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KH–R3H domain cooperation in RNA recognition by the global RNA-binding protein KhpB

Large-scale online assessment uncovers a distinct Multiple Sclerosis subtype with selective cognitive impairment

Abstract Cognitive impairments in Multiple Sclerosis (MS) are prevalent and disabling yet often unaddressed. Here, we optimised automated online assessment technology for people with MS and used it to characterise their cognitive deficits in greater detail and at a larger population scale than previously possible. The study involved 4526 UK MS Register members over three stages. Stage 1 evaluated 22 online cognitive tasks and established their feasibility. Based on MS discriminability a 12-task battery was selected. Stage 2 validated the resulting battery at scale, while Stage 3 compared it to a standard neuropsychological assessment. Clustering analysis identified a prevalent MS subtype exhibiting significant cognitive deficits with minimal motor impairment. Disability in this group is currently unrecognised and untreated. These findings underscore the importance of cognitive assessment in MS, the feasibility of integrating online tools into patient registries, and the potential of such large-scale data to derive insights into symptom heterogeneity.

Tuning Catalytic Reactivity via Wetting Control through Oxygen Vacancies: Ru Clusters on Anatase TiO₂ and CeO₂ Supports

Design of a P–O–M (M = Mn, Zn) d-pπ Backbonding Electrolyte Additive for 40 Ah Electrolytic Zn–MnO₂ Batteries

Breaking Endosomal Barriers: Thiol-Mediated Uptake Lipid Nanoparticles for Efficient mRNA Vaccine Delivery

Photoactivatable RNA Tags for Subcellular Photolabeling of RNA

Hydrolysis Kinetics at the Air–Water Interface

Moiré Patterns of Two-Dimensional Covalent Organic Framework Single Crystals Created by Superstacking

Molecular Basis for the Activation of <i>Pseudomonas aeruginosa</i> MsbA by Divalent Metals

Observation of Water Complexes of the Sulfur–Nitrogen Compounds HNS and HSN

In Situ 3D Structural Determination of Soft Biomaterials by Computationally Assisted Polarized Raman Spectroscopy

Near Room-Temperature Atomic Layer Deposition of Magnesium Oxide Using Bis-3-(<i>N</i>,<i>N</i>-dimethylamino)propyl Magnesium(II) and Water

Regulating and Deciphering the Selective Synthesis of Metallacages in Microdroplets

An Insight into the Relation of Spin-Polarization and Oxygen Evolution Enhancement with a Monolayer Chiral Covalent Organic Framework Model Catalyst

<i>In Situ</i> Identification of Dynamic Active Sites in the Electrocatalytic Nitrate Reduction Reaction

Crystal Growth Modulation of Tin–Lead Halide Perovskites via Chaotropic Agent

Electronic Configurational Transformation of Network Modifiers in Aluminate Glass above Megabar Pressures

Controlled Molecular Orders in Layered Multiple Porphyrins

Porous Gold Nanoumbrellas with Adjustable Apical Angles for Selective Electrosynthesis of Styrene Epoxide from Styrene

Molecular Engineering of Terminus, Conjugation, and Energetics for Thermally Stable Inverted Perovskite Solar Cells