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Controlling Interlayer Disorder Toward Reversible Phase Transition in a Layered Sodium Manganese Oxide Cathode
Engineering the Lewis Acidity of Fe Single-Atom Sites via Atomic-Level Tuning of Spatial Coordination Configuration for Enhanced Oxygen Reduction
Enhancing Selective Hydrofluorocarbon Greenhouse Gas Capture via Halogenation of Metal–Organic Frameworks
Self-Assembled Subwavelength Nanophotonic Structures for Spatial Object Localization and Tracking
The Role of Interfaces and Charge for Chemical Reactivity in Microdroplets
Chemical Synthesis Reveals Pathogenic Role of <i>N</i>-Glycosylation in Microtubule-Associated Protein Tau
Optimization, application effects and improved microecology of a composite microbial agent containing oyster shells
Three-Coordinate Iron(0) Complex-Catalyzed Regioselective C–H Alkylation of Indole Derivatives
The effect of cysteine oxidation on conformational changes of SARS-CoV-2 spike protein using atomistic simulations
Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet
Early detection of feline chronic kidney disease via 3-hydroxykynurenine and machine learning
Enabling Thermally Stimulated Delayed Phosphorescence in Cu(I) Cyclic Trinuclear Complexes with Near-Unity Quantum Yield
Study on energy-autonomous technology for energy consumption performance and climate adaptation in independent public toilets based on DesignBuilder simulation
If your heart stops, this smartwatch-AI can call for help
Copper-Catalyzed Selective Amino-alkoxycarbonylation of Unactivated Alkenes with CO
Acute effects of footwear and surface condition on sport specific performance in athletes
Abstract This study examined the acute effects of minimalist shoes, standard sport shoes, and barefoot conditions on sports-specific performance in forty-eight team and racket sport athletes across three testing sessions. Biomechanical laboratory assessments included 90° cutting maneuvers (90°COD) and jump tests. Linear (LS) and multidirectional sprint (MS) performances were evaluated in a second session on an indoor sports floor. In the third session, LS and MS performance were tested exclusively in minimalist shoes on tartan and artificial turf. Performance was quantified as test completion time and jump height. Significant footwear effects were observed for 90°COD, MS, and LS, with minimalist shoes and barefoot conditions reducing performance by up to 9% compared to standard sport shoes. Jumping performance was unaffected by footwear. Surface conditions significantly influenced LS and MS, with tartan and artificial turf improving performance by up to 9% compared to indoor surfaces. Significant sex differences were observed in all tests except for 90°COD. These findings suggest that the effects of footwear are context-dependent and should not be generalized without considering specific surfaces, movements, and individual factors. Future research should investigate whether long-term habituation can alter these outcomes.
Polyelectrolyte Membrane Enables Highly Reversible Zinc Battery Chemistry via Immobilizing Anion and Stabilizing Water
Ultralow Coordination Copper Sites Compartmentalized within Ordered Pores for Highly Efficient Electrosynthesis of <i>n</i>-Propanol from CO<sub>2</sub>
Inhibition of autophagy in platelets as a therapeutic strategy preventing hypoxia induced thrombosis
Abstract Hypoxia triggers activation of platelets, leading to thrombosis. If not addressed clinically, it can cause severe complications and fatal consequences. The current treatment regime for thrombosis is often palliative and include long-term administration of anticoagulants, causing over-bleeding risk and other secondary effects as well. This demands a molecular understanding of the process and exploration of an alternative therapeutic avenue. Interestingly, recent studies demonstrate that platelets exhibit functional autophagy. This cellular homeostatic process though well-studied in non-platelet cells, is under-explored in platelets. Herein, we report autophagy activation under physiologically relevant hypoxic condition (10% O2; associated with high altitude) in ex-vivo platelets and in vivo as well. We show that autophagy inhibition using chloroquine (CQ), a repurposed FDA-approved drug, can significantly reduce platelet activation, both in ex-vivo and in-vivo settings. Further, surgical ligation of inferior vena cava (IVC) was performed to induce thrombus formation. Interestingly, CQ pre-treated rats showed reduced clotting ability in surgical animals as well. Importantly, thrombosis inhibitory dose of CQ was considerably lower than the currently used drug-acetazolamide; CQ was also found to be non-toxic to the tissues. Hence, we propose that repurposing of CQ can attenuate hypoxia-induced thrombosis through inhibition of autophagy and can be explored as an effective therapeutic alternative.