Browse Articles
Discover research articles across all indexed journals
Scaling-up molecular logic to meso-systems via self-assembly
Abstract Due to the small size and biocompatibility of molecules, molecular logic-based computation is a gateway to the informational basis of life processes. Logic-based computation operates widely with discrete molecules of up to nanometric sizes. The contribution of molecule-based bulk materials of milli/centimetric size to the field has begun in more recent years. However, artificial molecule-based meso-scale systems which intrinsically perform logic operations are very rare. Here, we show that self-assembled systems consisting of cyclophane octacarboxylates and a cationic surfactant can perform such functions, where a membrane itself behaves as a Reset-Set Flip-Flop which is integrated with 7 more logic elements. Now that molecular logic-based computation operates across a wide range of contiguous size-scales, the way opens for its general use in information processing aspects of biology and synthetic biology.
Synthesis of iron oxide/activated hydrochar composite from residual brewery biomass for remediation of water contaminated with chlorophenol
Asymmetric S=N-embedded polyaromatic construction via enantioselective Pd-catalyzed C–H activation
Predicted climate-induced range shifts and conservation challenges of the western barbastelle bat (Barbastella barbastellus)
In-memory ferroelectric differentiator
Ultrasound guided blood brain barrier opening using a diagnostic probe in a whole brain model
Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints
How microclimate influences the spring phenological responses to decreased snow cover in four tree species seedlings in a boreal forest
Leveraging ecosystems responses to enhanced rock weathering in mitigation scenarios
Abstract Carbon dioxide removal (CDR) is deemed necessary to attain the Paris Agreement’s climate objectives. While bioenergy with carbon capture and storage (BECCS) has generated substantial attention, sustainability concerns have led to increased examination of alternative strategies, including enhanced rock weathering (EW). We analyse the role of EW under cost-effective mitigation pathways, by including the CDR potential of basalt applications from silicate weathering (geochemical CDR) and enhanced ecosystem growth and carbon storage in response to phosphorus released by basalt (biotic CDR). Using an integrated carbon cycle, climate and energy system model, we show that the application of basalt to forests could triple the level of carbon sequestration induced by EW compared to an application restricted to croplands. EW also reduces the costs of achieving the Paris Agreement targets as well as the reliance on BECCS. Further understanding requires improved knowledge of weathering rates and basalt side-effects through field testing.
Analysis of people newly diagnosed with HIV and intervention measures in Chongqing
A functional screen uncovers circular RNAs regulating excitatory synaptogenesis in hippocampal neurons
Abstract Circular RNAs (circRNAs) are an expanding class of largely unexplored RNAs which are prominently enriched in the mammalian brain. Here, we systematically interrogate their role in excitatory synaptogenesis of rat hippocampal neurons using RNA interference. Thereby, we identify seven circRNAs as negative regulators of excitatory synapse formation, many of which contain high-affinity microRNA binding sites. Knockdown of one of these candidates, circRERE , promotes the formation of electrophysiologically silent synapses. Mechanistically, circRERE knockdown results in a preferential upregulation of synaptic mRNAs containing binding sites for miR-128-3p. Overexpression of circRERE stabilizes miR-128-3p and rescues exaggerated synapse formation upon circRERE knockdown in a miR-128-3p binding site-specific manner. Overall, our results uncover circRERE -mediated stabilization of miR-128-3p as a means to restrict the formation of silent excitatory synaptic co-clusters and more generally implicate circRNA-dependent microRNA regulation in the control of synapse development and function.
Association between serum Klotho levels and thrombocytosis in aging adults based on evidence from the National Health and Nutrition Examination Survey
Spin Seebeck in the weakly exchange-coupled Van der Waals antiferromagnet across the spin-flip transition
The interpretable machine learning model for depression associated with heavy metals via EMR mining method
Highly parallel profiling of the activities and specificities of Cas12a variants in human cells
A vision attention driven Language framework for medical report generation
Beating spectral bandwidth limits for large aperture broadband nano-optics
Topology-preserving contourwise shape fusion
Astronomically calibrating early Ediacaran evolution
Abstract The current low-resolution chronostratigraphic framework for the early Ediacaran Period hampers a comprehensive understanding of potential trigger mechanisms for environmental upheavals and their connections to evolutionary innovation. Here, we establish a high-resolution astrochronological framework spanning ~57.6 million years of the early Ediacaran, anchored by the radioisotopic date of the Gaskiers glaciation onset, based on key sections from South China. Constrained by multiple radioisotopic dates, this framework precisely constrains the timing of the Marinoan deglaciation, Ediacaran Negative carbon isotope excursions 1 and 2 (EN1 and EN2), and key fossil assemblages (acanthomorphic acritarchs, Weng’an and Lantian biotas). These dates indicate the rapid termination of the Marinoan glaciation in South China within 106-107 years, while providing robust temporal evidence for the global synchroneity of EN1, EN2, and Marinoan deglaciation. The integrated chronology refines the age model for early Ediacaran biotic evolution, revealing that ecosystems gradually increased in complexity over multi-million-year timescales while global taxonomic diversity remained relatively stable, punctuated by rapid transitions to novel communities coinciding with biogeochemical perturbations.