Browse Articles

Probing stress and magnetism at high pressures with two-dimensional quantum sensors

Thrombus enhancement as a predictor of embolic in acute basilar artery occlusion

Longitudinal liquid biopsy identifies an early predictive biomarker of immune checkpoint blockade response in head and neck squamous cell carcinoma

Abstract Immune checkpoint blockade (ICB) has improved outcomes for patients with head and neck squamous cell carcinoma (HNSCC), but predictive biomarkers remain limited. Here, we use a time-resolved, multi-omic approach in a murine HNSCC model to characterize peripheral immune responses to ICB. Single-cell transcriptomics and T/B cell receptor analyses  reveal early on-treatment expansion of effector memory T and B cell repertoires in responders, preceding tumor regression. These dynamic immune features inform a composite transcriptional signature that accurately predicts ICB response in independent human HNSCC cohorts. LiBIO outperforms existing biomarkers and generalizes to melanoma, non-small cell lung cancer, and breast cancer without retraining. These findings suggest that early treatment-induced changes in circulating immune repertoires reflect the host’s capacity to mount an effective antitumor response. This work provides a framework for leveraging transient peripheral immune dynamics to develop non-invasive, high-fidelity biomarkers for response to immunotherapy across cancer types.

Bioinformatic analyses and validated experiments reveal an aging hallmark gene set and protective miR of coronary artery disease

Hydrocarbothermal flow synthesis of carbon-supported small and dense high-entropy alloy nanoparticles as electrocatalysts

An efficient voltammetric platform integrating ZnS nanowires, reduced graphene oxide sheets, and ferrocene monocarboxylic acid for the sensitive detection of homocysteine

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1

Abstract Metastasis is responsible for most cancer-related deaths. However, only a fraction of circulating cancer cells succeed in forming secondary tumours, indicating that adaptive mechanisms during circulation play a part in dissemination. Here, we report that constriction during microcapillary transit triggers reprogramming of melanoma cells to a tumorigenic cancer stem cell-like state. Using a microfluidic device mimicking physiological flow rates and gradual capillary narrowing, we show that compression through narrow channels causes cell and nuclear deformation, rapid chromatin remodelling and increased calcium signalling via mechanosensor PIEZO1. Within minutes, cells upregulate transcripts associated with metabolic reprogramming and metastatic processes. Over time, this results in the stable adoption of a cancer stem cell-like state. Squeezed cells express elevated melanoma stem cell markers, exhibit increased trans-endothelium invasion and display enhanced tumorigenicity in vitro and in vivo. Pharmacological inhibition of PIEZO1 blocks this transition, while activation with Yoda1 induces the stem cell-like state irrespective of constriction. Deletion of PIEZO1 completely abolishes the constriction-induced phenotype. Together, these findings demonstrate that compressive forces during circulation reprogram circulating cancer cells into tumorigenic, stem cell-like states, primed for extravasation and metastatic colonization.

Emission characteristics of Eu$$^{2+}$$ and Eu$$^{3+}$$ under x-ray and alpha irradiation in Eu-doped CaF$$_2$$ crystals

In situ and remote observations of the ultraviolet footprint of the moon Callisto by the Juno spacecraft

Abstract Jupiter exhibits peculiar multiwavelength auroral emissions resulting from the electromagnetic interactions of Io, Europa, and Ganymede with the magnetospheric plasma flow. Characterizing the faint auroral footprint of the fourth Galilean moon, Callisto, has always been challenging because of its expected weakness and its proximity to Jupiter’s bright main aurora. Here, we report on unusual magnetospheric conditions that led to an equatorward shift of Jupiter’s main auroral oval unveiling the auroral footprints of the four Galilean moons in a single observation. Remote observations by the Juno spacecraft reveal a double-spot structure, characteristic of the footprints of the other three moons, with a maximum ultraviolet brightness of 137 $$\pm$$ ± 15 kR. Concurrent observations within Callisto’s flux tube reveal field-aligned electrons with a characteristic energy of 10 keV, depositing an energy flux of 55 mW.m-2 in Jupiter’s atmosphere. The electron properties are consistent with the triggering of radio emissions with intensities lower than 5 × 10-18 W.m-2.Hz-1.

Enhanced composed fashion image retrieval with a multi-hop reasoning framework

AEBP1 drives fibroblast-mediated T cell dysfunction in tumors

Enhancing direct torque control of doubly fed induction motor in electric vehicle using artificial neural networks

Integrated lithium niobate photonic computing circuit based on efficient and high-speed electro-optic conversion

Inside Front Cover: Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol (Angew. Chem. Int. Ed. 36/2025)

Multi-dimensional model and interactive simulation of intelligent construction based on digital twins

Support-tuned iridium reconstruction with crystalline phase dominating acidic oxygen evolution

Abstract The dynamic reconstruction of oxygen evolution electrocatalysts dictates their performance, yet conventional Ir-based materials face an inherent activity-stability trade-off due to surface amorphization into hydrous IrOx phases accompanied by lattice oxygen mechanisms. Here, we uncover a distinct reconstruction pathway for supported Ir nanoparticles, where a TiOx@Ti substrate drives a bulk phase transition from metallic Ir to crystalline rutile IrO2 during electrocatalysis. Unlike surface-limited amorphization, this support-guided crystallization shifts the reaction mechanism from involving lattice oxygen mechanism to the complete adsorbate evolution mechanism, as confirmed by mechanistic and structural analyses. Consequently, the Ir/TiOx@Ti catalyst achieves both high activity and durability in acidic media, demonstrated in three-electrode systems and proton exchange membrane water electrolyzers. This work redefines support roles in electrocatalyst reconstruction, demonstrating that bulk phase engineering—rather than surface modification—resolves the long-standing efficiency-durability conflict in acidic oxygen evolution.

Umbilical cord-derived exosomes alleviate spinal cord injury by regulating microglial polarization through miR-340-5p-mediated modulation of the JAK/STAT3 signaling pathway

Ultrahigh pressure compaction-resistant thin film crosslinked composite reverse osmosis membranes

Abstract In this study, we present a class of thin-film crosslinked (TFX) composite reverse osmosis (RO) membranes that resist physical compaction at ultrahigh pressures (up to 200 bar). Since RO membranes experience compaction at virtually all pressure ranges, the ability to resist compaction has widespread implications for RO membrane technology. The process described herein involves crosslinking a phase inverted porous polyimide (PI) support membrane followed by interfacial polymerization of a polyamide layer, thereby forming a fully thermoset composite membrane structure. We explore a range of phase inversion membrane formation parameters such as PI concentration, solvent-cosolvent ratios, coagulation bath composition, and crosslinking methods in addition to interfacial polymerization reaction chemistry and conditions. Overall, TFX membranes exhibit significantly less compaction compared to hand-cast and commercial high-pressure RO membranes, experiencing less than 10% decline in water permeance and maintaining salt rejection over 99% for NaCl solutions up to 180,000 mg/L with 200 bar applied pressure.

Correction: Regulator of G protein signaling-1 facilitates ovarian cancer development by modulating NF-kB signal pathway

Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity

Abstract Synaptic connectivity during development is known to require rapid local regulation of axonal organelles. Whether this fundamental and conserved aspect of neuronal cell biology is orchestrated by a dedicated developmental program is unknown. We hypothesized that developmental transcription factors regulate critical parameters of organelle structure and function which contribute to circuit wiring. We combined cell type-specific transcriptomics with a genetic screen to discover such factors. We identified Drosophila CG7101, which we rename mitochondrial integrity regulator of neuronal architecture (Mirana), as a temporal developmental regulator of neuronal mitochondrial quality control genes, including Pink1. Remarkably, a brief developmental downregulation of either Mirana or Pink1 suffices to cause long-lasting changes in mitochondrial morphology and abrogates neuronal connectivity which can be rescued by Pink1 expression. We show that Mirana has functional homology to the mammalian transcription factor TZAP whose loss leads to changes in mitochondrial function and reduced neurotransmitter release in hippocampal neurons. Our findings establish temporal developmental transcriptional regulation of mitochondrial morphology as a prerequisite for the priming and maintenance of activity-dependent synaptic connectivity.