Browse Articles

Assessment of the in vitro antimicrobial activity and fatty acid composition of crocodile oil from Crocodylus siamensis

<i><b>N</b></i>-Oxide-Driven Heme-Activatable Biomolecule Labeling for Visualization of Labile Heme in Living Cells and Mouse Brain

Cryo-EM reveals molecular mechanisms underlying the inhibitory effect of netrin-4 on laminin matrix formation

Incidence and risk factors of new-onset hypertension up to 3 years post SARS-CoV-2 infection

Unveiling Water-Vapor-Promoted Oxidation of Palladium Nanoparticles via Atomic-Scale Transmission Electron Microscopy at Atmospheric Pressure

CSLD5-mediated cell wall remodelling regulates tissue mechanics and shoot meristem growth

Metabolically engineered plant cell cultures as biofactories for the production of high-value carotenoids astaxanthin and canthaxanthin

Abstract Astaxanthin and canthaxanthin are high-value carotenoids with growing demand due to their antioxidant properties and applications in food, cosmetic, and pharmaceutical sectors. However, natural sources are limited and current production methods are often costly or unsustainable. In this study, we developed a plant-based platform for ketocarotenoid biosynthesis using metabolically engineered Nicotiana tabacum BY-2 cell suspension cultures. Specifically, we expressed a marine bacterial crtW gene ( β-carotene ketolase ) alone or in combination with overexpressed plant psy ( phytoene synthase ) and crtI ( phytoene desaturase ) genes. The resulting cell lines displayed visually distinct pigmentation and accumulated different ketocarotenoid profiles based on their genetic modifications. Single-gene transformants expressing crtW produced up to 50 µg g⁻¹ DW of canthaxanthin and 127 µg g⁻¹ DW of astaxanthin. Co-expression of all three genes significantly increased canthaxanthin accumulation to 788 µg g⁻¹ DW. Our results establish suspended undifferentiated plant cells as a scalable and sustainable system for ketocarotenoid production, offering a biological alternative to natural producers and chemical synthesis.

Electronic Modification of a Reduced Mononuclear Nonheme Iron Nitrosyl Complex Leads to HNO Release

Metal-driven anaerobic oxidation of methane and the Sturtian deglaciation

Novel SMA BASED Elmanspiking neural network modelled fuzzy PI controller for speed-torque regulation of PMSM

O-Induced Diatomic Fe–Mo Mimetic Enzyme for Efficient Electrocatalytic Nitrogen Reduction at Universal pH

Grid congestion stymies climate benefit from U.S. vehicle electrification

Interplay of electronic and magnetic phase modulation in a spin-polarised nanomagnet

Daily briefing: Reflections from a survivor of the Hiroshima bombing

Predictions of Steady-State Photo-CIDNP Enhancement by Machine Learning

Cyano group translocation to alkenyl C(sp2)–H site by radical cation catalysis

Investigation of parallel joint density thresholds for granite tunnel failure based on physical model experiments and multiscale monitoring techniques

Isolation of Diamond Spin Chains in a Layered Halide Perovskite Heterostructure

Spin-polarized self-trapped excitons in low-dimensional cesium copper halide

Abstract Spin polarized excitons induced by spin injection from magnetic ion to a single quantum dot, has been considered as a basic unit of quantum information transfer between spin and photon for spin-photonic applications. However, this state-of-the-art technology has only been found with limited coupling strength and weak excitonic emission. Here, we demonstrate a spin-polarized self-trapped exciton naturally formed in the zero-dimensional lattice of cesium copper iodide. Upon excitation, the conversion from Cu+ ion to spin-1/2 Cu2+ ion results in an in-situ self-trapped exciton, which facilitates a local Jahn-Teller distortion and guarantees the strong spin-exciton coupling and near-unity excitonic emission efficiency. Consequently, a giant Zeeman splitting of −53 meV and an effective excitonic g-factor of −93.5 are observed from magneto-photoluminescence. More importantly, this nano-scale coupling can also be driven by an external electric field, which generates electroluminescence with a circular polarization of 44.5% at 4.2 K and 8% at 300 K. The spin-optic properties of this copper compound will stimulate the fabrication of next-generation spin-photonic devices based on self-trapped excitons.

Natural history study of recessive dystrophic epidermolysis bullosa wounds and patient reported outcomes using mobile application home photography