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Congruence between noise and plasticity in protein expression
Abstract Gene expression responds to various types of perturbations, such as mutations, environmental changes, and stochastic molecular noises. These different types of variability are often interdependent, where genes sensitive to one perturbation tend to be sensitive to others. However, the relationship between plasticity (variability in response to environmental changes) and noise (variability among cells under the same conditions) in gene expression remains debatable. Previous studies predicted a positive correlation between plasticity and noise in nonessential genes, but these were often measured at different levels: plasticity at the mRNA level and noise at the protein level. This methodological discrepancy complicates the understanding of their relationship. We addressed this by measuring protein expression in Escherichia coli , quantifying both plasticity and noise from the same dataset using flow cytometry. Essential genes exhibited lower noise and plasticity than nonessential genes. Nonessential genes showed a positive correlation between noise and plasticity, while essential genes did not. This study provides empirical evidence of essentiality-dependent coupling between noise and plasticity in protein expression, highlighting the organization of different types of variabilities.
The influence of biological preparations on soil parameters and aclonifen removal
Effectiveness of machine learning models in diagnosis of heart disease: a comparative study
Comparison of the outcomes of trabeculectomy and Ab interno trabeculotomy on corneal biomechanics
Recurrent academic path recommendation model for engineering students using MBTI indicators and optimization enabled recurrent neural network
Enhancing stroke risk prediction through class balancing and data augmentation with CBDA-ResNet50
Quality prediction method for automotive body resistance spot welding based on digital twin technology
Multiregional representations of intertemporal decision making in human single neurons
Abstract Understanding the neural mechanisms underlying delay discounting—the tendency to prefer smaller, immediate rewards over larger, delayed rewards—is critical for elucidating the etiology of impulsive decision-making, a hallmark of several psychiatric conditions including substance use and impulse control disorders. Here, we investigate single-neuron activity in the orbitofrontal cortex (OFC), hippocampus, and amygdala of nine human participants performing a delay discounting task. Intracranial recordings yielded a total of 193 single units (50 OFC, 68 amygdala, and 75 hippocampus) and reveal distinct neural correlates of decision-making, including representations of choice preferences and decision difficulty across all three regions. Analyses demonstrate preferential encoding of choice in the OFC. Additionally, we report that hippocampal activity reflects interindividual differences in discounting rates, with stronger representation observed in participants with slower temporal discounting. These findings provide novel insights into the multiregional neural computations underlying intertemporal decision-making and their relationship to impulsive behaviors.
Structure-based design of an antibacterial peptide from the Myotoxin II sequence, evaluating its effectiveness against Gram-negative bacteria and its safety
Protective capacity of Rutin against oxidative damage induced by saline stress in the roots of the model organism Allium cepa
Advanced hydrogel optical fiber sensors with triple-readout for real-time pH sensing
Sub-chilling methods for Atlantic salmon with 7 days in refrigerated seawater and subsequent sub-chilled storage
Abstract This study evaluated the sub-chilling of whole gutted Atlantic salmon in refrigerated seawater (RSW) maintained at -1 °C for 7 days, compared to traditional ice storage at 0 °C and RSW storage at -1 °C for 4 days followed by 3 days without ice. After filleting, portioning, and modified atmosphere packaging, the initial RSW-stored fish were continuously stored at -1 °C, while the initial ice-stored fish were stored at refrigerated temperatures at 4 °C. The 7-day RSW storage resulted in a significant weight gain, higher water-holding capacity (WHC), and increased water and salt content. Ice-stored fish had higher calpain activity. After packaging, drip loss was highest for the 4-day RSW-stored fish. The 7-day RSW-stored fish demonstrated consistently better WHC and water content. The CO2 levels decreased, while O2 levels increased more rapidly within the package for the RSW-stored fish. There was also a significant extension in the microbiological and sensory shelf life for the RSW-stored fish. Photobacterium was the dominant bacterium in all storage methods. This study highlights the potential to extend salmon shelf life with sub-chilling, significantly reducing ice usage.
CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts
The association between fodmaps intake and psychological disorders in a large sample of Iranian adults
A bi-decision model for electric vehicle dispatch and battery swapping station charging schedule problem
RareInsight simplifies the communication of genetic results for rare disease patients
Unveiling the role of localized polaronic mid-gap states in enhanced carrier transfer in TiO2/BiVO4 heterojunctions under visible light irradiation
Abstract TiO2/BiVO4 heterojunctions are considered to be one of the most promising materials for photocatalysts due to their extended carrier lifetime, high visible light response, and good stability. However, while Type-II TiO2/BiVO4 heterojunctions are well-studied, the fundamental mechanism behind the Type-I configurations remains unclear, particularly regarding their unexpected high photocatalytic activity despite theoretically unfavorable band alignment. Herein, we reveal that localized polaronic mid-gap states (SP states) can mediate efficient charge transfer and recombination in TiO2/BiVO4 using time-resolved photoluminescence (PL) spectroscopy and transient absorption spectroscopy (TAS), providing direct experimental evidence of this mechanism. The existence of SP states enables exceptional methyl orange degradation efficiency (nearly 100% in 1 h under visible light) despite the theoretically unfavorable Type-I alignment. This work redefines the potential of Type-I systems for visible-light photocatalysis by demonstrating how polaron engineering overcomes the limitations of traditional band structures, advancing their applications in solar utilization.