Browse Articles

Harmine promotes axon regeneration through enhancing glucose metabolism

Journal of Biological Chemistry Ruixuan Liu, Bing Zhou Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108254

An engineered palivizumab IgG2 subclass for synthetic gp130 and fas-mediated signaling

Journal of Biological Chemistry Christoph Wittich, Julia Ettich, Marcel Hertell et al. Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108205

Drug resistance–associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity

Journal of Biological Chemistry Cameron J. Smith, Heledd Eavis, Carla Briggs et al. Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108266

Correction: Three prime repair exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural, and conformational properties

Journal of Biological Chemistry Prem Prakash, Purva Khodke, Muthukumar Balasubramaniam et al. Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108213

Biochemical and biophysical characterization of inositol-tetrakisphosphate 1-kinase inhibitors

Journal of Biological Chemistry Martin Y. Ng, Huanchen Wang, Haibo Zhang et al. Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108274

The common murine retroviral integration site activating Hhex marks a distal regulatory enhancer co-opted in human early T-cell precursor leukemia

Journal of Biological Chemistry Joyce Hardwick, Javier Rodriguez-Hernaez, Giovanni Gambi et al. Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108233

Synthetic mycolates derivatives to decipher protein mycoloylation, a unique post-translational modification in bacteria

Journal of Biological Chemistry Emilie Lesur, Yijie Zhang, Nathalie Dautin et al. Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108243

Phosphodiesterase 5 expression in photoreceptors rescues retinal degeneration induced by deregulation of membrane guanylyl cyclase

Journal of Biological Chemistry Alexander M. Dizhoor, Shinya Sato, Zhuokai Luo et al. Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108265

GCIP and SIRT6 cooperatively suppress ITGAV gene expression by modulating c-myc transcription ability

Journal of Biological Chemistry Yi-Ching Huang, Tien-Ming Yuan, Bang-Hung Liu et al. Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108314

Tackling pressure fluctuations in ultra-HPLC to robustly resolve and analyze polar metabolites

Journal of Biological Chemistry James R. Krycer, Manuel Plan, Thomas Stoll et al. Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108283

Multivalent nucleosome scaffolding by bromodomain and extraterminal domain tandem bromodomains

Journal of Biological Chemistry Michael D. Olp, Karina L. Bursch, Sarah L. Wynia-Smith et al. Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108289

Surface hydrophobic clusters modulate the folding stability and molecular recognition of the disintegrin jarastatin

Journal of Biological Chemistry Ariana A. Vasconcelos, Russolina B. Zingali, Fabio C.L. Almeida Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108294

P3 site-directed mutagenesis: An efficient method based on primer pairs with 3′-overhangs

Journal of Biological Chemistry Negar Mousavi, Ethan Zhou, Arezousadat Razavi et al. Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108219

Taste receptor type 1 member 3 in osteoclasts regulates osteoclastogenesis via detection of glucose

Journal of Biological Chemistry Anna Yoshimura, Takuma Matsubara, Nao Kodama et al. Mar 01, 2025 DOI: 10.1016/j.jbc.2025.108273

Genetic determinants of inflammatory cytokines and their causal relationship with inflammatory disorders of breast: a two-sample Mendelian randomization study

Scientific Reports Hongxia Wei, Hongbo Ge, Ying Qian et al. Mar 01, 2025 DOI: 10.1038/s41598-025-91723-4

Can large, simple trials bring drug developers back to common diseases?

Nature Reviews Drug Discovery Asher Mullard Mar 01, 2025 DOI: 10.1038/d41573-025-00030-0

In silico exploration of novel EGFR-targeting compounds: integrative molecular modeling, docking, pharmacokinetics, and MD simulations for advancing anti-cervical cancer therapeutics

Scientific Reports Auwal Salisu Isa, Adamu Uzairu, Umar Meleh Umar et al. Mar 01, 2025 DOI: 10.1038/s41598-025-91135-4

First muscle-growing antibody heads to the FDA, with obesity opportunities on the horizon

Nature Reviews Drug Discovery Ken Garber Mar 01, 2025 DOI: 10.1038/d41573-025-00029-7

Multimodal trajectory prediction for intelligent connected vehicles in complex road scenarios based on causal reasoning and driving cognition characteristics

Scientific Reports Zhiyong Yang, Jun Yang, Yu Zhou et al. Mar 01, 2025 DOI: 10.1038/s41598-025-91818-y

Approvals by the China NMPA in 2024

Nature Reviews Drug Discovery Xiecheng Zhi, Qiu Li, Liming Shao Mar 01, 2025 DOI: 10.1038/d41573-025-00028-8