Browse Articles

Metabolites as agents and targets for cancer immunotherapy 

Nature Reviews Drug Discovery Marcel P. Trefny, Guido Kroemer, Laurence Zitvogel et al. Oct 01, 2025 DOI: 10.1038/s41573-025-01227-z

Inhibitory effects of β-galactoside α2,6-sialyltransferase 1 on the Hippo pathway in breast cancer cells

Journal of Biological Chemistry Qinglei Hang, Wenqian Li, Jingya Guo et al. Oct 01, 2025 DOI: 10.1016/j.jbc.2025.110266

One-Electron Boron–Carbon Triel Bonding

Journal of the American Chemical Society Paula Castro Castro, Wei-Chun Liu, François P. Gabbaï Oct 01, 2025 DOI: 10.1021/jacs.5c13589

The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations

Journal of Biological Chemistry Birte Hagemeier, Kamilla Ripkens, Nina Schulze et al. Oct 01, 2025 DOI: 10.1016/j.jbc.2025.110729

<i>d</i>⁰ Cation-Based Spinel-Type Sulfide Semiconductors with Color-Tunable Direct-Gap and Ambipolar Dopability

Journal of the American Chemical Society Kota Hanzawa, Takayuki Nagai, Ryoga Nagasawa et al. Oct 01, 2025 DOI: 10.1021/jacs.5c12816

Mannose trimming is the dominant signal for the release of misfolded glycoproteins from ER quality control

Journal of Biological Chemistry Yun-Ji Shin, Ulrike Vavra, Daniel Maresch et al. Oct 01, 2025 DOI: 10.1016/j.jbc.2025.110649

Manipulating the Coordination Environment of Cu Single Atoms via Regulating ZrO₂ Support Crystal Phases for Enhanced CO₂ Electroreduction

Journal of the American Chemical Society Zhuojun Yang, Jiaqi Zhang, Xin Tan et al. Oct 01, 2025 DOI: 10.1021/jacs.5c13661

Mechanism of inhibition of acid-mediated transthyretin aggregation by designed peptides

Journal of Biological Chemistry Xun Sun, Rose Pedretti, H. Jane Dyson et al. Oct 01, 2025 DOI: 10.1016/j.jbc.2025.110594

One-Dimensional Hybrid Metal Halide with Polymer-like Flexible Inorganic Chains and Glass-Forming Ability

Journal of the American Chemical Society Yuchen Zhu, Da Liu, Xinyuan Sui et al. Oct 01, 2025 DOI: 10.1021/jacs.5c11135

Biochemical characterization of a flavodiiron protein from bird parasite Histomonas meleagridis: superoxide as a reaction intermediate

Journal of Biological Chemistry Subrata Munan, Belem Yoval-Sánchez, Canglin Yao et al. Oct 01, 2025 DOI: 10.1016/j.jbc.2025.110685

Trotline-Inspired Mesoporous Carriers for Prolonged Gastrointestinal Retention

Journal of the American Chemical Society Enyun Xing, Yan Yu, Kui Yan et al. Oct 01, 2025 DOI: 10.1021/jacs.5c08856

Branched DNA processing by a thermostable CAS-Cas4 from Thermococcus onnurineus: Expanding biochemical landscape of nuclease activity

Journal of Biological Chemistry Muskan Jain, Asish Kumar Pattnayak, Sakshi Aggarwal et al. Oct 01, 2025 DOI: 10.1016/j.jbc.2025.110701

Fused Octapyrrolyl Cyclooctatetraene with Large NIR-II Faraday Rotation

Journal of the American Chemical Society Daniel J. Martinez, Molly C. Warndorf, Avisek Dutta et al. Oct 01, 2025 DOI: 10.1021/jacs.5c12451

Activity-based probes and chemical proteomics uncover the biological impact of targeting HMG-CoA Synthase 1 in the mevalonate pathway

Journal of Biological Chemistry Sang Ah Yi, Liang Sun, Yi Rao et al. Oct 01, 2025 DOI: 10.1016/j.jbc.2025.110660

Inverse Hydrocarbon Recognition via Nitro Group–Programmed Soft Porous Crystal for One-Step C₃H₆ Purification

Journal of the American Chemical Society Jingmeng Wan, Jia-jia Zheng, Ling Huang et al. Oct 01, 2025 DOI: 10.1021/jacs.5c10706

The bacterial tRNA-modifying enzyme tRNAIle lysidine synthetase is genetically conserved but catalytically variable

Journal of Biological Chemistry Marc J. Muraski, Ferdiemar C. Guinto, Emil M. Nilsson et al. Oct 01, 2025 DOI: 10.1016/j.jbc.2025.110688

Iodonitrene-Mediated Nitrogen Transfer to Alkenes for the Direct Synthesis of NH-Aziridines

Journal of the American Chemical Society Yuri Gelato, Laura Marraffa, Francesco Pasca et al. Oct 01, 2025 DOI: 10.1021/jacs.5c10372

Features of autism can affect age of diagnosis — and so can genes

Nature Heidi Ledford Oct 01, 2025 DOI: 10.1038/d41586-025-03180-8

A Pseudomonas aeruginosa endolytic muramidase targets cell-wall peptidoglycan in bacterial competition

Journal of Biological Chemistry Tietao Wang, Lin Zhang, Mijoon Lee et al. Oct 01, 2025 DOI: 10.1016/j.jbc.2025.110642

Weakly Solvating Hydrated Eutectic Electrolyte for High-Performance Aluminum-Ion Batteries with Wide Temperature Range

Journal of the American Chemical Society Yuzhao Xu, Yixin Li, Qi Zhang et al. Oct 01, 2025 DOI: 10.1021/jacs.5c08778