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Long non-coding RNA NEAT1 promotes colorectal cancer progression via interacting with SIRT1
BRD4 interacting genes as prognostic biomarkers in hepatocellular carcinoma for optimized treatment strategies
Effects of dual intake channels on energy efficiency and emissions of the uniflow scavenging opposed-piston engine
Objective and subjective suicidal intent are differentially associated with attempt lethality based on age of onset of suicidal behavior
Changes in physical fitness in acute leukemia patients during chemotherapy
Joint analysis of time-varying effect of vaccine and antiviral drug for preventing severe complications and mortality
Singlet fission in heterogeneous lycopene aggregates
Rurality and relative poverty drive acquisition of a stable and diverse gut microbiome in early childhood in a non-industrialized setting
Abstract There are limited longitudinal data from non-industrialized settings on patterns and determinants of gut bacterial microbiota development in early childhood. We analysed epidemiological data and stool samples collected from 60 children followed from early infancy to 5 years of age in a rural tropical district in coastal Ecuador. Data were collected longitudinally on a wide variety of individual, maternal, and household exposures. Extracted DNA from stool samples were analysed for bacterial microbiota using 16S rRNA gene sequencing. Both alpha and beta diversity indices suggested stable profiles towards 5 years of age. Greater alpha diversity and lower beta diversity were associated with factors typical of rural poverty including low household incomes, overcrowding, and greater agricultural and animal exposures. Consumption of unpasteurized milk was consistently associated with greater alpha diversity indices. Delivery method and antibiotic exposures during pregnancy and early childhood appeared to have limited effects on developmental trajectories of gut microbiota. Infants living in a non-industrialized setting in conditions of greater poverty and typically rural exposures appeared to acquire more rapidly a stable and diverse gut bacterial microbiome during childhood.
Deep learning-based organ-wise dosimetry of 64Cu-DOTA-rituximab through only one scanning
Effect of PM2.5 exposure on susceptibility to allergic asthma in elderly rats treated with allergens
Classification patterns identification of immunogenic cell death-related genes in heart failure based on deep learning
9-aminominocycline potentiates the efficacy of EIDD-1931 and PF-332 by targeting the papain like protease enzyme of SARS-CoV-2
Conflict-based strategy combined integrated optimal conflict avoidance algorithm
Performance of the Nottingham hip fracture score (NHFS) as a predictor of 30-day mortality after proximal femur fracture in an older people Brazilian cohort
The complexity of comorbidity distribution and pathogenesis in the elderly based on a dependency network simulation
Cognitive function moderates the mediation of resilience in the relationship between perceived receipt of filial piety and loneliness among community-dwelling older adults with multiple long-term conditions
Circular intuitionistic fuzzy Hamacher aggregation operators for multi-attribute decision-making
Long-lived photoexcitation probed by photo-induced enhanced Raman spectroscopy: unveiling charge dynamics in Ag–TiO2 nano-heterojunctions
Abstract This work explores Photo-Induced Enhanced Raman Spectroscopy (PIERS) as a tool to investigate charge carrier dynamics in nanometer-thick Ag–TiO2 heterojunctions with a Schottky barrier. Due to the light-induced charge transfer process at the semiconductor–metal interface, PIERS provides a significant signal enhancement over traditional Surface-Enhanced Raman Spectroscopy (SERS). In turn, a remarkably stable PIERS signal lasting over 10 days after UVC light illumination cannot be explained exclusively by the presence and the lifetime of the induced oxygen vacancies, so other features of the Ag–TiO2 heterojunction must be responsible for this effect. Time-resolved Raman spectroscopy, photoluminescence (PL), UV–Vis, XPS, and I–V characterization were used to explore charge migration mechanisms further to prove PIERS applicability. While PL showed rapid healing of oxygen vacancies, the correlation of the PIERS signal with changes in the Schottky barrier height and relative changes in the electron density under various lighting conditions indicates that both Hot Electron Injection (HEI) and Plasmon-Induced Resonance Energy Transfer (PIRET) are responsible for the Raman signal changes over time. We showed that both phenomena can be probed by in situ PIERS spectroscopy. This proof-of-principle paves the way for developing more advanced photoactive semiconductor–metal composites suitable for energy conversion or storage, as well as SERS and PIERS analytics.
Assessing the clinical reliability of short-term heart rate variability: insights from controlled dual-environment and dual-position measurements
Abstract Heart rate variability (HRV) is a widely recognized biomarker for autonomic nervous system regulation, applicable in clinical and athletic settings to monitor health and recovery. Despite its extensive use, HRV measurement reliability is influenced by numerous factors, necessitating controlled conditions for accurate assessments. This study investigates the reliability of short-term HRV measurements in various settings and positions, aiming to establish consistent protocols for HRV monitoring and interpretation. We assessed morning HRV in 34 healthy, physically active adults across supine and standing positions, at home and in the laboratory, over a 24-hour period. Environment significantly impacted standing HRV. Home measurements exhibited slightly lower variance compared to lab settings, underscoring the importance of environment control. Our findings confirm the high reliability of HRV measurements, indicating their robustness in capturing autonomic changes, provided a rigorous methodology is employed. Here we show that effective and reliable HRV assessment is possible across various conditions, contingent upon strict management of confounding factors. This research supports the utility of HRV as a non-invasive diagnostic tool, emphasizing its importance in health management and potential in broadening applications to diverse populations. Future studies are encouraged to expand these assessments to include varied demographic and clinical profiles, enhancing HRV integration into routine health evaluations.