Browse Articles

Assessing creep and creep recovery performance of plastic processed aggregate based concrete

Amide-Based Cathode Interfacial Layer with Dual-Modification Mechanisms Enables Stable Organic Solar Cells with High Efficiency Achieving 20%

Enhanced novelty approaches for resource allocation model for multi-cloud environment in vehicular Ad-Hoc networks

Halogen Bond Strength in Solids Quantified via Zeeman-Perturbed Nuclear Quadrupole Resonance Spectroscopy

Metabolic phenotype of bovine blood-derived neutrophils is altered in milk

Abstract In a healthy udder, immune cells from the peripheral bloodstream migrate into mammary tissue in low numbers to provide baseline immune surveillance, without triggering inflammation. In bovine intramammary inflammation, on the other hand, high amounts of leukocytes are recruited, causing severe inflammation. We were interested in leukocyte subpopulations and functional differences between blood- and milk-derived neutrophils from healthy and inflamed udder quarters. In this context, we found a distinct leukocyte subpopulation profile dependent on the health status of mammary gland quarters, with a predominant T cells population in heathy mammary gland quarters and a shift to macrophages and granulocytes in inflammation. Further, we detected divergent expression of major histocompatibility complex class II and interleukin 2 receptor CD25 on the surface of milk- and blood-derived neutrophils, pointing to antigen presentation and immune modulatory properties. Moreover, we observed differences in production of reactive oxygen species, deviant early and late apoptosis and functional changes in these cells, pointing to an altered metabolic phenotype in milk cells dependent on the health status of mammary gland quarters. These findings provide insights into the functional adaptations of neutrophils in different environments, highlighting the importance of metabolic alterations for immune cell function.

Development and validation comparison of multiple models for perioperative neurocognitive disorders during hip arthroplasty

Kinetically Trapped Nanocrystals with Symmetry-Preserving Shapes

Modeling of sand-cultivated substrate for Gobi facility agriculture and validation of trenching test

Regulating Cell–Material Interfacial Interactions through Selective Cellular Resistance

Increased primary breast tumor expression of CD73 is associated with development of bone metastases and is a potential biomarker for adjuvant bisphosphonate use

Modular Access from Acrylate to a Sustainable Polyester Platform with Large-Span Tunability and Chemical Circularity under Mild Conditions

Oculomotor learning is evident during implicit motor sequence learning

Predicting coronavirus disease 2019 severity using explainable artificial intelligence techniques

Giant Enhancement of Optical Nonlinearity by Manipulating Guest Molecular Stacking Modes in Metal–Organic Frameworks

Vitamin B12 as an epidrug for regulating peripheral blood biomarkers in long COVID-associated visuoconstructive deficit

A new concept and surgical approach for Chiari malformation type I based on the protection and strengthening of the myodural Bridge

IMU-Based quantitative assessment of stroke from gait

Deep-Red and Ultrafast Photocatalytic Proximity Labeling Empowered <i>In Situ</i> Dissection of Tumor-Immune Interactions in Primary Tissues

Comparing the efficacy and safety of cryoablation and microwave ablation in treating paravertebral metastases of rabbit VX2 tumor

Application of a 3D printed wig protection device after decompressive craniectomy