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Author Correction: PPP2R1A mutations portend improved survival after cancer immunotherapy
Symmetry-broken MoS2 nanotubes through sequential sulfurization of MoO2 nanowires
Complex carbohydrate utilization by gut bacteria modulates host food consumption
Abstract The gut microbiota interacts with dietary nutrients and can modify host feeding behavior, but underlying mechanisms remain poorly understood. Gut bacteria digest complex carbohydrates that the host cannot digest and liberate metabolites that serve as energy sources and signaling molecules. Here, we use a gnotobiotic mouse model to examine how gut bacterial fructose polysaccharide metabolism influences host intake of diets containing these carbohydrates. Two Bacteroides species ferment fructans with different glycosidic linkages: B. thetaiotaomicron ferments levan with β2-6 linkages, whereas B. ovatus ferments inulin with β2-1 linkages. We find that mice eat relatively more diet containing the carbohydrate that their gut bacteria cannot ferment compared to the fermentable ones: mice colonized with B. thetaiotaomicron consume more inulin diet, while mice colonized with B. ovatus consume more levan diet. Knockout of bacterial fructan utilization genes attenuates this difference, whereas swapping the fermentation ability of B. thetaiotaomicron to inulin confers increased consumption of levan diet. Bacterial fructan fermentation and host feeding behavior are associated with neuronal activation in the arcuate nucleus of the hypothalamus. These results reveal that bacteria nutrient metabolism modulates host food consumption through sensing of differential energy extraction, which contributes to our understanding of determinants of food choice.
Cerebral Embolic Protection during TAVI
Publisher Correction: In situ light-field imaging of octopus locomotion reveals simplified control
Concurrent temporal patterning of neural stem cells in the fly visual system
Transformative Research in Cystic Fibrosis
Robot-assisted mapping of chemical reaction hyperspaces and networks
Maintaining ecological stability for sustainable economic yields of multispecies fisheries in complex food webs
Abstract Fish stocks are increasingly overexploited due to the growing global demand for seafood. As these species are embedded in complex food webs, traditional single-species management plans should be replaced by models that integrate multi-species fisheries with economic market feedbacks into complex food webs to promote sustainable resource use. Here, we develop such a dynamic model involving three open-access fisheries in a complex food web. Systematically comparing six fishing scenarios, we find that targeting low or high trophic levels risks reducing basal biomass or triggering trophic cascades that undermine first ecological stability (food web biomass and persistence) and then sustainability of economic returns (total sustainable catch and revenue). High sustainable economic returns combined with low negative ecological impacts occur when similar mid-trophic level species are caught in multispecies fisheries. We conclude that complex systems analysis can help design ecosystem-based management strategies to achieve a sustainable food supply for the world.
Case 27-2025: A 53-Year-Old Man with Embolic Stroke and Left Ventricular Apical Aneurysm
Volcanic crisis reveals coupled magma system at Santorini and Kolumbo
Abstract Volcanic crises, driven by renewed magma inflow and migration, result in surface deformation and seismicity that can provide unique insights into the structure of volcanic systems and magmatic processes. Although the highly explosive volcanoes of Santorini and Kolumbo 1,2 in the Greek Aegean Sea are just 7 km apart, their potentially coupled deep magmatic feeding systems are only poorly understood 3,4 . The 2025 volcano–tectonic crisis of Santorini simultaneously affected both volcanic centres, providing insights into a complex, multistorage feeder system. Here we integrate onshore and marine seismological data with geodetic measurements to reconstruct magma migration before and during the crisis. Gradual inflation in the Santorini caldera, beginning in mid-2024, preceded the January 2025 intrusion of a magma-filled dike sourced from a mid-crustal reservoir beneath Kolumbo, indicating a link between the two volcanoes. Joint inversion of ground and satellite-based deformation data indicates that approximately 0.31 km 3 of magma intruded as an approximately 13-km-long dike, reactivating principal regional faults and arresting 3–5 km below the seafloor. The 2024–2025 resurgence of magmatic activity beneath both volcanic centres and their apparent coupling provides insights into the dynamic interplay of magma storage, transport and reservoir failure beneath neighbouring volcanoes.
Oncogenic driver mutations underlie the spatial tumour immune landscape of non-small cell lung cancer
Insulator defect detection in severe weather using improved YOLOv8
Insulators, as a vital component of the power system, encounter issues such as misdetection, leakage, and low detection accuracy in inclement weather. To address this problem, this paper proposes a YOLOv8-based insulator defect detection algorithm, YOLOv8-SSF. Firstly, SimAM (parameter-free attention mechanism) is included in the algorithm’s backbone network, which improves the ability to focus on critical features while maintaining a lightweight model. Secondly, the SPDConv layer is added to enhance the algorithm’s feature extraction capability for small-size defective targets. Furthermore, the Focal_EIOU loss function, which balances high- and low-quality anchors to increase detection and localization accuracy, replaces the CIOU loss function. According to experimental results, the enhanced algorithm reduces the rate of misdetection and omission of defects on transmission conductors, accomplishes a comprehensive simultaneous improvement, and achieves 87.2% mean average accuracy (mAP@0.5) on the dataset.
Art within Evidence — Balancing Anticoagulant Duration in VTE Care
Light-induced fine-tuning of optical cavities for organic optoelectronic devices
Abstract Precise structural control is essential for high-performance semiconductors. In organic electronics, traditional methods for tuning the dimensions of device structures often rely on cumbersome, limited-resolution processes such as shadow mask patterning, printing, or viscosity tuning. Here, we report ultraviolet (UV) irradiation in ambient conditions as a transformative approach for tuning structural parameters of organic small molecule hole transport layers (HTLs) in vertical and lateral directions. The method preserves HTL conductivity while facilitating uniform thickness reduction through synergistic photo-induced oligomerization and photo-oxidative layer shrinking. Controlled thinning applies to various organic materials. In cavity architectures, UV-treated organic photodetectors show narrowband detection from 900 to 1200 nm with a full width at half maximum down to 25 nm, and UV-treated organic light-emitting diodes exhibit 75 nm peak tunability. Moreover, this strategy permits micrometer-scale lateral patterning of HTLs. Our work opens new opportunities for precise and practical engineering for organic electronic devices.
Effect of egg irradiation on development and sterility of wild-type and Wolbachia trans-infected Aedes aegypti mosquito vectors
Sterile Insect Technique (SIT), Incompatible Insect Technique (IIT) or a combination of the two has become alternative promising vector control approaches. In order to apply these approaches, the targeted mosquitoes need to be sterilized and released. So far, the irradiation of mosquitoes has been conducted at the pupae or adult stages. In this study, we investigated the possibility of applying X-ray irradiation at the egg stage and also assessed the effect on the development and sterility of both wild-type and Wolbachia trans-infected Aedes aegypti mosquito vectors. The eggs of both wild-type and Wolbachia trans-infected lines were irradiated using X-ray at the doses of 1, 3, 5 and 7 Gy. Development of immature stages was observed. For wild-type Ae. aegypti, X-ray irradiation at the doses from 3 Gy decreased the development of the first-instar larvae and increased the development of the third-instar larvae but there was no effect on pupae. For Wolbachia trans-infected ones, a irradiation dose as low as 1 Gy could increase the development of the forth-instar larvae while an irradiation dose of 7 Gy induced significantly high mortality to the pupae (p < 0.05). To assess sterility, males and females that emerged from irradiated eggs were mated with the non-irradiated ones. Our results showed that an irradiation dose of 7 Gy significantly caused more than 90% sterility in both wild-type males and females (p < 0.05). However, this irradiation dose could be reduced to 5 Gy to sterilize both males and females infected with Wolbachia. Our findings revealed, for the first time, that applying a low-dose X-ray irradiation at the egg stage could sterilize both wild-type and Wolbachia trans-infected Ae. aegypti when they become adults. Egg irradiation could make the implementation of SIT, IIT or combined SIT/IIT for vector control much more feasible as the sterile eggs are easier to distribute and operate when compared to other developmental stages of mosquitoes.
Early Tirofiban Infusion after Intravenous Thrombolysis for Stroke
Disease-linked regulatory DNA variants and homeostatic transcription factors in epidermis
Abstract Identifying noncoding single nucleotide variants (SNVs) in regulatory DNA linked to polygenic disease risk, the transcription factors (TFs) they bind, and the genes they dysregulate is a goal in polygenic disease research. Here, we use massively parallel reporter analysis of 3451 SNVs linked to risk for polygenic skin diseases with disrupted epidermal homeostasis to identify 355 differentially active SNVs (daSNVs). daSNV target gene analysis, combined with daSNV editing, underscored dysregulated epidermal differentiation as a shared pathomechanism. CRISPR knockout screens of 1772 human TFs revealed 123 TFs essential for epidermal homeostasis, highlighting ZNF217 and CXXC1. Population sampling CUT&RUN of 27 homeostatic TFs identified allele-specific DNA binding (ASB) differences at daSNVs enriched near epidermal homeostasis and monogenic skin disease genes, with notable representation of SP/KLF and AP-1/2 TFs. High TF-occupancy promoters were “buffered” against ASB. This resource implicates dysregulated binding of specific homeostatic TF families in risk for diverse polygenic skin diseases.
Minimising the impact of infectious outbreaks on resident quality of life: A qualitative proof of concept study using the Adult Social Care Outcomes Toolkit (ASCOT)
Introduction Infection control measures (ICMs) used to mitigate the effects of infectious outbreaks in care homes impact on resident quality of life (QoL). This qualitative proof-of-concept study explored whether the Adult Social Care Outcomes Toolkit (ASCOT) could feasibly support care home staff in recognising and minimising these impacts. Methods There were two phases involving online interviews with six care home managers/deputies from five homes who had managed notifiable outbreak(s) in the previous six months in two regions of England. Phase 1, using an incident analysis approach, explored the impact of outbreaks and ICMs on resident QoL, mapping data to the eight ASCOT domains. Phase 2 assessed the usefulness of using ASCOT to identify, monitor and minimise impacts on resident QoL during infectious outbreaks. Follow-up interviews were conducted with four care homes from phase 1 and six healthcare professionals with ICM responsibilities. Online interviews were analysed using framework analysis. Findings Phase 1: three types of outbreaks (COVID-19, norovirus, chest infections) were discussed. All were managed using standard ICMs: isolation, increased cleaning, and staff wearing personal protection equipment. The impacts of these measures on resident QoL were described. Phase 2: two overarching themes identified: (i) ICMs as a personal cost for the greater good and (ii) the potential of ASCOT in minimising impacts of infectious outbreaks on resident QoL as a tool to support care planning and mitigating impacts. Conclusion ASCOT can support planning to mitigate the effects of ICMs for infectious outbreaks on resident QoL.