Browse Articles

Parameter calibration for discrete element simulation of Leymus chinensis seeds based on RSM optimization

Integrating transcriptome and metabolome analyses to characterize flower development in Salix variegata franch., a typical dioecious plant

Bias dependent band alignment in Ga2O3 ferroelectric interface by operando HAXPES

Early prediction of postpartum dyslipidemia in gestational diabetes using machine learning models

Correlation free large-scale probabilistic computing using a true-random chaotic oscillator p-bit

A lagrangian particle tracking approach of evapotranspiration partitioning to explore evaporation and transpiration travel time distributions in the root zone

Single-stage versus two-stage resection for large anterior midline skull base meningiomas with bihemispheric peritumoral edema

Abstract Resection of large anterior midline skull base meningiomas with extensive peritumoral edema poses high risks due to postoperative edema decompensation leading to increased intracranial pressure. Initial craniectomy prevents intracranial pressure decompensation but requires secondary cranioplasty. This study compares single-stage osteoplastic craniotomy with tumor resection to a two-stage approach using bifrontal craniectomy, tumor resection and subsequent cranioplasty after edema recovery in a second surgical step. Patients with large anterior midline skull base meningiomas (> 50 mm) and extensive peritumoral edema were included. Group 1 underwent single-stage resection (2002–2016), while Group 2 had a two-stage approach (2012–2022). The primary outcome was the Karnofsky Performance Scale (KPS) at three months post-surgery. Secondary outcomes included preoperative KPS, KPS at discharge and last follow-up, ICU stay, hospital stay length and complication rates. A total of 25 patients were analyzed (Group 1: n  = 9; Group 2: n  = 16). Group 2 demonstrated significantly improved KPS at three months postoperatively (median KPS 70% vs. 50%; p  = 0.0204) with a non-significant reduction in ICU stay (10 vs. 6.5 days; p  = 0.3284). Although no significant differences were observed in KPS at discharge (Group 1: KPS 30% vs. Group 2: KPS 50%; p  = 0.1829) or last follow-up (Group 1: KPS 60% vs. Group 2: KPS 80%; p  = 0.1630), Group 2 patients required fewer postoperative interventions for complications unrelated to cranioplasty. Overall complication rates were comparable in both groups (Group 1: 67% vs. Group 2: 56%; p  = 0.6274). Two-stage resection of large anterior midline skull base meningiomas with extensive edema provides superior clinical outcomes at three months postoperatively without increasing overall complication rates. These findings support the use of a two-stage surgical strategy for highly selected patients. However, further multicenter studies are warranted to validate these results in larger cohorts.

Clinical and brain functional correlates of instrumental rigidity measurement in Parkinson’s disease

Parental influence on Chinese childhood cancer survivors’ physical activity: a mixed methods study

Machine learning enhanced immunologic risk assessments for solid organ transplantation

Development of a leaf metabolite-based intact sample distinguishing algorithm for the three varieties of Panax Vietnamensis

Nonreciprocal bipartite and tripartite entanglement in cavity-magnon optomechanics via the Barnett effect

Neural similarity and interaction success in autistic and non-autistic adolescents

Abstract High-quality social interactions promote well-being for typically developing and autistic youth. One factor that may contribute to the quality of social interactions is neural similarity, a metric which may capture shared perspectives and experiences of the world. The current research investigates relations between neural similarity to peers and day-to-day interaction success as measured through ecological momentary assessment in a sample of autistic and non-autistic youth aged 11–14 years old. Neural similarity was operationalized as the between-participant correlation of participants’ neural response to naturalistic video stimuli in areas of the brain implicated in mental state understanding and reward processing. Neural similarity did not have a main effect on interaction success. However, across the full sample, neural similarity significantly interacted with reported closeness, such that there were more positive relations between neural similarity and interaction success for closer interactions. Neural similarity also marginally interacted with social partner (i.e., interactions featuring peers versus others) to predict interaction success, suggesting more positive relations between neural similarity and interaction success in peer interactions. In addition, non-autistic youth reported significantly better peer interactions than autistic youth. These findings suggest that similarity to one’s peers in neural processing in mentalizing and reward regions is important for understanding interaction success. They also highlight the challenge peer interactions may pose for autistic youth and propose novel links between peer interaction success and the brain’s mentalizing processes.

Defining the concept of physical resilience and quantifying recovery during standing balance in middle-aged and older adults

Author Correction: Assessing the role of dryness and burning sensation in diagnosing laryngopharyngeal reflux

Prognostic model for log odds of negative lymph node in locally advanced rectal cancer via interpretable machine learning

Spatial pattern of attractiveness and road network accessibility of scenic spots in Guangdong Province based on network information

The pattern change of hepatitis B virus genetic diversity in Northwestern Tanzania

The suberin transporter StABCG1 is required for barrier formation in potato leaves

Abstract Suberin is a hydrophobic biopolymer that acts as an internal and external diffusion and transpiration barrier in plants. It is involved in two phases of wound healing, i.e. initial closing layer formation and subsequent wound periderm development. Transcriptomic and metabolomic analyses of wounded potato leaf tissue revealed preferential induction of cell wall modifying processes during closing layer formation, accompanied by a highly active defense response. To address the importance of suberin in this process, we generated loss of function mutants by CRISPR-Cas9 editing the suberin transporter gene StABCG1. Both wound-induced StABCG1 transcript levels and suberin formation around wounded leaf tissue were reduced in CRISPR-lines. Moreover, wound-induced tissue damage was characterized by browning of wound-adjacent areas. Transcriptome analyses of these areas revealed up-regulation of genes encoding defense proteins and enzymes of the phenylpropanoid pathway. Levels of hydroxycinnamic acid amides, acting in defense and in cell wall reinforcement, were drastically enhanced in CRISPR compared to control plants. These results suggest that the reduction in suberin formation around wounded tissue leads to a loss of barrier function, resulting in tissue browning due to enhanced exposure to oxygen.

Attachment is in the eye of the beholder: a pupillometry study on emotion processing