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Angiogenesis-promoting effect of SKP-SC-EVs-derived miRNA-30a-5p in peripheral nerve regeneration by targeting LIF and ANGPT2

Journal of Biological Chemistry Mi Shen, Xinli Ye, Qiang Zhou et al. Feb 01, 2025 DOI: 10.1016/j.jbc.2024.108146

Nest site selection during the second breeding attempt in Japanese tits (Parus minor): effects of nest site characteristics

Scientific Reports Xudong Li, Jiangping Yu, Li Zhang et al. Feb 01, 2025 DOI: 10.1038/s41598-025-87928-2

Liver fatty acid binding protein FABP1 transfers substrates to cytochrome P450 4A11 for catalysis

Journal of Biological Chemistry Kevin D. McCarty, F. Peter Guengerich Feb 01, 2025 DOI: 10.1016/j.jbc.2025.108168

Validation of histopathology foundation models through whole slide image retrieval

Scientific Reports Saghir Alfasly, Ghazal Alabtah, Sobhan Hemati et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88545-9

PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration

Scientific Reports Weixing Xu, Rana Dhar, Danyang Zheng et al. Feb 01, 2025 DOI: 10.1038/s41598-025-87639-8

Fully automated CFD simulation system research based on design scheme tree

Scientific Reports Zijun Liu Feb 01, 2025 DOI: 10.1038/s41598-024-83582-2

Abstract Compared with the remarkable achievements of computer-aided drug discovery systems for drug discovery, the role of computational fluid dynamics (CFD) in flow channel design requires further development. While CFD has undergone rapid evolution, the absence of integrated geometry and mesh processing hinders the potential development of advanced applications of this technology. To overcome this limitation, in this paper, the JIACFD toolset is presented, and a fully automated CFD simulation system is established. The simulation system is also constructed on a design scheme tree, which is more in accordance with engineering logic. The control parameter trend analysis method is introduced to select appropriate candidates from the design scheme tree. Additionally, the control parameter trend assumption, which is proven via the Spearman method, is proposed to improve the efficiency of the system. During the verification process for the study case, two independent control parameters exhibit correlating trends, and one control parameter converges when the number of meshes increases, indicating a lack of trend sensitivity. The design scheme tree and trend curve are subsequently utilized to effectively analyze the flow field characteristics of different schemes. Finally, the control parameter trend analysis method is employed to rank the design scheme tree and verify that the ranking of candidates is not dependent on the number of meshes. This paper investigates and verifies the presented system, method, and assumption and explores the possibility of an established system playing a more critical role in performance design work.

Targeting lysine acetylation readers and writers

Nature Reviews Drug Discovery Ming-Ming Zhou, Philip A. Cole Feb 01, 2025 DOI: 10.1038/s41573-024-01080-6

Association between sarcopenia components and depressed mood varies by sex among community-dwelling older adults from the Korean Frailty and Aging Cohort Study

Scientific Reports Yong Soon Park, Keunjoong Yoo, Hye Jin Kim et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88437-y

Application of chokeberry biochar as a modified additive to the vegetable lubricants: the tribological and rheological properties

Scientific Reports Rafal Kozdrach, Pawel Radulski Feb 01, 2025 DOI: 10.1038/s41598-025-87374-0

Atractylenolide I prevents acute liver failure in mouse by regulating M1 macrophage polarization

Scientific Reports Hui Zhang, Min Gao, Haiyan Wang et al. Feb 01, 2025 DOI: 10.1038/s41598-025-86977-x

Association between Healthy Eating Index-2020, alternative Mediterranean Diet scores, and gastrointestinal cancer risk in NHANES 2005–2018

Scientific Reports Weijie Wang, Yu Chang, Geng Chen Feb 01, 2025 DOI: 10.1038/s41598-025-88317-5

On QSPR analysis of pulmonary cancer drugs using python-driven topological modeling

Scientific Reports Huiling Qin, Mazhar Hussain, Muhammad Farhan Hanif et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88419-0

Habitat conservation enhances the resilience of the lizard Liolaemus cuyumhue to high summer temperatures

Scientific Reports María Victoria Brizio, Facundo Cabezas-Cartes, Luciano Javier Avila et al. Feb 01, 2025 DOI: 10.1038/s41598-024-83845-y

Analysis of anxiety and pain in patients undergoing immediate sequential bilateral cataract surgery or unilateral cataract surgery

Scientific Reports Suji Hong, Hyemi Shin, WooJin Kim et al. Feb 01, 2025 DOI: 10.1038/s41598-025-87359-z

Exploring the feasibility and clinical impact of ultrasound microvascular flow imaging in detecting brain injury in hyperbilirubinemia neonates

Scientific Reports Shuang He, Meiyu Wang, Man Zhu et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88007-2

AI-based prediction of androgen receptor expression and its prognostic significance in prostate cancer

Scientific Reports Jiawei Zhang, Feng Ding, Yitian Guo et al. Feb 01, 2025 DOI: 10.1038/s41598-025-88199-7

Optimizing AI models to predict esophageal squamous cell carcinoma risk by incorporating small datasets of soft palate images

Scientific Reports Kotaro Waki, Katsuya Nagaoka, Keishi Okubo et al. Feb 01, 2025 DOI: 10.1038/s41598-025-86829-8

MFIEN: multi-scale feature interactive enhancement network for seismic data denoising in desert areas

Scientific Reports Tie Zhong, Yuxin Ye Feb 01, 2025 DOI: 10.1038/s41598-025-87481-y

Proteins that assemble co-translationally lean on their partner for stability

Nature Reviews Molecular Cell Biology Kim Baumann Feb 01, 2025 DOI: 10.1038/s41580-024-00824-x

RNA communication between organisms inspires innovative eco-friendly strategies for disease control

Nature Reviews Molecular Cell Biology Rachael Hamby, Qiang Cai, Hailing Jin Feb 01, 2025 DOI: 10.1038/s41580-024-00807-y