Browse Articles

Integrated microscopic, HPTLC, and HRM analyses for differentiating Centella asiatica (L.) Urb., Bacopa monnieri (L.) Wettst, and Hydrocotyle umbellata L.

Experimental and numerical investigation of endwall flow control through air injection in a contra rotating fan

Climate, diet, and nutrition drive gut microbiome variation in a fruit-specialist primate

Polyphasic and phylogenomic reevaluation of Zhongshania and Marortus with the description of Zhongshania aquatica sp. nov.

Randomized clinical trial on the effects of early cognitive interventions for children with acquired brain injury

Value of integrated PET-IVIM MRI in predicting Ki-67 expression in newly diagnosed prostate cancer

Abstract Accurate assessment of Ki-67 expression in patients with prostate cancer (PC) is paramount. Therefore, this study aimed to assess the value of integrated Gallium-68(68Ga)-prostate-Specific membrane antigen-11 (PSMA) Positron Emission Tomography/Intravoxel Incoherent Motion Magnetic Resonance Imaging (PET/IVIM MRI) in predicting Ki-67 expression in newly diagnosed PC. A retrospective analysis was conducted on 37 newly diagnosed PC patients who underwent 68Ga-PSMA-11 PET/MR for staging. Maximum Standardized Uptake Value( SUVmax) and IVIM parameters of lesions were quantified. Patients were stratified into low-risk (Ki-67 < 5%) and high-risk groups (Ki-67 > 5%). SUVmax and IVIM parameters were compared between the two groups. Of the 37 patients, 29 were categorized as high risk, while 8 were classified as low risk. The high-risk group exhibited significantly higher SUVmax (21.4 ± 11.3 vs. 11.2 ± 8.5, P = 0.025) and lower Standard apparent diffusion coefficient (ADC) (0.0011 ± 0.00023 vs. 0.0014 ± 0.00039, P = 0.005) compared to the low-risk group. Receiver operating characteristic (ROC) analysis determined optimal cut-off values for predicting high-risk patients as 7.64 for SUVmax (sensitivity: 96.6%, specificity: 59.1%) and 0.0013 for standard ADC (sensitivity: 89.7%, specificity: 52.3%). Integrated assessment of SUVmax and standard ADC using 68Ga-PSMA-11 PET-IVIM MRI may aid in predicting Ki-67 expression, with optimal thresholds of 7.67 for SUVmax and 0.0013 for standard ADC. These findings offer novel insights into evaluating the biological behavior of prostate cancer tumors in patients undergoing PET/MR imaging.

Factors influencing the real-world effectiveness of benralizumab in uncontrolled asthma

Promising results with zongertinib in advanced-stage HER2-mutant NSCLC

Spatial temporal trends and inequality in agricultural eco-efficiency under carbon constraints in China

Predictive value of asprosin combined with LAP for metabolic dysfunction associated steatotic liver disease in the physical examination population

A novel Compound-Pareto model with applications and reliability peaks above a random threshold value at risk analysis

LASSO regression-based nomogram for distinguishing nontuberculous mycobacterial pulmonary disease from pulmonary tuberculosis: a clinical risk prediction model

New equations to estimate 24-h urinary creatinine excretion

Self-perceived health control status and influencing factors in young and middle-aged peritoneal dialysis patients: a cross-sectional survey

Assessments of Anopheles arabiensis behaviour around bed nets using partial adhesive treatments

NT-proCNP as a new biomarker of pulmonary hypertension in patients with COPD

Next-generation KRAS-G12C inhibitor D3S-001 shows promise

Multi-band frequency selective metasurface based filter for WLAN and X-band EMI shielding applications

L-shape association between serum chloride and 365-day mortality in critically ill patients with sepsis based on the MIMIC-IV database

Influence of gender, limb dominance, training experience, and loading conditions on arch characteristics in badminton players