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Deciphering the angiogenic potential of Zhishi Xiebai Guizhi decoction in coronary heart disease: an in-depth network pharmacology and experimental investigation
Hybrid attention transformer integrated YOLOV8 for fruit ripeness detection
Monitoring water crisis from space across a Mediterranean region
Substrate-dependent thermal sensing using silver nanoparticles synthesized via laser ablation in solution
<i>Mechanometallaphotoredox</i> Catalysis: Utilizing Increased Throughput Mechanochemistry to Develop Solvent-Minimized Aryl Amination and C(sp2)-C(sp3) Cross-Coupling Reactions with Increased Tolerance to Aerobic Conditions
Uncovering causal gene-tissue pairs and variants through a multivariate TWAS controlling for infinitesimal effects
Inflammation mediated glycolipid dysregulation in coronary microvascular disease pathogenesis
Machine learning model and hemoglobin to red cell distribution width ratio evaluates all-cause mortality in pulmonary embolism
Preparation and characterization of biodegradable cellulose nanofiber films modified with methylene blue and vitamin C for detecting oxidants
An improved SMOTE algorithm for enhanced imbalanced data classification by expanding sample generation space
Optimal Bi₀.₈Ba₀.₂FeO₃ doping in Bi₀.₅(Na₀.₇₇K₀.₂₀Li₀.₀₃)₀.₅TiO₃ multiferroic ceramics synthesized by the solid-state combustion technique
Locking interstitial hydrogen atoms in Pd metallenes for efficient oxygen reduction reaction
Enrichment of ornithine decarboxylase degron transduced colorectal cancer cells for extended application of cancer stem cell models
Machinability analysis of LM26 aluminium metal matrix composites reinforced with graphite and fly ash using the AWJM process
Balancing resource utilization and slice dissatisfaction through dynamic soft slicing for 6G wireless networks
Multi channel fusion diffusion models for brain tumor MRI data augmentation
The association between ionized calcium level and 28-day mortality in patients with sepsis: a cohort study
Abstract Ionized calcium is crucial for normal physiological function, and blood calcium disorders are associated with poor prognosis in various diseases. However, the relationship between ionized calcium and outcomes in sepsis patients remains understudied. This study aimed to investigate the association between ionized calcium levels and 28-day mortality in sepsis patients. This was a retrospective cohort study of patients with sepsis in the eICU Collaborative Research Database (eICU-CRD) from 208 distinct ICUs across the United States between 2014 and 2015 that explored, and ultimately we included 4,031 patients with sepsis. Ionized calcium level was the exposure variable, and 28-day mortality after ICU admission was the outcome variable. Binary logistic regression was used to explore the independent effects of ionized calcium on 28-day mortality using nonadjusted and multivariable-adjusted models. A generalized additive model and smoothed curve fitting were used to investigate the non-linear relationship between ionized calcium levels and 28-day mortality. A two-piecewise linear model was used to calculate the odds ratio (OR) and 95% confidence interval (CI) on either side of the inflection point. The remaining 4031 patients with sepsis were enrolled in the final analysis. The mean age of the patients was 64.30 ± 15.93 years, and 2167 patients (53.76%) were males. The overall incidence of 28-day death was 13.05% (526/4031). There was a nonlinear relationship between ionized calcium levels and 28-day mortality in patients with sepsis. When the ionized calcium levels were less than 4.25 mg/dL, the risk of 28-day mortality increased by 51% for every unit of decrease in ionized calcium (OR = 0.49, 95% CI 0.29–0.82, P-value = 0.0066). When the ionized calcium level was greater than 4.65 mg/dL, the risk of 28-day mortality increased by 69% for every unit of increase in ionized calcium (OR = 1.69, 95% CI 1.05–2.72, P-value = 0.0307). For patients with sepsis, the association between the ionized calcium levels and the 28-day mortality risk was a U-shaped curve. A higher or lower ionized calcium level was associated with an increased risk of 28-day mortality in patients with Sepsis.