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An urban road traffic flow prediction method based on multi-information fusion
Enriched grain minerals in Aegilops tauschii-derived common wheat population under heat-stress environments
Impact of the right ventricular mechanical pattern assessed by three-dimensional echocardiography on adverse outcomes following cardiac surgery
Abstract Risk stratification for cardiac surgery is a cornerstone of perioperative management. While the prognostic impact of severe right ventricular (RV) dysfunction is well understood, the added value of the RV mechanical pattern regarding risk prediction remains unknown. We sought to prospectively validate the predictive value of 3D RV mechanics for adverse perioperative outcomes. The clinical and echocardiographic parameters of 439 retrospectively selected patients who underwent various types of cardiac surgery and 3D transesophageal echocardiography were investigated to determine their associations with a composite endpoint of an unfavorable postoperative outcome. Tricuspid regurgitation, 2D RV strains, and 3D measures of left ventricular (LV) and RV function were associated with the composite endpoint. Multivariable logistic regression models revealed that only tricuspid regurgitation, LV ejection fraction and 3D RV global longitudinal strain (GLS) were independently associated with the endpoint. By applying the model to the data of 128 prospectively enrolled patients, only 3D RV GLS remained an independent predictor. A RV GLS cutoff of -17.4% was found to be associated with a 3-fold increased risk for adverse outcomes. This led us to conclude that RV longitudinal deformation derived from 3D echocardiography is predictive of adverse outcomes and should be incorporated in perioperative risk stratification.
Adaptive laboratory evolution of Micrococcus luteus and identification of genes associated with radioresistance through genome-wide association study
Extracellular vesicles efficiently deliver survival motor neuron protein to cells in culture
Utility of a commercial antibody against NTRK1 for western blotting and potential application to immunohistochemistry in adult mouse brain
Severe plastic deformation of Al strips through equal multi and single channel angular pressing
Abstract Equal channel multi-angular pressing (ECMAP) and equal channel angular pressing (ECAP) of Al-1050 strips were carried out. The ECMAP and ECAP load-displacement behavior, peak load, microhardness distribution maps, homogeneity, and average values were investigated. Finite element simulations (FEM) of the ECMAP and ECAP were performed using the DEFORM-3D program. The experimental and FEM load-displacement curves were close to each other, with deviations between the FEM and experimental peak loads of 2.3–9.5 and 0.9–3.1% in the ECMAP and ECAP. The ECAP experimental and FEM peak loads were lower by 149.4-163.4 and 127.9-151.8% than that of the ECMAP after one to three passes. FEM average effective plastic strain was obtained with high accuracy in the different plans. The ECAP sample’s deformation homogeneity was higher by 19-62.6% relative to that of ECMAP samples. The microhardness results verify the 3D FEM simulation one that ECAP samples have a higher deformation homogeneity. Moreover, the average microhardness values of ECAP samples were higher by 4.5–13.3% than the ECMAP samples in the different plans. ECAP processing of Al-1050 strips is recommended rather than using ECMAP to produce large samples with a higher degree of deformation homogeneity and microhardness.
Comparison of hepatocellular carcinoma incidence after long-term treatment with besifovir vs. tenofovir AF
Reservoir computing-based signal compensation for laser inter-satellite communications
A new analogous organ in bony fishes and amphibians: an anatomical structure related with the cerebrospinal fluid circulation
CT based 3D radiomic and clinical airway examination model for evaluating mask ventilation in oral and maxillofacial surgery patients
Leclercia barmai sp. nov., isolated from worm castings of Eisenia fetida, is a urease-positive, 3-nitropropionic acid and glycerol-consuming bacterium
METTL14 suppresses the migration and invasion of hepatocellular carcinoma cells by m6A methylation of RPLP2
Monocationic versus dicationic-based monomethine cyanine dyes for ultrasensitive colorimetric detection of hypochlorite ion in water
Abstract Detecting residual chlorine as a hypochlorite ion (ClO−) in drinking water is crucial for ensuring disinfection effectiveness and safety. In the present study, we report two novel Quinolium Benzothiazole-Based Cyanine (3ethylbenzothiazol-2(3 H)-ylidene)methyl)-1-(4-iodobutyl)quinolin-1-ium tetrafluoroborate (IBTQ) and 1-(3-(4-(dimethylamino)pyridin-1-ium-1-yl)propyl)-4-((3-methylbenzothiazol-2(3 H)-ylidene)methyl)quinolin-1-ium diiodide (DMP-BTQ) hypochlorite (ClO−) sensors using UV- visible, colorimetric, and quartz crystal microbalance (QCM) techniques. The two sensors generate distinct absorption spectra, frequency shifts, and color changes that are visible to the naked eye. They exhibit high sensitivity and selectivity towards ClO−. The sensors have limits of detection (LOD) values in the range of 13.92 ppm and 0.127 ppm for IBTQ and DMP-BTQ, respectively, based on absorption performance with no interference of potential ions in drinking water. The method yields good recovery results, ranging from 97.4 to 103.0%, for ClO− detection in the studied water samples. In addition, the LOD for the QCM technique is 0.06 ppm for IBTQ and 0.045 ppm for DMP-BTQ with low quantification. The sensors can be loaded on paper strips for naked-eye detection of ClO− in domestic tap water and water treatment facilities. The sensors also provide low-cost, low cytotoxicity, high sensitivity, selectivity, and reusability of ClO− in water. The sensing mechanism was rationalized in terms of radical cation generation upon ClO− oxidizing action. The ease of cyanine oxidation was substantiated by quantum chemical studies including density functional theory (DFT) calculations, natural bond orbital (NBO) analysis, molecular electrostatic potential (MESP), and time-dependent density functional theory to support the experimental results.
Theoretical analysis of lipase-enzymatic DKR model for racemic (R)- and (S)- ibuprofen ester in a hollow cylindrical membrane bioreactor
Abstract This study examines the semi-analytical expression of a hollow cylindrical fiber membrane bioreactor catalyzed by an immobilized enzyme (lipase), focusing on the dynamic kinetic resolution (DKR) of racemic (R)- and (S)-ibuprofen ester through the homotopy perturbation method (HPM). This method effectively solves the coupled non-linear system of second-order ordinary differential equations (ODEs), incorporating the mass transfer associated with the DKR reaction rate. The DKR rate equations are computed utilizing both enantiomers, which represent the enzymatic hydrolysis of the substrate within the barrier’s support matrix, where the racemization term is negligible. Additionally, the corresponding racemization of the unreacted substrate outside the membrane is considered, where the enzymatic hydrolysis term is negligible. The dimensionless steady-state solution for the dynamics of the mean integrated effectiveness factor (MIEF) related to convective hydrolysis-racemization phenomena quantifies the local effectiveness factor, which impacts the Thiele modulus and the bulk initial concentrations of a substance within the membrane layer. The Bodenstein number is a critical parameter that optimizes reaction conditions, enhances mixing efficiency, and mitigates mass transfer limitations. The normalized values from the sensitivity analysis are analyzed to identify the key parameters of the present system. The conversion efficiency and limitations of the proposed model utilizing HPM are presented. Our proposed solution compares the semi-analytical expression with the simulated numerical results of BVP-4c using the built-in solver in MATLAB R2023b software, demonstrating good agreement across all values of the reaction parameters. The agreement between semi-analytical and numerical computations demonstrates the validity of these approximation methods. The findings provide significant insights for enhancing membrane reactor design and improving the efficiency of industrial processes for racemic ibuprofen ester production.
Adaptive variable channel heat dissipation control of ground control station under various work modes
Projection of climate change impact on the occurrence of drought events in Poland
Abstract In the era of human-induced climate change, droughts are one of the extreme events that can severely impact water resources, regional agriculture and the ecological environment. A reliable projection of droughts for the future is crucial with the rapid global increase in the frequency and intensity of droughts. This research aims to project the future of droughts in Poland by the end of the 21st century. To achieve this, we use a multi-model mean ensemble of 26 downscaled and bias-corrected high-resolution general circulation models (GCMs) under Shared Socioeconomic Pathways (SSP1–2.6, SSP2–4.5, SSP3–7.0, and SSP5–8.5) scenarios from Coupled Model Intercomparison Project Phase 6 (CMIP6) to project changes in temperature and precipitation. Then, estimation of droughts was completed for the periods 2031–2060 and 2071–2100 according to the Standardized Precipitation Evapotranspiration Index (SPEI) at three-time scales of 1, 6 and 12 months to address three types of droughts (i.e., meteorological, agricultural and hydrological, respectively). The temperature and precipitation projection revealed that temperature will increase in both future periods, which is dramatic under the SSP3–7.0 and SSP5–8.5 scenarios. However, precipitation fluctuates based on scenarios with a slight increase, excluding far-future periods under SSP3–7.0, and SSP5–8.5 scenarios. The projected changes in droughts based on SPEI under SSP scenarios showed a decrease in frequency in the near-future, but an increase under SSP2–4.5, SSP3–7.0 and SSP5–8.5 in the far-future. The number of severe and moderate droughts is expected to rise, with a notable increase in agricultural and hydrological droughts (SPEI-6 and SPEI-12) under SSP3–7.0 and SSP5–8.5.