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Self-referencing surface plasmon sensor for resolution enhancement
The efficacy and safety of FOLFOX therapy for advanced esophageal squamous cell carcinoma
Antibiofilm activity of Plumbagin against Staphylococcus aureus
Publisher Correction: Binary composite crossover genetic algorithm for locating critical slip surface
A survey and partial dependency analysis to assess residential solid waste recycling awareness in Saudi Arabia
Author Correction: Signature-based intrusion detection using machine learning and deep learning approaches empowered with fuzzy clustering
The analysis of sanshan island based on constrained magnetization vector inversion
The new bilastine eye drop formulation protects against conjunctival dehydration and promotes corneal wound healing in a comparative in vitro study
Creep evolution characteristics and deformation mechanisms of carbonaceous slate under the action of groundwater
Abstract The carbonaceous slate exhibits significant creep characteristics and large deformations during tunnel excavation, especially in groundwater-rich areas. Studying the creep characteristics and deformation mechanism of carbonaceous slate under the influence of groundwater is substantial and essential. Triaxial creep tests of dry and saturated rock samples at different bedding angles were performed to examine the deformation characteristics using the GCTS-RTX1000 test system. The layered surface morphology was analyzed before and after the creep to reveal the deformation mechanisms. The results showed that the softening effect of water causes a significant reduction in the strength of the carbonaceous slates. The transient deformation of saturated samples was greater than that of dry samples due to the water absorption in the pores at a low-stress state. Creep in the saturated rock samples is more pronounced in the first stage compared to the dry samples, and the gap decreases as the stress increases. In the creep processes, the saturated samples manifested the pressure dissolution, debris migration, and deposition in the stratified surface of the particle skeleton under the water and the stress. These results are helpful for better understanding the creep characteristics of the carbonaceous slate in water-rich areas.
Total hip arthroplasty for crowe type IV developmental dysplasia of the hip using a dual mobility acetabular cup
ALM adjusted by BMI or weight predicts adverse health outcomes in middle-aged and elderly patients with type 2 diabetes
RSM and AI based machine learning for quality by design development of rivaroxaban push-pull osmotic tablets and its PBPK modeling
The research on landslide detection in remote sensing images based on improved DeepLabv3+ method
Multi-grained pooling network for age estimation in degraded low-resolution images
Effectiveness and safety of stellate ganglion block with trioxygen autologous blood retransfusion therapy for facial postherpetic neuralgia in elderly patients
Hemotropic mycoplasmas (hemoplasmas) in indigenous populations and their dogs living in reservation areas, Brazil
The ‘very moment’ when UDG recognizes a flipped-out uracil base in dsDNA
Abstract Uracil-DNA glycosylase (UDG) is the first enzyme in the base-excision repair (BER) pathway, acting on uracil bases in DNA. How UDG finds its targets has not been conclusively resolved yet. Based on available structural and other experimental evidence, two possible pathways are under discussion. In one, the action of UDG on the DNA bases is believed to follow a ‘pinch-push-pull’ model, in which UDG generates the base-flip in an active manner. A second scenario is based on the exploitation of bases flipping out thermally from the DNA. Recent molecular dynamics (MD) studies of DNA in trinucleosome arrays have shown that base-flipping can be readily induced by the action of mechanical forces on DNA alone. This alternative mechanism could possibly enhance the probability for the second scenario of UDG-uracil interaction via the formation of a recognition complex of UDG with flipped-out base. In this work, we describe DNA structures with flipped-out uracil bases generated by MD simulations which we then subject to docking simulations with the UDG enzyme. Our results for the UDG-uracil recognition complex support the view that base-flipping induced by DNA mechanics can be a relevant mechanism of uracil base recognition by the UDG glycosylase in chromatin.