Browse Articles
Discover research articles across all indexed journals
Warming and salinity changes of the upper ocean Caribbean through-flow since 1960
Experimental and theoretical study on flexural performance of concrete beams strengthened by unbonded prestressed ultra-high performance concrete layer
Understanding the effect of stay-at-home orders on psychological distress during the COVID-19 pandemic: Evidence from a longitudinal study in Australia
The extraordinary public policy response to COVID-19 in Australia saw extended lockdowns in some Australian states and territories, some of the longest in the world. This paper seeks to understand the effect these periods of lockdown had on the mental health of those living through them. Using a staggered difference-in-differences design we study two different periods — one in 2020, one in 2021. During this time there were some jurisdictions (Victoria, New South Wales and in the second period the Australian Capital Territory) experiencing extended lockdowns while the rest of the country was largely living life as normal with no or low local transmission of the virus. While there seems to have been an effect in this first period, we do not find a statistically measurable effect in 2021 as even though distress rose during the lockdown period, it rose similarly among those jurisdictions out of lockdown as well. We speculate this may be because of adaptation to stress, growing cases in control jurisdictions, or the vaccine roll-out providing a concrete endpoint for lockdowns.
Factors associated with pressure ulcers among middle-old and oldest-old inpatients in an acute care hospital
Optimization of air conditioning mechanical ventilation using simulated annealing for enhanced energy efficiency and cost reduction
Unravelling the relationship between extreme precipitation duration and wet-day frequency at global scale
Impacts of carbon nanotubes and nano-graphene oxide on fatigue cracking in HMA exposed to runoff with varying acidity
Effects of alkali stress on antioxidant capacity, lipid metabolism, apoptosis and autophagy of Eriocheir sinensis
Abstract This study investigates the effects of alkali toxicity on Chinese mitten crab (Eriocheir sinensis) exposed to 17.5 mmol/L alkalinity for four weeks. Alkali toxicity resulted in significant physiological responses, notably reducing survival rates. There was a marked increase in MDA content and a decrease in SOD, CAT, and T-AOC levels in the hemolymph. Additionally, there was an elevation of ROS levels in the gills and hepatopancreas, along with Keap1 expression, leading to tissue oxidative damage. Alkalinity exposure induced apoptosis, significantly increasing the mRNA expression of Bax, caspase3, P53, and a notable rise in TUNEL-positive cells. Long-term alkali exposure also reduced hepatopancreas lipid accumulation by promoting CPT1 while inhibiting SREBP, ACC, and CAAT expression. Furthermore, autophagy was considerably influenced by alkali stress, as evidenced by the upregulation of mRNA expression of ATG5, ATG7, LC3a, Beclin1, as well as the protein expression of Beclin1 and parkin. Overall, the findings indicate that alkalinity exposure triggers oxidative stress, lipid metabolic disorder, apoptosis, and autophagy in E. sinensis, providing insights into how E. sinensis adapts to saline-alkali environments and sustainable development in saline-alkali waters.