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Two Artificial Leaf Architectures for Solar Formate Production From CO <sub>2</sub> and H <sub>2</sub> O

Angewandte Chemie International Edition Kunpeng Yu, Bo Shang, Qi Sun et al. Jul 01, 2026 DOI: 10.1002/anie.2703193

ABSTRACT Sunlight‐powered artificial leaves for the production of formate from CO 2 are an attractive route to solar fuels, yet existing solar formate devices remain low in performance, and their architecture and material choices are underexplored. Herein, we report the fabrication of two distinct fully integrated, self‐standing solar formate device architectures and elucidate the underlying design principles and material selection strategies. The first architecture integrates a Si photocathode with a BiVO 4 photoanode and utilizes a highly active Pd catalyst for CO 2 reduction. It represents the first artificial leaf device comprising two photoelectrodes (excluding photovoltaic [PV]‐biased electrodes) for effective formate production under single‐beam illumination. The second architecture employs a dark cathode and a dark anode driven by a 4‐junction perovskite solar cell and uses a highly stable Bi catalyst for CO 2 reduction. This device delivers a record‐high formate production rate of 174 µmol h −1 with a remarkable solar‐to‐formate energy efficiency of 2% among all artificial leaf devices reported to date. These results demonstrate the feasibility and outline the design principles of both PV‐free and PV‐assisted device architectures in solar fuel production.

Pontocerebellar hypoplasia linked mutations of the deadenylase Target of EGR1 (TOE1) impair thermal stability, ribonuclease activity, and oligomerization

Journal of Biological Chemistry Lizette Zavala, Magdalena Sobien, Cassandra K. Hayne Jul 01, 2026 DOI: 10.1016/j.jbc.2026.113186

Disentangling Electronic and Strain Effects in Core–Shell Pd@Pt Catalysts

Journal of the American Chemical Society Qihao Li, Zixiao Shi, Michael Rebarchik et al. Jul 01, 2026 DOI: 10.1021/jacs.6c00086

GALNT7-induced O-glycosylation of NUP50 activates fatty acid β-oxidation to promote lung adenocarcinoma metastasis

Journal of Biological Chemistry Meiling Sheng, Beiwei Yu, Qunzhi Wang et al. Jul 01, 2026 DOI: 10.1016/j.jbc.2026.113179

Organocatalytic Desymmetric Carbon–Carbon Bond Cleavage of Unstrained Cyclohexanones

Journal of the American Chemical Society Wei-Yi Zhang, Yu-Hao Wang, Xing-Yu Zhu et al. Jul 01, 2026 DOI: 10.1021/jacs.6c03890

Lauric acid engages an O-GlcNAc–sensitive BCKDH regulatory node to modulate branched-chain amino acid oxidation in skeletal myotubes.

Journal of Biological Chemistry Koichiro Sumi, Miho Shioyama, Kinuyo Munakata et al. Jul 01, 2026 DOI: 10.1016/j.jbc.2026.113345

Accessing Medium-Sized Bridged Heterocycles via EnT-Catalyzed Intermolecular Dearomative (5 + 4) Cycloaddition of Furans and Oxazoles

Journal of the American Chemical Society Carla Hümpel, Debanjan Rana, Sophie Korgitzsch et al. Jul 01, 2026 DOI: 10.1021/jacs.6c00671

Catalytic Selective Deoxygenation and Deamination of Amides to Access Alkenes

Angewandte Chemie International Edition Qiu Shi, Wenbo H. Liu Jul 01, 2026 DOI: 10.1002/anie.4999077

ABSTRACT Amide derivatizations are important and useful transformations in organic chemistry, owing to the ready accessibility of amides. However, reported methodologies to date have been limited to either deoxygenative or deaminative pathways; the direct, single‐step conversion of amides into hydrocarbons has remained elusive. In this work, by employing 9‐borabicyclo[3.3.1]nonane (9‐BBN) as the reductant and Cp 2 ZrCl 2 as a precatalyst, we demonstrate that amides can be efficiently converted to alkenes under simple and mild conditions, which represents the third mode of amide derivatization after deoxygenation and deamination. Mechanistic investigations reveal that 9‐BBN is crucial for the tandem C─O and C─N cleavage. This transformation links the two fundamental functional groups such that the richness of amide retrosynthesis is applied to alkenes.

KMT2D depletion promotes KRAS-induced pancreatic carcinogenesis independent of TP53

Journal of Biological Chemistry Ezequiel J. Tolosa, Glancis L. Raja Arul, Ashley N. Sigafoos et al. Jul 01, 2026 DOI: 10.1016/j.jbc.2026.113203

Interaction of Molecular Hydrogen on α-Pu at 300 K: Nucleation of Hydrides and Pu-Catalyzed Carbides

Journal of the American Chemical Society Daniel J. Rodriguez, Timothy J. Gorey, Raymond Atta-Fynn et al. Jul 01, 2026 DOI: 10.1021/jacs.6c03998

Correction: A Single Chondroitin 6-Sulfate Oligosaccharide Unit at Ser-2730 of Human Thyroglobulin Enhances Hormone Formation and Limits Proteolytic Accessibility at the Carboxyl Terminus

Journal of Biological Chemistry Marisa Conte, Alessia Arcaro, Daniela D'Angelo et al. Jul 01, 2026 DOI: 10.1016/j.jbc.2026.113172

Metal‐Free Photocatalytic CO <sub>2</sub> Reduction to Formate Driven by Visible Light via a Consecutive Photoinduced Electron Transfer Mechanism

Angewandte Chemie International Edition Xianjun Yin, Jingjie Hu, Heng Wu et al. Jul 01, 2026 DOI: 10.1002/anie.1083625

ABSTRACT Realizing efficient and selective photocatalytic CO 2 reduction (PCO 2 R) using metal‐free organic systems under visible light remains a significant challenge. Here, we report the first metal‐free, self‐sensitized molecular photocatalyst capable of driving visible‐light‐induced CO 2 ‐to‐HCOO − conversion via a consecutive photoinduced electron transfer (ConPET) mechanism. The rationally designed BPI‐OMe, featuring an electron‐donating group, demonstrates exceptional performance under visible light irradiation, achieving a formate production rate of 27.51 mmol g −1  h −1 with &gt; 99% selectivity. This outstanding activity stems from its optimized electronic properties: a low excitation energy (2.98 eV), a long‐lived charge‐separated anion radical state ( τ = 806.94 ns), a high‐energy SOMO level (−3.47 eV), and strong CO 2 binding affinity (−0.147 eV). In situ ESR and ultrafast spectroscopic analyses reveal the ConPET process: sequential photon absorption enables electron transfer from ascorbic acid to BPI‐OMe, generating BPI‐OMe, followed by electron delivery to CO 2 to form CO 2 − , which is subsequently converted to formate through a hydrogen atom transfer. This work not only represents a breakthrough in metal‐free PCO2R but also provides a general molecular design strategy based on multi‐photon charge accumulation for enabling challenging solar‐to‐chemical transformations.

Prion propagation is controlled by discrete structural regions of PrP rather than overall stability

Journal of Biological Chemistry Savroop K. Bhamra, Parineeta Arora, May Liew et al. Jul 01, 2026 DOI: 10.1016/j.jbc.2026.113157

Interrogating Cholinergic Chemical Transmission of U-87 MG Glioblastoma Cells with Nanoelectrochemistry

Journal of the American Chemical Society Siao-Han Huang, Mahmuda Akter, Conrad B. Milton et al. Jul 01, 2026 DOI: 10.1021/jacs.6c04969

HSP90 Inhibition Partially Rescues Alternative Splicing Dysregulation in Cell Models of Myotonic Dystrophy

Journal of Biological Chemistry Jing Zhang, Amy Mascorro, Humayra Oishi et al. Jul 01, 2026 DOI: 10.1016/j.jbc.2026.113354

X-ray-Triggered Prodrug Activation in a Nanoscale Metal–Organic Framework for Spatially Confined Chemoradiotherapy

Journal of the American Chemical Society Yuxuan Xiong, Yibin Mao, Chenghua Deng et al. Jul 01, 2026 DOI: 10.1021/jacs.6c03407

A biosensor platform for scalable and live detection of PYY hormone production from enteroendocrine cells with single-event resolution

Journal of Biological Chemistry Aanya Hirdaramani, Gary Frost, Aylin C. Hanyaloglu Jul 01, 2026 DOI: 10.1016/j.jbc.2026.113367

Atomic Alignment in PbS Nanocrystal Superlattices with Compact Inorganic Ligands via Reversible Oriented Attachment of Nanocrystals

Journal of the American Chemical Society Ahhyun Jeong, Aditya N. Singh, Josh Portner et al. Jul 01, 2026 DOI: 10.1021/jacs.6c00744

Engineering internally His-tagged ESX secretion system fusion antigens for tuberculosis nanoparticle vaccines

Journal of Biological Chemistry Wen-Ling Hsu, Yang Jiao, Wei-Chiao Huang et al. Jul 01, 2026 DOI: 10.1016/j.jbc.2026.113337

Phase Engineering of Pd–Te Hexagonal Nanoplates for Enhancing Nitrogen Oxidation

Journal of the American Chemical Society Pinlin Wang, Fei Xue, Xubin Ye et al. Jul 01, 2026 DOI: 10.1021/jacs.6c04881