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Amplifying Engineered Bacterial Outer Membrane Vesicle Production Using Functional Peptidoglycan Inhibitors
The impact of almond supplementation on oxidative stress biomarkers: a systematic review and meta-analysis of randomized control trials
Air pollution could be reduced by incentivizing local government officials to control crop burning
Supertough and Multirecyclable Cross-Linked Polyurethane Enabled by Supramolecular Chain Extenders and Noncovalent Cross-Linkers
Deep learning-based phase demodulation for distributed acoustic sensor
Many planets might be born with orbits misaligned from the spin of their stars
Preparation of 1,4-Diamines by Enantio- and Diastereoselective Cu–Josiphos-Catalyzed Reductive Couplings of Azatrienes and Imines: Regiodivergence Enabled by Catalyst Structure and Reagent Tailoring
Systemic immune-inflammation index and serum lactate dehydrogenase predict the prognosis of non-metastatic nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy
Decoding Chirality Transfer Strengths and Structure–Property Relationships in Bismuth-Containing Chiral Hybrid Organic–Inorganic Semiconductors
Formation and sustenance mechanism of bacterial diversity in nutrient-deficient environment of indoor stadium
These tiny flyers levitate on the Sun’s heat alone
Two-in-One Flexible Metal–Organic Framework: One-Step C<sub>2</sub>H<sub>4</sub> Purification via Inverse C<sub>2</sub>H<sub>6</sub>–C<sub>2</sub>H<sub>4</sub> and C<sub>2</sub>H<sub>2</sub>–CO<sub>2</sub> Separations
Sociodemographic factors and biologic therapy exposure impacting health-related quality of life in psoriatic arthritis - findings from a nationwide registry Reuma.pt
Enzyme-Mimicking Copper Single-Atom Catalyst for Selective Oxidation of Methane to Liquid Oxygenates
Efficient workflow scheduling using an improved multi-objective memetic algorithm in cloud-edge-end collaborative framework
Null empathy
Lattice-Nitrogen-Mediated Chemistry Suppresses Hydrogen Evolution for Record Faradaic Efficiency in Ammonia Synthesis
Nationwide study of spondyloarthritis spectrum and disease characteristics in Egypt
Abstract The aim of this study was to describe the array and disease characteristics of spondyloarthritis (SpA) across Egypt. This work included 1401 SpA patients recruited from 15 specialized Egyptian rheumatology centers representing 20 major cities. The demographic and clinical features, as well as the therapeutic data, were recorded. The mean age of the patients was 37.6 ± 11.4 years, disease duration 8.01 ± 6.7 years, and age at onset 29.9 ± 11 years; 148 (10.6%) were juvenile-onset. There were 813 males and 588 females (M: F 1.4:1). 5.7% were diabetic, 6.1% hypertensive, and 19.3% were smokers. The mean BASDAI was 3.98 ± 1.78, and the BASFI was 4.02 ± 1.77. The human leukocytic antigen (HLA-B27) was positive in 19.8%. Biologic therapy was received by 55.5%, followed by methotrexate (36%) ,steroids (10.8%), and sulfasalazine in 10.7%. In males, the age at onset was significantly lower (p = 0.02), while radiographic axSpA, neuropsychiatric and pulmonary manifestations, HLA-B27 positivity, and receiving biologic therapy were significantly higher (p = 0.02, p < 0.0001, p = 0.03, p < 0.0001, and p < 0.0001). In females, cutaneous manifestations and arthritis were significantly more frequent (p < 0.0001 and p < 0.0001). Those with positive HLA-B27 had a significantly higher frequency of AS (73%) (p = 0.003), male gender (66.2%) (p < 0.0001), longer disease duration (p = 0.001), and were receiving a higher frequency of biologic therapy (89%, p < 0.0001). Radiographic axial SpA was most reported from Assuit (15.9%), nr-axSpA from Cairo (24.5%), peripheral arthritis only from Giza (30.7%), and unclassified from Kafr ElSheikh (33.9%) (p = 0.002). The spectrum of SpA in Egypt is inconsistent across the country. Gender, disease subtype, and HLA-B27 seem to play a key role in the phenotypic presentation.