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Alzheimer’s trial results lend momentum to drugs targeting tau
First drug to lower the protein and slow cognitive decline created buzz despite puzzling data
Contagious fish cancer overruns New England lake
Genetic studies reveal rare example of identical transmissible tumors
Publisher Correction: A 98-qubit trapped-ion quantum computer with all-to-all connectivity
Prominent Salk Institute biologist to resign following sexual misconduct investigation
Staffers complain that Salk allowed circadian rhythms researcher Satchidananda Panda to depart quietly, while the allegations and findings remain under wraps
A 3D genome atlas of human tonsil and the role of loop extrusion in B cell somatic hypermutation
B cell maturation within the germinal center tissue microenvironment involves immunoglobulin gene diversification by somatic hypermutation (SHM). How three-dimensional (3D) genome architecture influences SHM is not fully understood. We leveraged sequencing-based and image-based 3D genomics and transcriptomics to map single-cell 3D genome organization and gene expression across cell types and states in human tonsils and in B cell lymphoma cell lines. These analyses revealed trajectories of compartment, looping, and nuclear position changes during the B cell immune response and activation of SHM. Targeted protein degradation of cohesin component RAD21 revealed its contribution to enabling SHM. Our results provide a single-cell 3D genome atlas of human tonsil cells and outline the links between the chromatin loop extrusion machinery and SHM.