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In vitro and in silico pharmacological effects of Rosmarinus officinalis leaf methanolic extracts and essential oils
An optimized deep learning based hybrid model for prediction of daily average global solar irradiance using CNN SLSTM architecture
γδ T cell distribution in the adventitial layer of non-fertile cystic echinococcosis cysts from cattle livers
Mediating role of self-efficacy and moral identity in volunteer service and public service motivation among Chinese college students
Bioinformatics analysis to identify key invasion related genes and construct a prognostic model for glioblastoma
Ecotoxic effect of mycogenic silver nanoparticles in water and soil environment
Abstract Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials due to their antimicrobial properties. Among the AgNPs synthesis methods, the biological route has become preferable because of its efficiency and eco-friendly character. Filamentous fungi can be successfully used in biosynthesis of AgNPs. The extensive application of AgNPs and their ever increasing production raise concerns about their environmental safety. AgNPs can be released during manufacturing processes or by leaching from AgNPs-supplemented products, and then enter the natural environment. Water and soil ecosystems are most exposed to the AgNPs presence. The present study aimed at evaluating the ecotoxicological potential of AgNPs derived from Gloeophyllum striatum fungus. The assessment was performed using organisms from water and soil ecosystems. Our results suggest that the presence of AgNPs can threaten the organisms inhabiting exposed ecosystems and the adverse effects of AgNPs differ depending on the organism species. Freshwater crustacean Daphnia magna was found to be the most sensitive among the tested species with EC50 values ranging 0.026–0.027 µg/mL after 48 h exposure. Crop plants were the least affected by the presence of AgNPs with EC50 values above tested AgNPs concentration range. Moreover, it was noted that ecotoxicological potential varied depending on the AgNPs synthesis scheme and these differences were the most visible in the case of S. polyrhiza.
Exploration of promising key electronic and nonlinear optical properties of bifluorenylidene based chromophores: a TD-DFT/DFT approach
Tillage intensity reductions when combined with yield increases may slow soil carbon saturation in the central United States
Monocyte CCL2 signaling possibly contributes to increased asthma susceptibility in type 2 diabetes
Postural stability of polish special forces operators
Antimicrobial resistance and genomic characteristics of Campylobacter spp. From Australian meat chickens with A follow up investigation
Cyanidin-3-glucoside upregulated NDRG2 through the PI3K/AKT pathway to alleviate EMT and ECM in renal fibrosis
MiR-203 improved renal cell injury in diabetic nephropathy by targeting SOCS6/SOCS7 and inhibiting JAK/STAT pathway activation
Virulence factors and biofilm forming ability of Staphyloccoccus species isolated from skeletal lesions of broiler chickens
Abstract Lameness in poultry is a significant issue in modern meat production that adversely affects both animal welfare and economic outcomes due to poor leg health, reduced locomotor function, increased feed conversion ratios, and poor performance. Fast-growing broilers are particularly susceptible to lameness, with Staphylococcus being a major bacterial cause of skeletal infections. The aim of this study was to identify Staphylococcus species isolated from skeletal lesions in broiler chickens and to characterize the factors that facilitate such infections. Bacterial strains were isolated from 25 commercial broiler flocks in eastern Poland. The median prevalence of Staphylococcus in birds per flock was 60%. In total, 47% of the examined chickens and 88% of the examined flocks tested positive for Staphylococcus. The main bone sites affected by staphylococci were the femur (56.7%), femoral head (necrosis) (34.3%), hock joints (9.0%), femoral head (transient necrosis) (9.0%), tibiotarsus (7.5%), foot pads (dermatitis) (3.0%), and stifle (knee) joints (1.5%). Of all 93 Staphylococcus strains, 59% (55/93) were isolated from the femora. Twelve staphylococcal species were identified, all coagulase-negative, where Staphylococcus cohnii (24.7%) was the most prevalent species, followed by S. epidermidis (16.1%), S. hominis (15.1%), S. lentus (10.8%), S. saprophyticus (9.7%), S. chromogenes (8.6%), S. arlettae (4.3%), S. sciuri (4.3%), S. haemolyticus (2.2%), S. xylosus (2.2%), S. carnosus (1.1%), and S. gallinarum (1.1%). Eleven and six different staphylococcal species were implicated in the pathogenesis of femoral and tibiotarsal lesions, respectively. More than one Staphylococcus species was isolated from 47.8% of all Staphylococcus-positive chickens. Nearly all (97.8%) of coagulase-negative staphylococci isolates had biofilm-forming ability, but most of them were categorized as weak biofilm producers. The highest biofilm production was observed in the strains that caused femoral head osteonecrosis and footpad dermatitis. Staphylococcus chromogenes, S. lentus, and S. epidermidis exhibited the highest DNase and/or gelatinase activity. Despite the low prevalence of certain adhesin genes, the eno gene encoding laminin-binding protein was highly represented in staphylococci (75.3%). The study highlights the complex nature of coagulase-negative staphylococcal infections in poultry and underscores the need for further research into their virulence mechanisms and control strategies.
Beta-adrenergic receptor blockers improve survival in patients with advanced non-small cell lung cancer combined with hypertension undergoing radiotherapy
Pei-Wo Drone: a home-based exercise guidance system with a drone for older adults
Identification of therapeutic targets for chronic kidney disease through Mendelian randomization analysis of druggable genes
An accurate approach to discriminate android colluded malware from single app malware using permissions intelligence
Honey bee immune response to trace concentrations of clothianidin goes beyond the macronutrients found in artificial diets
Abstract Honey bees (Apis mellifera) often encounter a variety of stressors in their environment, including poor nutrition and pesticides. These stressors interact and can be exacerbated in large-scale agroecosystems. We investigated how diets varying in macronutrient ratios can affect nurse bee susceptibility to pesticide stressors. Nurse bees were fed trace concentrations of clothianidin (CLO), a neonicotinoid insecticide known to have sublethal and lethal effects on honey bees, after newly emerged bees were given diets varying in proteins and lipids, a natural pollen diet, or sucrose solution diet. Bees given pollen had improved longevity, physiology, enzyme activity, and gene expression related to pesticide detoxification. The artificial diets helped improve bee health and physiology but did little to promote bee detoxification enzymes and genes. There was no effect of the trace CLO treatments on its own, but there was an interactive effect between our higher CLO treatment and poor nutrition on bee longevity and vitellogenin expression. Our results suggest that (1) exposure to even trace concentrations of CLO can interact with poor nutrition to undermine adult bee health and (2) macronutrients in artificial diets can help promote bee physiology, but other nutrients in pollen, such as potentially phytochemicals, are more directly linked honey bee tolerance to pesticide stress.