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A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis
The YoaA-χ helicase modulates the dynamics of single-stranded DNA binding protein on DNA
The mediating role of technology anxiety in the impact of loneliness on technology behavioral intention among community-dwelling older adults
In this modern digital era, older adults encounter considerable challenges in technology adoption, primarily due to varying degrees of technology anxiety and its implications on their behavioral intentions. We conducted a cross-sectional survey with 250 participants aged 60 and older in Taiwan to investigate the mediating role of technology anxiety in the dynamic between loneliness and technology usage intentions. The results reveal that participants exhibited mild levels of loneliness (mean score: 1.53), moderate technology anxiety (mean score: 19.29), and moderate to high intentions toward technology use (mean score: 10.96). The study identifies a significant total effect of loneliness on technology behavioral intention (c = -0.508, p < 0.001). Specifically, loneliness was found to significantly influence technology anxiety (a = 1.158, p < 0.001), which in turn significantly impacted behavioral intention, even after adjusting for loneliness (b = -0.161, p < 0.001). Technology anxiety partially mediated the relationship between loneliness and behavioral intention, exacerbating its negative impact (c’ = -0.322, p < 0.001). These findings highlight the critical need for targeted interventions and policy measures to address and mitigate the barriers to technology adoption faced by older adults.
Amyloid-β-induced alteration of fast and localized calcium elevations in cultured astrocytes
Insulin-Derived Amyloidosis
AI linked to explosion of low-quality biomedical research papers
Cell cycle duration determines oncogenic transformation capacity
High resolution clonal architecture of hypomutated Wilms tumours
Abstract A paradigm of childhood cancers is that they have a low mutation burden, with some ostensibly bearing fewer mutations than the normal tissues from which they derive. We set out to resolve this paradox by examining paediatric renal cancers with exceptionally few mutations using high resolution, high depth sequencing approaches. We find that apparent hypomutation is the result of unusual clonal architecture due to a normal tissue-like mode of tumour evolution, raising the possibility that the mutation burden of some cancers has been systematically misjudged.
Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study
Vibration offers a potential alternative modality for transcutaneous auricular vagus nerve stimulation (taVNS). However, mechanisms of action are not well-defined. The goal of this pilot study was to evaluate the potential of vibrotactile stimulation of the outer ear as a method for activating central brain regions similarly to established vagal nerve stimulation methods. Seven patients with intractable epilepsy undergoing stereotactic electroencephalography (sEEG) monitoring participated in the study. Vibrotactile taVNS was administered across five vibration frequencies (2, 6, 12, 20, and 40 Hz) following a randomized stimulation pattern with 30 trials per frequency. Spectral coherence during stimulation was analyzed across theta (4–8 Hz), alpha (8–13 Hz), beta (13–30 Hz), and broadband gamma (70–170 Hz) frequency bands. At the group level, vibrotactile taVNS significantly increased coherence in theta (effect sizes 6 Hz: r = 0.311; 20 Hz: r = 0.316; 40 Hz: r = 0.264) and alpha bands (effect sizes 20 Hz: r = 0.455; 40 Hz: r = 0.402). Anatomically, multiple limbic brain regions exhibited increased coherence during taVNS compared to baseline. The percentage of total electrode pairs demonstrating increased coherence was also quantified at the individual level. Twenty Hz vibration resulted in the highest percentage of responder pairs across low-frequency coherence measures, with a group-average of 33% of electrode pairs responding, though inter-subject variability was present. Overall, vibrotactile taVNS induced significant low-frequency coherence increases involving several limbic system structures. Further, parametric characterization revealed the presence of inter-subject variability in terms of identifying the vibration frequency with the greatest coherence response. These findings encourage continued research into vibrotactile stimulation as an alternative modality for noninvasive vagus nerve stimulation.
Serum proteomic approach to identifying differentially expressed proteins in effusive feline infectious peritonitis
Upadacitinib — An Up-and-Comer for Treatment of Giant-Cell Arteritis
Oxygen-doped carbon-supported palladium nanoparticles boost the tandem hydrogenation–acetalization–hydrogenolysis of phenols and diphenyl ethers to cyclohexyl ethers
Impact of functional status and biomarkers on hospital costs and readmission rates in geriatric patients: An observational study with comprehensive geriatric assessment
This study aimed to analyze the association between functional status, biomarkers, and hospitalization characteristics on costs and the probability of re-admission at 30 and 180 days in geriatric patients. It is used an observational design with both administrative data and additional clinical data not usually collected. Multivariate linear regression for hospitalization costs and multivariate logistic regressions for readmissions were used. Variables studied included the Barthel Index, Charlson index, albumin and blood pressure levels, previous hospitalizations, length of stay (LoS), and controls. Data from 953 patients aged over 65, admitted to the Geriatric ward between September 1st, 2018, and December 31st, 2019, were analyzed. The Charlson comorbidity index, number of comorbidities, and LoS were positively related to hospitalization costs. Previous hospitalizations and LoS were the main predictors of readmission. Systolic blood pressure was negatively associated with the odds of re-admission but showed no association with hospital costs. Higher functional status, as measured by the Barthel index, was linked to lower odds of unplanned hospitalization but was not statistically significant for costs. Functional status and biomarkers had moderate effects on costs and readmission odds. These findings can aid in early healthcare planning and resource management, providing valuable information for prioritizing patients and designing cost-effective care interventions.
Selenium content and bioaccumulation in Bidens tripartita and Bidens frondosa under different habitat conditions in Poland and Montenegro
Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death
Discovery of the α-emitting isotope 210Pa
Research on anti-rollover active control of sports utility vehicle with time-delay compensation function
The global incidence of traffic accidents caused by vehicle rollovers has exhibited a persistent upward trajectory in recent years. This paper proposes a novel rollover prevention control method incorporating time-delay compensation to address inherent latency issues in anti-rollover control systems (ARCS). First, structural parameters and dynamic theory establish a three-degree-of-freedom (3-DOF) dynamics model for a sport utility vehicle (SUV). Subsequently, a lateral load transfer ratio (LTR) estimation model is developed and validated under J-turn test conditions. A grey prediction model is then implemented to forecast LTR values in advance, compensating for system time delays. A two-dimensional fuzzy controller, utilizing error and error change rate as inputs, generates corrective yaw moment through differential braking to maintain vehicle stability. Co-simulation experiments conducted in CarSim and MATLAB/Simulink under typical driving scenarios demonstrate that the proposed method effectively mitigates ARCS time delays while preserving driving stability. The results suggest this approach provides both a practical solution for SUV rollover prevention and a conceptual advancement for vehicle active safety systems, showing strong potential for real-world implementation to reduce rollover risks and enhance road safety.