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Chelerythrine triggers the prolongation of QT interval and induces cardiotoxicity by promoting the degradation of hERG channels

Journal of Biological Chemistry Fang Wang, Baoqiang Wang, Xiwei Gu et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108023

Multiple gating processes associated with the distal end of the S6 segment of domain II in the Nav channels

Journal of Biological Chemistry Minzhi Chen, Shuijiao Peng, Zhen Xiao et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108060

Dysregulation of PI4P in the trans Golgi regions activates the mammalian Golgi stress response

Journal of Biological Chemistry Kanae Sasaki, Marika Toide, Takuya Adachi et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108075

Unveiling 14 novel 2-hydroxy acid racemization and epimerization reactions in the lactate racemase superfamily

Journal of Biological Chemistry Julian Urdiain-Arraiza, Amandine Vandenberghe, Gergana Dimitrova et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108069

Fat cells have long-lasting (epigenetic) memory

Nature Reviews Molecular Cell Biology Kim Baumann Jan 01, 2025 DOI: 10.1038/s41580-024-00816-x

Histone variants: The bricks that fit differently

Journal of Biological Chemistry Youssef A. Hegazy, Hejer Dhahri, Nour El Osmani et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108048

Calcium connects lysosomal damage to stress granule formation

Nature Reviews Molecular Cell Biology Kim Baumann Jan 01, 2025 DOI: 10.1038/s41580-024-00817-w

Deep phenotyping of T regulatory cells in psoriatic arthritis highlights targetable mechanisms of disease

Journal of Biological Chemistry Tegan McTaggart, Jing Xuan Lim, Katie J. Smith et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108059

Condensates trail the nucleus

Nature Reviews Molecular Cell Biology Lisa Heinke Jan 01, 2025 DOI: 10.1038/s41580-024-00814-z

Mechanistic insights into the selective targeting of P2X3 receptor by camlipixant antagonist

Journal of Biological Chemistry Trung Thach, KanagaVijayan Dhanabalan, Prajwal Prabhakarrao Nandekar et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108109

E2F1 and E2F7 regulate gastric cancer cell proliferation, respectively, through transcriptional activation and transcriptional repression of MYBL2

Journal of Biological Chemistry Tianyi Wu, Fengli Jiang, Fan Wu et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108027

m6A ‘encodes’ a dedicated mRNA decay pathway

Nature Reviews Molecular Cell Biology Eytan Zlotorynski Jan 01, 2025 DOI: 10.1038/s41580-024-00815-y

Science in 2025: what to expect this year

Nature Benjamin Thompson, Miryam Naddaf Jan 01, 2025 DOI: 10.1038/d41586-024-04237-w

The mechanism of Ca2+-independent activation of BKCa channels in mouse inner hair cells and the crucial role of the BK channels in auditory perception

Journal of Biological Chemistry Zhong-Shan Shen, Jun Gan, Bing Xu et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.107970

Quiescent cells maintain active degradation-mediated protein quality control requiring proteasome, autophagy, and nucleus-vacuole junctions

Journal of Biological Chemistry Dina Franić, Mihaela Pravica, Klara Zubčić et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108045

Alternative splicing is an FXRα loss-of-function mechanism and impacts energy metabolism in hepatocarcinoma cells

Journal of Biological Chemistry Manon Garcia, Hélène Holota, Angélique De Haze et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108022

Three decades of protein-fragment complementation

Nature Reviews Molecular Cell Biology Stephen W. Michnick Jan 01, 2025 DOI: 10.1038/s41580-024-00813-0

An anomalous abundance of tryptophan residues in ceramide synthases based on analysis of all membrane proteins in the Swiss-Prot database

Journal of Biological Chemistry Beatriz Mestre, Iris D. Zelnik, Stav Izrailov et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108053

Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment

Nature Reviews Molecular Cell Biology Xiaofu Cao Jan 01, 2025 DOI: 10.1038/s41580-024-00808-x

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors

Journal of Biological Chemistry Thomas C. Eadsforth, Leah S. Torrie, Paul Rowland et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108049