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Risk factors and prediction model of metabolic disorders in adult patients with pituitary stalk interruption syndrome
De-ashed-biochar slow-release N fertilizer increased NUE in alkaline calcareous soils under wheat and maize crops
Abstract Recently biochar has widely been reported as carrier of SRFs. However, the performance of SRFs synthesized from pristine biochar is still low and could not achieve the significant benefits compared to conventional N fertilizers. To overcome this limitation and research gap, BSRFs were synthesized using modified / de-ashed biochar as N-carrier. We hypothesized that BSRFs would NUE especially in alkaline calcareous soils for whom there is no specific SRF exist previously. In this study, the efficacy of BSRF formulated with 1:1 mass ratio of de-ashed biochar and urea was compared with CU and CSRF for improving NUE under wheat (Triticum aestivum L.) and maize (Zea mays L.) cropping system in two different textured soils. The results showed that compared to CU and CSRF, the addition of BSRF significantly increased the retention of soil mineral-N (NH4 +-N, NO3 −-N) which, consequently, enhanced the crops’ N-uptake up to 23.71% in wheat and 26.55% in maize. It was further observed that SOC contents were increased up to 50.79% in wheat and up to 47.61% in maize at harvest. The addition of BSRF enhanced the CEC up to 32.95% under wheat and up to 27.73% under maize, compared to CU. Eventually, BSRF significantly increased the grain yield and NUE of wheat by 12.04% and 40.44%, while the maize grain yield and NUE increased by 21.06% and 45.56%, respectively. This study concludes that BSRFs had a stronger yield-increasing effect than CU alone attributing to enhanced N retention and crop uptake in alkaline calcareous soils. It was also found that the de-ashed biochar is a strong candidate to formulate new SRFs with improved performance.
Transcriptome and metabolite conjoint analysis reveals the seed dormancy release process of perilla
SH-SSQ as a modifier for superior mechanical properties and improved plasticity of 3D printed PLA
Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumors
Short-term diet intervention comprising of olive oil, vitamin D, and omega-3 fatty acids alters the small non-coding RNA (sncRNA) landscape of human sperm
3D printed miniature attenuated total internal reflection assisted fluorescence microscopy
An effective MRI perfusion threshold based workflow to triage additional 18F-FET PET in posttreatment high grade glioma
MiRNA expression profiling and clinical implications in prostate cancer across various stages
Abstract This study aims to screen and identify microRNA (miRNA) expression profiles across different stages of prostate cancer (PCa) and benign prostatic hyperplasia (BPH) using high-throughput sequencing. The study seeks to determine whether specific miRNAs show consistent differential expression across various stages of PCa, with the goal of identifying potential biomarkers relevant to disease progression. In this study, a total of 12 specimens of PCa and BPH were collected from September 2021 to June 2022 in the Second Affiliated Hospital of Nanchang University, 330,006, P.R. China (including 3 specimens of early localized tumor, local invasion, and distant metastasis tumor and 3 specimens of BPH). The expression profile of miRNA was screened by high-throughput sequencing technology, and the differentially expressed miRNA between each group was screened by relevant bioinformatics analysis. Further targeted miRNA site analysis GO enrichment analysis and KEGG enrichment analysis of miRNA-derived genes were performed on the above differentially expressed miRNAs. Finally, the expression of hsa-miR-6715b-3p in PCa tissues was verified using qRT-PCR assay. A total of 1526 miRNAs were identified through high-throughput sequencing. By comparing groups, 228 differentially expressed miRNAs were identified, with 100 upregulated and 128 downregulated. Additionally, 69 novel miRNAs were predicted. qRT-PCR results showed that hsa-miR-6715b-3p was highly expressed in PCa tissues compared to BPH tissues. This study presents a preliminary investigation of the miRNA expression profiles in PCa and identifies hsa-miR-6715b-3p as a promising biomarker for disease progression. Our findings validate the high expression of hsa-miR-6715b-3p in PCa tissues and highlight its potential role in critical oncogenic pathways. These results provide a theoretical foundation for further functional studies to explore its clinical utility and its role in therapy resistance and disease progression, contributing to the growing knowledge of miRNA-based biomarkers in PCa.
Research on the relationship between perceived social support and positive coping style of fire rescue personnel with the mediating effects of positive emotions and meaning in life
Calcium levels modulate platelet function, platelet-cancer cell interaction, and cancer cell invasion
Treg derived Amphiregulin protects from murine lupus nephritis via tissue reparative effects
Abstract Systemic lupus erythematosus (SLE) is a common autoimmune disease that affects multiple organ systems. Among the most severe manifestations of SLE is lupus nephritis (LN), which causes particularly high morbidity. Recently, we identified amphiregulin (AREG), an epidermal growth factor receptor ligand, as a key mediator of LN via downregulation of pathogenic CD4 + T-cell responses. In human LN, AREG is mainly produced by regulatory T cells (Tregs) and monocytes/macrophages (M/M). Since AREG´s functions have been shown to vary considerably depending on the source, we aimed to clarify the cell-type-specific roles of AREG using the pristane model of LN. Conditional knockout mice lacking Treg- but not M/M-derived AREG showed worse LN outcome at 12 and 15 months with increased glomerular cell proliferation, apoptosis and renal tissue fibrosis. Interestingly, immune responses were not relevantly affected by the lack of AREG from either leukocyte source, indicating a different mechanism. In this respect, in vitro studies demonstrated improved wound healing of murine mesangium and tubulus cells and enhanced regeneration and sprouting of human glomerular endothelial cells after incubation with recombinant AREG. These findings underscore the importance of Treg-derived AREG in tissue regeneration and protection from fibrosis in LN, highlighting AREG as a potential therapeutic target.
A multi objective optimization framework for smart parking using digital twin pareto front MDP and PSO for smart cities
Abstract Smart cities are designed to improve the quality of life by efficiently using resources and smart parking is an important part of this puzzle to help alleviate traffic congestion and efficiently address energy consumption and search time for parking spaces. However, existing parking management systems have issues with resource management, system scalability, and real-time dynamic changes. In response to these challenges, this paper proposes a Multi-Objective Optimization Framework for Smart Parking incorporating Digital Twin Technology, Pareto Front Optimization, Markov Decision Process (MDP), and Particle Swarm Optimization (PSO). Hence, the proposed framework utilizes Digital Twin whereby there is a generation of a virtual model of the existing parking infrastructure that can give a real-time prospective estimation of the entire system. The Pareto Front is then used for multi-objective optimization of the search domain, where the goal is to minimize the search time, use of energy, and traffic disruption, and maximize the availability of parking spaces. The MDP splits the resource allocation problem into a value function which can then model the real-time parking requests. Further, PSO refines the solutions found from the Pareto front for a globally superior distribution. The framework is evaluated using extensive simulations across multiple metrics: search time, energy, congestion level, scalability, and utilization. Evaluation outcomes also show that the proposed algorithm is better than Round Robin, Random Allocation, and Threshold Based algorithms in terms of 25% improvement in the search time, 18% better energy usage, and 30% less traffic congestion. This work has shown the prospects of combining hybrid optimization and real-time decision-making in the enhancement of parking management in smart cities for better efficiency in urban mobility.
Neighboring and polarization effects on line shape of the modulation transfer spectroscopy in lower ground hyperfine state of Rb atoms
New insights of cerium oxide nanoparticles in head and neck cancer treatment
Novel method for predicting the cracks of oxide scales during high temperature oxidation of metals and alloys by using machine learning
Optimal energy management for multi-energy microgrids using hybrid solutions to address renewable energy source uncertainty
Reducing soft tissue artefacts through projection of markers and microwave imaging: An exploratory study
Abstract Soft tissue artefacts (STA) are widely considered the most critical source of error in skin-mounted marker-based biomechanics, negatively impacting the clinical usability of skin-mounted marker-based data. Amongst the numerous solutions proposed to ameliorate STA, incorporating true bone movement—acquired using adaptive constraints, projection of markers, or various imaging modalities—has been reported to improve kinematic accuracy. However, efficacy of these proposed solutions reduces for different investigated motions and participants. In this study, we propose two novel marker projection schemes, wherein a cluster of markers are projected onto the bone surface during motion. Additionally, we investigate the feasibility of applying a novel, safe and cost-effective imaging modality—microwave imaging—to detect the location of the bone from the skin surface. Our results indicate that the novel marker projection schemes reduce kinematic errors significantly (by 50%) and improve the quality of computed kinematics (95% correlation to true bone movement). In addition, our results show that microwave imaging was able to detect the bone from the skin surface in both male and female anatomical models of varying body mass index scores and poses. We believe our findings underscore the generalisability and applicability of our proposed solution to reduce STA.