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Long term efficacy of adjuvant chemotherapy in elderly patients with early stage breast cancer assessed through SEER database analysis
Maternal Western-style diet has a persistent effect on offspring gene expression in skeletal muscle of Japanese macaques
Effects of peptides derived from active sites of visfatin on wound healing
Addressing pathological deficiencies in the simulation of complex charged fluids using neural network force fields
Subjective distress mediates the association between olfactory dysfunction duration and depression in post COVID 19 patients
Evaluating miscarriage incidence after COVID-19 vaccination
Abstract COVID-19 infection during pregnancy might be associated with maternal complications. This study aimed to investigate the impact of COVID-19 vaccination on the risk of miscarriage. This cohort study included 26,701 women of reproductive age (15–49) who were vaccinated with different vaccines (Sinopharm, Sputnik V, AZD1222 and CoVIran Barekat) between April 2021 and August 2022 in seven cities in Iran. Among them 459 women were pregnant and included in this analysis. All pregnant women were followed up until the end of their pregnancy. The mean age (standard deviation) of pregnant women was 31.7 (6.8) years. Among them, 50 miscarriage cases occurred. The cumulative incidence of miscarriage was 10.9%; 95% confidence intervals [CI] 8.0–13.8) in total, and 11.0% (5.9–16.1), 9.7% (4.4–14.9), 12.0% (5.9–18.2), and 11.1% (4.2–18.0) for AZD1222, Sputnik V, Sinopharm and Barekat vaccines respectively. Cumulative incidence rates by vaccine brands were not statistically significant (P value = 0.962). The mean (SD) time interval between conception and vaccination was 3.5 (3.8) weeks and it was 7.5 (2.7) weeks for the age of the fetus at miscarriage. In general, the miscarriage rate in women of reproductive age was 4.8 (95% CI 4.1–5.7) per 1000 women. The estimated incidence rates were not higher than expected; therefore, it can be argued that COVID − 19 vaccination with Sputnik V, Sinopharm, Barekat and AZD1222 does not increase the probability of miscarriage and the vaccines are therefore safe in this respect.
Association of dietary minerals and phosphorus to protein ratio with quality of life in Iranian Hemodialysis patients: a cross-sectional study
An analytical model of condensed explosives under slow cook-off conditions
MICP incorporated biopolymer to mitigate wind erosion of sand
Automated ejection fraction and risk stratification in cardiomyopathy patients with diverse LV geometry using 2D echocardiography
Research on the self-lubricating performance of rolling linear guide based on directional porous media
TRBP modulates RLR signaling by inhibiting PKR-mediated antiviral stress granule formation
Colonization with antibiotic resistant bacteria in communities and hospitals across six countries, including Bangladesh, Botswana, Chile, Guatemala, India, and Kenya
Abstract The recognized burden of antimicrobial resistance (AR) is greatest in low- and middle-income countries (LMICs), but limitations in surveillance preclude accurate estimates of AR. We aimed to evaluate colonization in communities and hospitals across six LMICs for two clinically-important pathogens: extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE) and carbapenem-resistant Enterobacterales (CRE). Participants in hospitals and communities provided rectal swabs or stool samples for ESCrE and CRE identification. Isolates recovered from selective agars underwent confirmatory identification and antibiotic susceptibility testing (AST) using Vitek® 2, MALDI-TOF, and/or disc diffusion testing. ESCrE and CRE were defined based on established breakpoints of phenotypic resistance to third-generation cephalosporins and carbapenems, respectively, to calculate prevalence of colonization. Community prevalence estimates were weighted to account for sampling design differences. A total of 10,139 participants across the 6 countries provided samples; 63% were females with a median age of 35 years (range: 0–99). Colonization with ESCrE in hospitals was high in all sites (range 34–84%). In communities, ESCrE colonization ranged from 22 to 77%. Prevalence of CRE colonization in hospitals ranged from 7 to 36% and in communities ranged from < 1 to 14%. These findings reveal a high burden of AR colonization in LMICs in both communities and hospitals. Cost-effective strategies to reduce AR colonization burden are needed in LMICs.
The evolving immuno-angiogenic paradigm in NSCLC: lessons from ivonescimab
Identification of ecdysteroids and ecdysteroidogenic genes in dragonflies and damselflies
Abstract Ecdysteroids are critical in regulating biological processes such as ecdysis, metamorphosis, embryogenesis, and reproduction in insects. Nevertheless, the ecdysteroid repertoire and expression patterns of their synthesis genes in Odonata (dragonflies and damselflies), which belong to the most-ancestral winged insect group, have remained elusive. In this study, we examined the ecdysteroid profile of eight Odonata species and the ecdysteroid fluctuation during metamorphosis in the damselfly Ischnura senegalensis (Zygoptera, Coenagionidae) and the dragonfly Pseudothemis zonata (Anisoptera, Libellulidae). We found that ecdysone and 20-hydroxyecdysone (20E) titers corresponded to the progression of ecdysis in the penultimate nymphal instar and metamorphosis in the final nymphal instar, whereas 7-dehydrocholesterol was consistently present in the hemolymph of all the examined species and developmental stages. Considering that a higher amount of 20E was detected than ecdysone, 20E is important for inducing ecdysis and metamorphosis in Odonata, like other insects. We also confirmed that the majority of ecdysteroidogenic genes were conserved in Odonata, and their stage- and region-specific expression patterns were examined in I. senegalensis and P. zonata. Unexpectedly, most ecdysteroidogenic genes were expressed in a variety of tissues. Our study provides insights into the evolution and diversification of the ecdysteroidogenic pathway among insects.
Renal hyperfiltration as risk factor of major adverse cardiovascular events in patients with acute myocardial infarction
Optimizing Aedes albopictus rearing: effects of insect- and bacteria-based larval diets on immature and adult performance
Characterization of collagen profile in peritoneal metastases of colorectal cancer
Abstract The tumor microenvironment (TME) plays a critical role in cancer progression and response to treatment. In colorectal cancer (CRC), a collagen-rich extracellular matrix (ECM) is a well-established feature of primary tumors and liver metastases. However, the composition of the ECM in peritoneal metastases remains poorly characterized. In this descriptive study, we analyzed the histological distribution of four major collagen types (I, II, III, and IV) in peritoneal metastases from 39 CRC patients using immunohistochemical techniques. Type III fibrillar collagen was predominant, showing moderate to high expression in 80 percent of cases, followed by type IV collagen in 56 percent. Type I collagen demonstrated low intensity in 64 percent of cases. Notably, type II collagen, typically restricted to cartilaginous tissues, was also detected within the tumor stroma, an unexpected finding given its usual absence in this histological contex. These results highlight the unique collagen-rich stroma in CRC peritoneal metastases, dominated by types III and IV collagen, and identify type II collagen as a novel component. This study provides new insight into the stromal architecture of CRC peritoneal metastases and may serve as a foundation for future research on collagen-targeted therapeutic strategies.