Browse Articles

Association between lifestyle risk factors and mortality in the Mexico City prospective study

Determinants of outcomes in patients with hepatitis B virus-decompensated cirrhosis

FSTL1 aggravates high glucose-induced oxidative stress and transdifferentiation in HK-2 cells

Galectin 9 rescues the inducibility of IL-10 expression in regulatory B cells of patients with food allergy

The effect of PEO/NaCl dual porogens in the fabrication of porous PCL membranes via a solid-state blending approach

The presence of pleural effusion is an independent prognostic factor in patients with malignant pleural mesothelioma

Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET

Vitality insights of fish escaping from a sorting grid installed on a bottom trawl net

Abstract Sorting grids to exclude the juveniles of species targeted by bottom trawl fisheries from the catch are among the most promising solutions to reduce discards. We tested a two-sections Juveniles’ Sorting Grid (JSG) in a Mediterranean fisheries restricted area. First, we provided information on the vitality of individuals escaping from the JSG bars during towing, by analysing underwater footage. Then, we evaluated the catch performance of the JSG-equipped trawl compared to a standard trawl by analysing both the full species community in the catches and the main commercial species. The probability for individuals to be alive while escaping from JSG was always higher than 65% (on average), with some species (e.g. red mullet, gurnards, 91–99% on average) showing significantly higher probability than others (e.g. European hake, crustaceans, 65–82% on average). The installation of a JSG in the trawl net did not change the overall catch composition in the codend, although significant differences were observed at the single species level. The JSG was effective at reducing undersized individuals of European hake, although a loss of legal-sized individuals was observed due to escapement. A significantly lower retention of the JSG-equipped trawl was also observed for other commercial species, such as deep-water rose shrimp and broadtail shortfin squid.

CoGraphNet for enhanced text classification using word-sentence heterogeneous graph representations and improved interpretability

Influence of phonon anharmonicity on Raman spectra of Cu2ZnSn(S,Se)4 polycrystalline thin films through computational study

Looking for social pragmatic communication disorder in the complex world of Italian special needs: an exploratory study

Modelling Euphrates river water quality index based on field measured data in Al-Diwaniyah City, Iraq

Compact wearable microstrip antenna design using hybrid quasi-Newton and Taguchi optimization

Enhancing the performance of SSVEP-based BCIs by combining task-related component analysis and deep neural network

Differential effects of structurally different lysophosphatidylethanolamine species on proliferation and differentiation in pre-osteoblast MC3T3-E1 cells

AbstractLysophosphatidylethanolamine (LPE) is a bioactive lipid mediator involved in diverse cellular functions. In this study, we investigated the effects of three LPE species, 1-palmitoyl LPE (16:0 LPE), 1-stearoyl LPE (18:0 LPE), and 1-oleoyl LPE (18:1 LPE) on pre-osteoblast MC3T3-E1 cells. All LPE species stimulated cell proliferation and activated the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) 1/2. MAPK/ERK1/2 activation by 16:0 LPE and 18:1 LPE was inhibited by the Gq/11 inhibitor YM-254890, while activation by 18:0 LPE was blocked by the Gi/o inhibitor pertussis toxin. Intracellular Ca2+ transients were triggered by 16:0 LPE and 18:1 LPE but not by 18:0 LPE, with YM-254890 suppressing these responses. These results suggest that 16:0 and 18:1 LPE act via Gq/11-coupled G protein coupled receptors (GPCRs), and 18:0 LPE acts via Gi/o-coupled GPCRs. Furthermore, receptor desensitization experiments suggested that each LPE acts through distinct GPCRs. Interestingly, 18:0 LPE suppressed osteogenic differentiation, reducing mineralization, alkaline phosphatase activity, and osteogenic gene expression, whereas 16:0 LPE and 18:1 LPE had no such effects. These results suggest the physiological significance of LPEs in bone formation and indicate that different LPE species and their receptors play distinctive roles in this process.

Effect of stearic acid and sodium stearate on hydrophobicity of nano calcium carbonate and mechanism of water vapor adsorption

Optimal voltage and frequency control strategy for renewable-dominated deregulated power network

AbstractMaintaining stable voltage and frequency regulation is critical for modern power systems, particularly with the integration of renewable energy sources. This study proposes a coordinated control strategy for voltage and frequency in a deregulated power system comprising six Generation Companies (GENCOs) and six Distribution Companies (DISCOs). The system integrates thermal, diesel, wind, solar photovoltaic (PV), and hydroelectric sources. Two stochastic modeling techniques are used to characterize wind and solar generation, accounting for their variability within the control loops. A novel Leader Harris Hawks Optimization-based Model Predictive Controller (MPC-LHHO) is implemented, achieving a reduction in frequency deviation undershoot by 67.45% and voltage settling time by 91.11% compared to conventional controllers under poolco and bilateral transactions. Auxiliary devices, including the Unified Power Flow Controller (UPFC) and grid-connected electric vehicles (EVs), further enhance performance, reducing frequency deviations by 52.18% under stochastic scenarios. Rigorous evaluation under contract violations, random load variations, and renewable intermittency demonstrates the strategy’s robustness and efficacy.

Clonal shift and impact of azithromycin use on antimicrobial resistance of Staphylococcus aureus isolated from bloodstream infection during the COVID-19 pandemic

Optimizing electrode configurations for EEG mild cognitive impairment detection

A secure and energy-efficient routing using coupled ensemble selection approach and optimal type-2 fuzzy logic in WSN

AbstractWireless sensor networks (WSNs) are imperative to a huge range of packages, along with environmental monitoring, healthcare structures, army surveillance, and smart infrastructure, however they’re faced with numerous demanding situations that impede their functionality, including confined strength sources, routing inefficiencies, security vulnerabilities, excessive latency, and the important requirement to keep Quality of Service (QoS). Conventional strategies generally goal particular troubles, like strength optimization or improving QoS, frequently failing to provide a holistic answer that effectively balances more than one crucial elements concurrently. To deal with those challenges, we advocate a novel routing framework that is both steady and power-efficient, leveraging an Improved Type-2 Fuzzy Logic System (IT2FLS) optimized by means of the Reptile Search Algorithm (RSA). This modern framework employs weighted ensemble clustering and matched ensemble choice techniques, facilitating strong cluster formation and resulting in a substantial 98% development in community lifetime, an 80% enhancement in packet delivery ratio (PDR), and a 45% reduction in average power consumption while as compared to current protocols. The IT2FLS model dynamically adapts routing selections by means of assessing key parameters, consisting of dynamic accept as true with factors, node power ranges, course delays, and energy consumption fees, whilst the RSA algorithm exceptional-tunes the bushy common sense club features to make certain most beneficial cluster head choice and reliable multi-hop communication paths. Additionally, our proposed technique complements secure routing by means of efficaciously counteracting the effects of compromised nodes, for this reason maintaining community integrity. Multiple test results show that RSA’s enhanced IT2FLS system consistently outperforms new standards. It reduces end-to-end work by 25% and significantly increases productivity. These findings suggest that this robust routing model not only guarantees efficient data transmission and performance. But it also guarantees the stability of the overall network. This research contributes significantly to the WSN field by providing a comprehensive routing solution that integrates energy conservation, security, and QoS, ultimately extending the lifespan of WSNs and boosting confidence in critical applications, paving the way for implementation scenarios that require secure, low-power, and real-time data transmission.