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Detection of coal seam floor failure depth through borehole direct current resistivity monitoring
Abstract Accurately monitoring mining-induced floor failure depth during coal seam extraction remains a critical technical challenge for preventing water inrush disasters. To address the limitations of existing methods—including low efficiency in borehole observation and insufficient resolution in geophysical detection—this study proposes a floor failure depth monitoring technique based on the borehole direct current (DC) electrical method. By deploying electrodes within boreholes, this approach directly acquires high-resolution resistivity profiles along vertical sections. Numerical simulations were first conducted to reveal the dynamic evolution patterns of apparent resistivity in mining-disturbed floor failure zones. Subsequently, field implementation at a typical coal mine demonstrated the methodology‘s effectiveness through monitoring electrical property variations in floor strata during pre-mining, active mining, and post-mining stages. Key quantitative results include: an identified floor failure depth of 27 m, a fracture angle of 50°, and a clear correlation with the 35 m roof caving interval. Under the layered geological model with an electrode spacing of 2 m and a borehole dip angle of 30° as set in this study, the depth identification accuracy of the variation-rate method is improved by 40–60% compared with conventional apparent resistivity imaging, which can serve as a reliable risk assessment tool for water inrush prevention in deep mining operations.
Neuroprotective effect of metformin in experimental optic neuritis in rats
Annular layered airspace design in dense urban obstacle environments
Nicotinamide mononucleotide enhances semen quality during chilled storage of maguan hornless goat: mitigating oxidative damage at 4 °C
Robust and generalizable atrial fibrillation detection from ECG using time-frequency fusion and supervised contrastive learning
Finite element thermoelastic analysis of functionally graded spherical shells
Associations of sustainable and healthy nutrition, perceived stress, and brain fog with academic performance among university students
Context-sensitivity and longitudinal stability of the effects of depressive symptoms on social and reward decision-making
Effect of modeling liquid and glycerin application protocols on the surface roughness and microhardness of one shade resin composites
Effects of diets containing fish proteins or poultry proteins on one-carbon metabolites in domestic dogs. A randomised, double-blind, two-period cross-over study
Abstract Disturbances in the one-carbon metabolic pathways are linked with several diseases, and an elevated homocysteine concentration is correlated with increased risk for developing cardiovascular diseases. Fish intake reduces homocysteine concentration in some studies, whereas little is known whether other metabolites in the one-carbon pathways are affected. Most pre-clinical studies utilise rodents, but domestic dogs may be a superior alternative model for research on human nutrition. The aim of this study was to compare the effects of diets containing proteins from herring or poultry on serum concentrations of homocysteine and related one-carbon metabolites in domestic dogs. Forty home-living golden Retrievers and Labrador Retrievers were included and received each of the two experimental diets for eight weeks in this cross-over trial. Thirty-five dogs were included in the biochemical and statistical analyses. Within-group changes were compared using the Mann-Whitney U Test. The serum concentrations of homocysteine, sarcosine, cystathionine and serine were reduced after intake of either herring or poultry protein diets, with no differences between the groups. The serum betaine concentration was increased by both diets, with a more pronounced increase after poultry protein intake, whereas choline concentration was not affected by either diet. Methionine and cysteine concentrations were not affected by herring protein, but were decreased and increased, respectively, after poultry protein intake. The glycine concentration was reduced by both diets. Both herring and poultry proteins affected the one-carbon metabolism, with only marginal differences between the diets.
Sustainable computational fluid dynamics optimization of heat sink performance for energy efficient device cooling
Graduating without a thesis: meet the people getting ‘practical’ PhDs in China
Corneal allogenic intrastromal ring segments for the treatment of keratoconus
Extracellular vesicle-derived candidate biomarker in metabolic dysfunction-associated steatotic liver disease: systematic review and exploratory meta-analysis
Abstract Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) is raising global concern, highlighting the need for simple, reliable, and non-invasive diagnostic tools. Extracellular vesicles (EVs) are well-known nano-carriers of circulating biomarkers, which are often involved in disease development and intercellular communication. The current review aims to synthesise and analyse the evidence from the exploratory diagnostic studies examining the EV-derived biomarkers in MASLD. A detailed literature search across three electronic databases, including PubMed, Scopus, and Embase, resulted in 3440 records, of which 7 eligible studies were selected for further data synthesis. Quality assessment for the included studies was carried out adhering to Minimal Information for Studies of Extracellular Vesicles (MISEV) guidelines. The meta-analysis was performed using unique analytic strategies, including area under the curve (AUC)-based analyses for EV-derived panels and biomarkers in MASLD. The meta-analysis results indicated that the diagnostic accuracy associated with the plasma-derived EV microRNAs (miRNAs) was considerable for the exploratory studies and needs further validation for clinical practice. Overall, systematically synthesised evidence suggests that the EV-derived miRNAs might serve as clinically useful diagnostic biomarkers for early-stage MASLD. However, the exploratory nature of the literature, which involved high heterogeneity across the study design, sample processing, and analysis, caused difficulty in generalising the conclusions, thus suggesting the need for standardisation. Overall, the present review provides a detailed synthesis of exploratory research, emphasising the diagnostic value of EV-derived biomarkers.
ITPRIPL1: A tumor immune-associated biomarker with prognostic and therapeutic implications in gastrointestinal cancer
SMARCA2 and SMARCA4-deficiency is associated with a distinct molecular and microenvironmental subtype of esophageal adenocarcinoma
Abstract Dysregulation of chromatin remodeling is a key driver of malignant progression. The SWI/SNF ATPase subunits SMARCA2 and SMARCA4 are essential for chromatin dynamics, yet the clinicopathological and microenvironmental landscape of SMARCA2/4-deficient esophageal adenocarcinoma (EAC) remains insufficiently defined. We analyzed 722 resected EACs from a large Western cohort. SMARCA2 and SMARCA4 status were assessed by immunohistochemistry, and tumors were classified as SMARCA-intact or SMARCA-deficient (complete loss of nuclear expression in tumor cells with internal controls). Molecular co-alterations were evaluated by immunohistochemistry and fluorescence in situ hybridization, including amplifications of MET , ERBB2 (HER2) , EGFR , PIK3CA , MYC , MDM2 , TERT , and Y-chromosome loss (LOY). Several markers were available from prior works. Digital pathology workflows quantified CAF markers (SMA, PDGFRβ, FAP, Periostin, Tenascin) and immune infiltrates (including CD4, CD8, FOXP3, CD20, MUM1, mast cell tryptase). Overall survival was examined using Kaplan–Meier estimates and Cox regression models. SMARCA2/4-deficient tumors accounted for 11.2% of the cohort (81/722) and were enriched among patients aged ≥ 65 years. SMARCA-deficient EACs showed a significantly higher frequency of MET amplification (16.9%), particularly after neoadjuvant therapy. Within SMARCA-deficient tumors, PDGFRβ-positive CAFs, increased plasma cell (MUM1+) and mast cell infiltrates correlated with a favorable outcome, whereas loss of Y-chromosome (LOY) identified an adverse-risk subgroup with particularly poor prognosis. This largest-to-date study defines SMARCA-deficient EAC as a distinct subtype characterized by frequent MET amplification and high-risk interaction with LOY, alongside prognostically relevant stromal-immune features, supporting refined biomarker-based risk stratification and therapeutic exploration.