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Prognostic value of dynamic KDIGO staging in acute kidney injury after acute heart failure: a doubly robust analysis
Coping styles moderate stress pathways to suicidal ideation in clinic-based sample of Chinese adolescents with depression
Application of weighted centroid algorithm based on weight correction in node localization of wireless sensor networks
Identification and verification of oxidative stress-related genes in the diagnosis of osteoporosis
Viral genomes track the transmission of mpox in humans before 2017 outbreak
GAINSeq: glaucoma pre-symptomatic detection using machine learning models driven by next-generation sequencing data
Donor and recipient genetic variants in drug metabolizing enzymes and transporters affect early tacrolimus pharmacokinetics after liver transplantation
Computed tomography guided high dose rate brachytherapy for induced oligoprogression of colorectal cancer liver metastases
The chain mediating role of resilience and change fatigue between intolerance of uncertainty and job burnout in nurses
Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model
Ecologically sustainable human exploitation of the Gran Dolina TD10.2 bison (Sierra de Atapuerca, Spain)
Abstract There is evidence that communal hunting of bison was a practice that occurred from the Middle Pleistocene to historic times and was also observed among Indigenous Americans. Within the subsistence strategies of Pleistocene humans, communal hunting was part of their range of behaviors. The level TD10.2-BB of the Gran Dolina in the Sierra de Atapuerca preserves a fossil record of this practice, with remains of at least 60 bison of different age classes. This study aims to evaluate the hypothesis that human exploitation of these bison was sustainable. To this end, we analyzed the mortality pattern of bison from TD10.2-BB through dental remains using ternary diagrams and life tables. We also used allometric equations to estimate the mean body mass of the bison population and the potential energy yield they could have provided. Our results suggest a catastrophic mortality profile for the TD10.2-BB bison, with individuals of all age classes and no selective bias toward specific age classes. The life table derived from this profile suggests a growing bison population, indicating that human exploitation could have been sustained without causing a population collapse. Furthermore, our results suggest that bison would provide meat and energy resources to support large groups of humans for several days. While the high protein content of bison carcasses may have limited their full utilization, the availability of other resources in the ecosystem likely facilitated the optimal use of bison.
Prolonged administration of ritodrine hydrochloride in women with premature labor or threatened premature delivery based on empirical data in Japan
Variability in seed oil content, fatty acids profile, phytochemical properties, mineral and proximate composition of Iranian cultivars of vitis vinifera L
An efficient signature aggregation scheme with antenna hardware implementation for VANETs
Abstract Vehicular ad-hoc networks (VANETs) plays a major role in enhancing road safety and traffic management. However, they suffer from security and scalability issues due to dynamic network conditions. Conventional signature aggregation schemes have high computational and communication cost limiting real-time efficiency. To overcome this issue, an efficient mutual certificateless anonymous authentication with signature aggregation is presented in this work. Moreover, a compact printed antenna using concentric octagonal rings based on the ‘Golden ratio’ principle is designed in this work. This antenna is used for the transfer of location-based information (LBI) at a frequency of 5.90 GHz inside the Dedicated Short-Range Communications (DSRC) band (802.11p) between the On-board unit (OBU) of the vehicle user and the roadside unit (RSU). Further, formal and informal security investigation shows the resistance of the proposed protocol against well-known attacks. Moreover, the efficiency of the suggested protocol is analysed in terms of security attributes, computational and communication overhead using the Cygwin platform with respect to relevant works. Finally, the performance of the designed antenna for the transfer of LBI is validated based on return loss, impedance bandwidth, gain, cross-polarization discrimination, back-lobe radiation, and radiation efficiency using the Computer Simulation Technology (CST) microwave studio (v2019).
Single nucleus RNA-seq reveals the process from onset to chronic kidney disease in IgA nephropathy
Quantification of trace 227Ac and other radionuclidic impurities in mass-separated 225Ac samples produced at CERN-MEDICIS
Abstract 225Ac is a promising candidate medical radionuclide for targeted alpha therapy of advanced stage cancers. One of the main production pathways is the high-energy proton spallation of thorium-based targets, that requires an efficient, nuclide-selective separation method to recover 225Ac from hundreds of co-produced spallation and fission products. The main radioactive contaminant of concern is 227Ac (T1/2 = 21.8 years), that could preclude extensive medical use if not significantly suppressed. In this work, 225Ac samples were produced by mass separation of radioactive ion beams extracted from proton-irradiated thorium-based targets. The activity of 225Ac and other possible contaminants of the samples were measured using complementary gamma- and alpha-decay spectrometry methods, while 227Ac activity was calculated by performing alpha-decay spectrometry of recoiled progeny from the sample. Using this novel method, accurate measurement of trace 227Ac activity in 225Ac samples was performed much faster than with conventional spectrometry techniques, thanks to its 10,000-fold increase in relative sensitivity. The end of collection activity ratio of 227Ac to 225Ac in two samples from irradiated targets were determined to be $$2.00(10) \times 10^{-6}$$ and $$2.7(4) \times 10^{-6}$$ respectively, three orders of magnitude below the 227Ac activity in 225Ac products obtained through radiochemical separation. The high separation factor of 225Ac over 227Ac suggests the suitability of mass-separated accelerator-based 225Ac for medical use.