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Occupational exposure to heavy metals and its association with DNA oxidative stress among urban green space workers
A geophysical investigation of the fairy circles in Nebraska for geologic hydrogen exploration
High-accuracy PM2.5 prediction via mutual information filtering and Bayesian-Optimized Spatio-Temporal Convolutional Networks
Biochemical and structural characterization of a reactive intermediate deaminase A homolog from Streptococcus sanguinis
A simple mathematical model for evaluation of non-fragmentation property of injectable calcium-phosphate cement
Abstract In this study, the mechanism of fragmentation including void formation in an injectable calcium-phosphate cement of paste-like artificial bone grafting material, is clarified from the point of view of mathematical modeling. Instead of modeling from physical laws or chemical reactions, phenomenological modeling is used, and three experiments are performed to build the model. We then successfully use the results in terms of the equations and necessary assumptions to construct a simple mathematical model. Our proposed model is based on the mathematically well-known Allen-Cahn type equation. The state of the paste is used as an unknown function. After scaling according to the appropriate nondimensionalization, numerical simulations are performed. The numerical results represent the setting behavior of the paste, which is difficult to observe experimentally. The integration of mathematical and experimental results provides deep insight into the mechanism of non-fragmentation property of an injectable calcium-phosphate cement.
Gesture recognition for hearing impaired people using an ensemble of deep learning models with improving beluga whale optimization-based hyperparameter tuning
Decoupling of industrial water consumption and economic expansion in the Yangtze River Economic Belt: a comparative analysis across three Five-Year plans
Retinoic acid receptor assembly dynamics governs dual functions in cochlear organogenesis
Retinoic acid (RA) is a morphogen that contributes to inner ear development. Gain and loss of function experiments have indicated retinoic acid’s critical role in cochlear hair cell development. However, the underlying molecular mechanisms are unclear. Here, we hypothesized that RA receptor alpha (RARA) has a dual role in cochlear organogenesis: First, during embryonic development, in the presence of RA, RARA functions as a transcriptional activator that induces prosensory gene expression in progenitor cells and supports differentiation of the organ of Corti; later during postnatal development, when RA is absent, the function of RARA switches, thereby repressing prosensory genes in postnatal hair cells and hindering trans-differentiation into supporting cells. This hypothesis was supported by demonstration that RARA forms a complex with either the coactivator NCOA1 or the corepressor NCOR1 depending on the developmental stage. In addition, modulation of RA levels was found to govern recruitment of the coactivator and corepressor to the RARA complex, and the expression of prosensory genes was validated to depend on RARA complex composition. Together, our results provide insights supporting the potential of harnessing RA signaling to induce prosensory progenitors in stem cell–based strategies for hearing loss.
The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice
Silicon nano-kirigami with controlled plastic, elastic and hysteretic deformations
Fumarylacetoacetate hydrolase targeted by a Fusarium graminearum effector positively regulates wheat FHB resistance
2D Conjugated Metal–Organic Frameworks as Electrocatalysts for Boosting Glycerol Upgrading Coupled with Hydrogen Production
Abstract The valorisation of glycerol using renewable electricity is recognised as an effective and attractive approach for producing high‐value compounds from biomass byproducts. 2D conjugated metal–organic frameworks (2D c‐MOFs) have emerged as promising electrocatalysts due to their tunable structures, high electronic conductivity, and efficient utilisation of well‐defined active centres. In this study, we report the first systematic investigation of 2D c‐MOFs containing Ni‐X 4 (X = O or N) moieties for the glycerol oxidation reaction (GOR), examining key factors influencing both electrocatalytic activity and selectivity. In situ 13 C electrochemical nuclear magnetic resonance and Raman spectroscopies provide insights into the GOR mechanism and confirm that Ni–O 4 sites are the primary active centres. Theoretical calculations further reveal that [Ni 3 (HHTQ) 2 ] n (HHTQ = 2,3,7,8,12,13‐hexahydroxytricycloquinazoline) exhibits superior GOR activity due to strong adsorption of reaction intermediates and weak interlayer interactions. This work highlights the potential of 2D c‐MOFs as highly efficient GOR catalysts, paving the way for the rational design of advanced electrocatalysts and contributing to the development of sustainable energy conversion and storage technologies.