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Characterization of Turkish mulberry genetic resources based on antioxidant capacity, biochemical composition, nutrient content, and morphological traits of leaves
Risk of pancreatic cancer according to glycemic status in nonalcoholic fatty liver disease: a nationwide cohort study
Clinical efficacy and biomechanical analysis of robotic internal fixation with percutaneous screws in the treatment of both-column acetabular fractures
Multiomics reveals metformin’s dual role in gut microbiome remodeling and hepatic metabolic reprogramming for MAFLD intervention
Bridge-Mediated Electron Transfer: Bioinspired Redox Communication for Sustained Nitrite-Independent Anaerobic Ammonium Oxidation
Demonstration of a mobile optical clock ensemble at sea
Machine learning enhanced formation pressure prediction using integrated well logging and mud logging
Glans penis electric stimulation modulates cerebral activity and functional connectivity in lifelong premature ejaculation revealed by functional MRI
Roof control effect of in situ strip interval paste backfill in goaf
Ultra-broadband actively tunable terahertz modulator based on multi-stacked metamaterial
Dynamics and genetic variation of dengue virus serotypes circulating during the 2022 outbreak in Karachi
Distribution of copy number alterations and impact of chromosome arm call thresholds for meningioma
Ag/ZnO nanodots from Artemisia austroyunnanensis as antibacterial and anticancer agents against human neuroblastoma cells
Loss of endothelial ZEB2 in mice attenuates steatosis early during metabolic dysfunction-associated steatotic liver disease
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease, features liver sinusoidal endothelial cell (LSEC) alterations with ill-defined driving factors. Zinc-Finger E-Box-binding Homeobox (ZEB)2 in LSECs preserves their specialized features, prevents capillarization and protects against liver fibrosis. To investigate a potential protective role against steatosis, the initial MASLD stage, we fed EC-specific Zeb2 knockout (EC Zeb2KO ) mice a western-type diet (WD). In healthy and steatotic wild-type livers, Zeb2 was ubiquitously and similarly expressed across blood-vascular EC types. LSEC RNA sequencing revealed ZEB2 deficiency-triggered expression changes greatly overlapping with those evoked by WD-feeding. Endothelial ZEB2-loss and WD-feeding interacted to boost capillarization and fat metabolism, shown by increased expression of continuous EC markers and peroxisome proliferator-activated receptor (PPAR)α signaling components, respectively. Altered communication among LSECs after combined endothelial ZEB2-loss and WD-exposure revealed similar functional repercussions. Endothelial ZEB2-loss eventually corrected WD-induced liver hypo-vascularization while ameliorating hepatic damage and steatosis. Thus, endothelial ZEB2-loss amplifies WD-induced LSEC fat metabolism and capillarization, while decreasing steatosis, in part through altered LSEC-LSEC communication. The disease-promoting role of endothelial ZEB2 in early MASLD as opposed to its protective role in fibrosis underscores a context-dependent effect in liver disease.
Research on engineering cost prediction based on similarity
Spin caloritronics of a quantum dot coupled to a magnetic insulator and normal metal
Abstract We investigate the generation of spin current through temperature gradients in a quantum dot-based hybrid system. In particular, we study a quantum dot coupled to a magnetic insulator and a (non)magnetic metallic electrode. Generally, each electrode is maintained at a different temperature, resulting in a finite spin current. In this system, spin current of the magnonic type is converted into electric spin current, and vice versa, depending on the direction of the temperature gradient. We examine the influence of the magnonic energy-dependent density of states and many-body magnon interactions on thermally induced spin current. Additionally, the system can work as a spin Seebeck engine, converting heat into spin current. We establish the conditions under which the system operates as a heat engine and present results on its performance. Furthermore, we propose a device based on the system that acts as an efficient thermal spin-diode–allowing spin current to pass in one direction of the temperature bias while completely suppressing it in the opposite direction.