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Enhanced Q learning and deep reinforcement learning for unmanned combat intelligence planning in adversarial environments
Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease
Lattice Distortion Promoting Wavelength‐Tunable Emissions in Cu(I)‐Based Halides for Thermography and Anti‐Counterfeiting
Abstract Low dimensional hybrid metal halides as a chemically tunable platform achieve multi‐functional optical applications with versatile luminescence mechanisms. Herein, we design and prepare Cu(I)‐based hybrid halide (DMAP)Cu 3 I 4 (DMAP = 4‐Dimethylaminopyridine), with ambient temperature‐induced photoluminescence evolution from red to near‐infrared emissions. The in situ variable‐temperature crystallographic study reveals lattice distortion with more disordered [Cu 3n I 4n ] n− units appear at high temperature, further indicating that the observed wavelength‐tunable emission is attributed to transitions from Cu cluster center to halogen‐to‐metal charge transfer. Thus, (DMAP)Cu 3 I 4 shows a compelling thermometric precision (high sensitivities of 0.0001–0.6 K −1 ) at a wide temperature range of 80–300 K. In particular, the remote thermography is established with a high spatial resolution of −20 lp mm −1 by processable thin films. These findings enhance the potential for molecular‐level illumination in Cu(I)‐based halides and contribute to the exploration of their optoelectronic properties.
Internet of things enabled deep learning monitoring system for realtime performance metrics and athlete feedback in college sports
Computational identification of small molecules for increased gene expression by synthetic circuits in mammalian cells
Caffeine-augmented exercise as a pretreatment for locomotor and balance impairments induced by REM sleep deprivation in rats
Molecular spin sensor for in-situ monitoring of crystallization behavior and phase transition in aromatic materials
Virulence and genome analysis of baculovirus isolates from different Lymantria dispar populations
Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking
Science populism impacts perceptions of credibility across scientific professions
The spatial landscape of glial pathology and T cell response in Parkinson’s disease substantia nigra
A novel passive shimming optimization method of MRI magnet based on a PSA-SQP hybrid algorithm
Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosis
Abstract Healthy alveolar repair relies on the ability of alveolar stem cells to differentiate into specialized epithelial cells for gas exchange. In chronic fibrotic lung diseases such as idiopathic pulmonary fibrosis (IPF), this regenerative process is abnormal but the underlying mechanisms remain unclear. Here, using human lung tissue that represents different stages of disease and a 33-plex single-cell imaging mass cytometry (IMC), we present a high-resolution, temporo-spatial cell atlas of the regenerating alveolar niche. With unbiased mathematical methods which quantify statistically enriched interactions, CD206himacrophage subtype and an alveolar basal intermediate epithelial cell emerge as the most statistically robust spatial association in the epithelial and immune cell interactome, found across all stages of disease. Spatially resolved receptor–ligand analysis further offers an in silico mechanism by which these macrophages may influence epithelial regeneration. These findings provide a foundational step toward understanding immune–epithelial dynamics in aberrant alveolar regeneration in IPF.
Direct Integration of Functionalized Bridges by One‐Step Superacid‐Catalyzed Reaction to Fabricate Porous Polymers for CO <sub>2</sub> Capture and Separation
Abstract A novel class of ultra‐microporous functionalized porous organic polymers (POPs) was developed starting from glyoxylic acid as a cross‐linker and triflic acid as a catalyst on polyaromatic monomers, generating in situ methine bridges with carboxylic acids. This one‐pot synthetic method generated functionalized POPs with high connectivity per each aromatic group and a high density of aliphatic carboxylic acids decorating the pore walls. Remarkably, the functional groups were transformed into esters, Na‐ and Li‐carboxylates by post‐synthetic modification with high yields, generating polyionic porous polymers. These porous polymers displayed excellent CO 2 adsorption at 298 K and isosteric heat of adsorption with values as high as 50 kJ mol −1 for the Na‐containing POP endowed with numerous ionic charges, as estimated by direct measurements with microcalorimetry coupled to CO 2 adsorption isotherms. Dynamic breakthrough experiments on self‐supporting monolithic composites demonstrated high selectivity for CO 2 adsorption over N 2 up to 500 for diluted streams and 340 under relevant conditions for carbon capture from flue gases (0.15 CO 2 partial pressure).
Firefly algorithm with multiple learning ability based on gender difference
Trifunctional local-range order oxygen structure enhanced strength-ductility and fatigue resistance in large-scale metastable titanium alloy
Comparable efficacy of generic and original alginate for symptom control in PPI-refractory GERD
Abstract Gastroesophageal reflux disease (GERD) is a prevalent global condition, affecting 18.1–27.8% of North Americans and 6.3–18.3% of the Thai population. While proton pump inhibitors (PPIs) are the first-line treatment, only about one-third of patients achieve adequate symptom control. Alginate-based medications in combination with PPIs have shown promise, but the comparative effectiveness of generic versus original alginates remains unexplored. To compare the effectiveness of generic alginate (ONE GERD) versus original alginate (Gaviscon Dual Action Suspension) in combination with PPIs for treating GERD symptoms in patients who failed standard PPI therapy.This multicenter prospective randomized controlled non-inferiority trial included 48 patients who failed standard-dose PPI treatment. Patients were randomized to receive either generic or original alginate four times daily for 28 days. Treatment response was evaluated using the Reflux Disease Questionnaire (RDQ) at days 7 and 28. At day 7, both groups showed identical response rates of 45.83%. By day 28, response rates increased to 54.17% for generic alginate and 70.83% for original alginate (p = 0.23). Total RDQ scores and symptom-free rates showed no significant differences between groups at both time points. Adverse event rates were comparable (16.67% vs. 8.33%, p = 0.66). Analysis of specific symptoms (heartburn, chest pain, and regurgitation) revealed similar improvements in both groups throughout the study period. This study provides evidence supporting the therapeutic equivalence of the generic alginate (ONE GERD) to the original formulation (Gaviscon Dual Action Suspension) in treating symptoms for patients with GERD who have failed PPI therapy. Crucially, the comparable efficacy and safety, coupled with the inherent lower cost of generic medications, suggest significant economic benefits and the potential for wider patient access to effective GERD management. This makes generic alginate a viable and attractive alternative in clinical practice, particularly in resource-limited settings or for patients facing financial constraints, thereby contributing to more equitable healthcare solutions without compromising therapeutic outcomes.