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Aberrant Wnt/β-catenin signaling in the mesenchymal stem cells of LZTFL1-depleted mice leads to increased adipogenesis, with implications for obesity

Journal of Biological Chemistry Yunden Badralmaa, Ven Natarajan Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108057

The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap

Nature Reviews Drug Discovery Anneliene H. Jonker, Elena-Alexandra Tataru, Holm Graessner et al. Jan 01, 2025 DOI: 10.1038/s41573-024-01059-3

The mode of subunit addition regulates the processive elongation of actin filaments by formin

Journal of Biological Chemistry Biswaprakash Mahanta, Naomi Courtemanche Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108071

Two decades of new drug approvals in Japan

Nature Reviews Drug Discovery Ryosuke Kuribayashi, Aya Hariu, Yasuhiro Kishioka et al. Jan 01, 2025 DOI: 10.1038/d41573-024-00153-w

Small molecule-based regulation of gene expression in human astrocytes switching on and off the G-quadruplex control systems

Journal of Biological Chemistry Vijay Kumar M. J, Jérémie Mitteaux, Zi Wang et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108040

The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships

Nature Reviews Drug Discovery Josepine Fernow, Marie Olliver, William Couet et al. Jan 01, 2025 DOI: 10.1038/d41573-024-00138-9

One-for-all gene inactivation via PAM-independent base editing in bacteria

Journal of Biological Chemistry Xin Li, Ying Wei, Shu-Yan Wang et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108113

The steroid hormone 20-hydroxyecdysone inhibits RAPTOR expression by repressing Hox gene transcription to induce autophagy

Journal of Biological Chemistry Tian-Wen Liu, Can Tian, Yan-Xue Li et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108093

Redirecting E3 ubiquitin ligases for targeted protein degradation with heterologous recognition domains

Journal of Biological Chemistry Huan Yang, Ge Zheng, Grace Y. Li et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108077

Spatial chromosome organization and adaptation of the radiation-resistant extremophile Deinococcus radiodurans

Journal of Biological Chemistry Qin-Tian Qiu, Cai-Yun Zhang, Zhi-Peng Gao et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108068

The signaling landscape of insulin-like growth factor 1

Journal of Biological Chemistry Muhammad Zahid Khan, Jose Luis Zugaza, Ignacio Torres Aleman Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108047

Dynamic O-GlcNAcylation coordinates etoposide-triggered tumor cell pyroptosis by regulating p53 stability

Journal of Biological Chemistry Jing Wang, Yida Wang, Huan Xiao et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108050

Thrombin confers chemotherapeutic resistance by promoting transcriptional induction and post-translational stabilization of pro-survival MCL1 in TNBC

Journal of Biological Chemistry Subhojit Paul, Akash Chatterjee, Kaushik Das et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108025

Structural basis for the pathogenicity of parkin catalytic domain mutants

Journal of Biological Chemistry Julian P. Wagner, Véronique Sauvé, Anshu Saran et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108051

A conserved acidic residue drives thyroxine synthesis within thyroglobulin and other protein precursors

Journal of Biological Chemistry Camilla Stejskalova, Federica Arrigoni, Riccardo Albanesi et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108026

Inhibition of the neddylation E2 enzyme UBE2M in macrophages protects against E. coli-induced sepsis

Journal of Biological Chemistry Xuehuan Wen, Songjie Bai, Guirun Xiong et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108085

Purification of micrococcal nuclease for use in ribosomal profiling of high-salinity extremophiles

Journal of Biological Chemistry Pavlina Gregorova, Matthew Isada, Jocelyne DiRuggiero et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108020

mRNA vaccine sequence and structure design and optimization: Advances and challenges

Journal of Biological Chemistry Lei Jin, Yuanzhe Zhou, Sicheng Zhang et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108015

Iron regulatory protein 1-deficient mice exhibit hypospermatogenesis

Journal of Biological Chemistry Aileen Harrer, Niraj Ghatpande, Tiziana Grimaldini et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108067

Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits

Journal of Biological Chemistry Therése Klingstedt, Hamid Shirani, Farjana Parvin et al. Jan 01, 2025 DOI: 10.1016/j.jbc.2024.108032