

Ni-Catalyzed Enantioselective Desymmetrization: Development of Divergent Acyl and Decarbonylative Cross-Coupling Reactions

Can Low Structural Anisotropy Produce High Optical Anisotropy? Anomalous Giant Optical Birefringent Effect in PI₄AlI₄ in Focus

Asteroid Bennu contains building blocks of life

Diversity of human gut microbes in Africa reflects geography, lifestyle and health status

Asteroid fragments upend theory of how life on Earth bloomed

Identifying the Bifunctional Mechanism in Alkaline Water Electrolysis by Lewis Pairs at the Single-Atom Scale

Photocatalytic Methanol Dehydrogenation with Switchable Selectivity

Underground bacteria serve alcohol to methane-making microbes

The effect of physical exercise and cognition-orientated interventions on post-stroke cognitive function: Protocol for an overview of reviews

Background Strokes are becoming more common, and with improving survival rates, the prevalence of stroke survivors has increased. Almost half of chronic stroke survivors are cognitively impaired, and healthcare services are struggling to manage these patients, leaving some feeling “abandoned”. Several systematic reviews have investigated the effect of physical exercise and cognition-orientated interventions on post-stroke cognitive impairment, and have produced conflicting findings, making it difficult for clinicians and guideline producers to make evidence-based decisions. This overview of reviews aims to provide a comprehensive overview of systematic reviews investigating the effect of physical exercise and cognition-orientated interventions on post-stroke cognitive function, assess methodological quality and certainty of evidence, and identify sources of discordance between these reviews. Methods Eight databases–Embase, Medline, CINAHL, Psycinfo, SPORTDiscus, The Cochrane Database of Systematic reviews, Epistemonikos, and Scopus–plus grey literature sources will be searched. The eligibility criteria include systematic reviews of trials that included an adult stroke population and investigated physical exercise and/or cognition-orientated interventions. Only reviews that assessed at least one of the DSM-5 neurocognitive domains will be included. Screening, data extraction, and quality appraisal will be conducted by two independent reviewers. Methodological quality, certainty of evidence, and primary study overlap will be assessed using the AMSTAR-2, GRADE, and GROOVE tools, respectively. Interventions will be grouped into exercise, cognition-orientated, and combined interventions, and findings will be synthesised narratively. Heterogeneity assessment will be conducted to identify factors causing discordance between reviews. Discussion The findings of this overview will allow decision makers to make evidence-based decisions, stratified by methodological quality and certainty of evidence. Heterogeneity assessment may identify factors causing discordance between systematic reviews, which could inform the design of future studies. Trial registration Registration: PROSPERO CRD42024534179.