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A new numerical method for calculating residual deformation in mined-out areas considering water–rock interaction and its application
A deep learning framework for instrument-to-instrument translation of solar observation data
Development of low cost ZnO based chemi resistive biosensor for the detection of vitamin B6 mediated by quantum dots
Abstract In this study, we developed a chemi-resistive sensor for vitamin B6 mediated by CdTe quantum dots (Cadmium Telluride QDs) utilizing ZnO-based thin films through the spin-coating sol–gel technique annealed at 500 °C. The sensor successfully recognized vitamin B6 (Pyridoxine) in concentrations ranging from 2 to 10 µM by employing CdTe quantum dots (Cadmium Telluride QDs) on the ZnO thin film. This detection was achieved by implementing an amperometric (I–V) method, typically operating at a working voltage below 2 V. From the slope of the calibration curve, the sensitivity, and the limit of detection values are estimated to be 7.56 ± 0.92 nA/µM and 0.906 µM (n = 5), respectively. This study conducted electrochemical impedance spectroscopy (EIS) in conjunction with current–voltage (I–V) measurements. The results obtained from EIS are consistent with the current response observed in the I–V measurements. The sensing mechanism primarily relies on the charge transfer phenomenon (electrostatic attraction) between the analyte (vitamin B6 mediated by CdTe quantum dots) and the ZnO thin film. In summary, our work introduces a simple, rapid, and cost-effective ZnO thin film-based sensing device for detecting vitamin B6, mediated by CdTe QDs. This sensor holds promise for a wide range of applications, from pharmaceutical quality control to point-of-care diagnostics and routine vitamin B screening.
Bilateral in-situ functionalization towards Ah-scale aqueous zinc metal batteries
Evaluation of owners’ and veterinarians’ attitudes toward veterinarian dressing styles in a teaching hospital in Taiwan
Abstract This study examined preferences for veterinarian dressing styles from both pet owners’ and veterinarians’ perspectives. A questionnaire was distributed to investigate the attitudes of pet owners and veterinarians toward six different dressing styles, four hairstyles, and nine appearance-related subjects toward both male and female veterinarians. A total of 211 pet owners and 92 veterinarians were included. Our results indicated that veterinarian dressing style affected the first impression of pet owners. Pet owners considered wearing a white coat or surgical scrubs an appropriate dressing style for veterinarians. While owners had no sex preference for veterinarians (p < 0.001), they had different attitudes towards various hairstyle for female and male veterinarians. Although any hairstyle, except for a bald hairstyle, was regarded as appropriate for female veterinarians among owners, male veterinarians with short hairstyles were considered more appropriate than other hairstyles. Wearing glasses, a name tag, a stethoscope, a watch, or sneakers tended to leave a neutral or appropriate impression. Wearing an earring, necklace, ring, or tattoo was considered very inappropriate by some owners. Overall, the owners were stricter than the veterinarians on different hairstyles but more permissive on appearance-related subjects.
Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd)
Use of cover data to model species abundance distributions through continuous probability functions
Abstract Species abundance distribution (SAD) models describe the abundances of the species within ecological communities. SAD modelling has been developed using frequency distributions that require the use of count data (number of individuals). However, many organisms, such as most plants, cannot be counted. Instead, abundance is estimated using cover values. We show here how SAD approaches conceived for modelling frequency distributions based on counts can be modified to deal with continuous distributions and provide an application using relative plant cover as a continuous measure of abundance. We applied several SAD models using continuous probability functions to investigate how plant SADs changed along a wide (2,500 m) elevational gradient in the Alborz Mountains (Iran). We found that most communities were adequately fitted by the Weibull distribution, whose parameters changed along the gradient in response to the interplay between biotic and environmental filtering processes. The use of continuous probability functions in SAD modelling should be encouraged in research dealing with plant communities and other organisms for which counting individuals is theoretically or practically impossible.
Reactive ZIF-L Crystal Surface for Organophosphorous Degradation and Acetylcholinesterase Reactivation
Inhibition of tau neuronal internalization using anti-tau single domain antibodies
Abstract In Alzheimer’s disease, tau pathology spreads across brain regions as the disease progresses. Intracellular tau can be released and taken up by nearby neurons. We evaluated single domain anti-tau antibodies, also called VHHs, as inhibitors of tau internalization. We identified three VHH inhibitors of tau uptake: A31, H3-2, and Z70mut1. These VHHs compete with the membrane protein LRP1, a major receptor mediating neuronal uptake of tau. A31 and Z70mut1 bind to microtubule binding domain repeats, which are involved in the interaction with LRP1. VHH H3-2 is the only VHH from our library that reduces the internalization of both monomeric tau and tau fibrils. VHH H3-2 binds a C-terminal tau epitope with high affinity. Its three-dimensional structure in complex with a tau peptide reveals a unique binding mode as a VHH-swapped dimer. These anti-tau VHHs are interesting tools to study tau prion-like propagation in tauopathies and potentially develop novel biotherapies.
Investigating fracture evolution mechanisms in thick coal seam mining under upper hard and lower soft overburden: a case study
Dietary Phyllanthus Emblica inclusion regulates growth, serum biochemistry, organ histology, gene expression, and resistance against Aspergillus Flavus in Nile Tilapia (Oreochromis Niloticus)
Overexpression of Tn antigen induces chronic pancreatitis in mice
Abstract Altered O-glycosylation is a key contributor to various pathophysiological processes. Notably, the expression of the Tn antigen is primarily attributed to dysfunction of the chaperone Cosmc, while the overexpression of polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) has also been implicated in numerous diseases. We generated a transgenic mouse model with conditional Cosmc-knockout and simultaneous overexpression of polypeptide N-acetylgalactosaminyltransferase 2 (GalNT2) mediated by the pancreas-specific transcription factor 1a (Ptf1a)-Cre mouse strain to investigate the effect of Tn antigen overexpression on the pancreas in vivo. Histopathological examination of the transgenic pancreas revealed a chronic pancreatitis phenotype with interlobular fibrosis and focal necrosis after only a few weeks as a result of Tn antigen overexpression. In the later stages, there was a progressive loss of pancreatic parenchyma with consecutive exocrine pancreatic insufficiency and malnutrition in the transgenic mice. Flow cytometric analyses have also confirmed that significant infiltration of immune cells occurs in the course of pancreatitis. In the transgenic mouse model presented here, we demonstrated that overexpression of the Tn antigen in the pancreas results in chronic pancreatitis, highlighting the pathophysiological importance of truncated O-glycosylation.