Browse Articles
Discover research articles across all indexed journals
Cryopreserved leukapheresis enables scalable and distributed CAR-T manufacturing: a multi-platform comparative study
Improving CNN predictive accuracy in COVID-19 health analytics
An intelligent object detection and classification framework for assisting visually challenged persons using deep learning and improved crow search optimization
Reference intervals for leukocyte cell population data in healthy adults in Zigong region, China
Six questions to ask before jumping into a spreadsheet
Characterization of prokaryotic plankton community structure in the Southern East China Sea using combined 16S-rDNA and 16S-rRNA
Effects of various static calibration postures on knee mechanics during locomotor tasks using statistical parametric mapping analysis
C to U RNA editing of MFN1 is regulated by ADARB1 and associates with favourable prognosis in chronic lymphocytic leukemia
Abstract Cytidine to uridine (C-to-U) as well as adenosine to inosine (A-to-I) RNA editing denotes the posttranscriptional modification of RNA by specialized RNA deaminases. As RNA editing alters the sequence of the RNA, it can affect splicing, stability, miRNA binding and may also lead to recoding of the translated protein. Recently, we analysed recoding A-to-I RNA editing in chronic lymphocytic leukaemia (CLL) and could define prognostically relevant editing patterns. However, disease relevant C-to-U RNA editing in CLL remained unexplored. In this study, we examined C-to-U RNA editing in CLL and discovered a recoding RNA editing site within the MFN1 gene (hg38; chr3:179,375,230), which has recently been described as RNA editing site in brain samples. We found that MFN1 editing was not only present in CLL samples but also in naive B cell subsets, primarily occurred at unspliced RNA and correlated with intron retention. We further identified catalytically active ADARB1 as an essential regulator for MFN1 editing. Finally, MFN1 editing correlated with prolonged time to treatment and overall survival in CLL patients. Summarizing, we identified a novel ADARB1 function as C to U editing regulator, which regulates MFN1 splicing and MFN1 S329L recoding with pathogenic relevance in CLL.
Mediating role of online academic emotions between online presence and learning performance in blended learning environments
Decolonize scientific institutions, don’t just diversify them
Machine learning model to predicting synergy of ultrasonication and solvation impacts on crude oil viscosity
How animal paw pads got their toughness
FGF21 is a novel biomarker to predict fragility fractures in patients with type 2 diabetes mellitus
Health-related quality of life related to diabetes multisensory deficits and derealization
Dynamical behavior of analytical solutions and bifurcation analysis for a novel structured (2+1)-dimensional Kadomtsev-Petviashvili equation via analytic approach
Monoclonal antibodies revolutionized biomedical science and health care
Extracellular bioelectrical lexicon: detecting rhythmic patterns within dermal fibroblast populations
Abstract This study uses a bioelectronic-based method to establish how non-electrogenic cells, like dermal fibroblast, employ bioelectrical signals to convey information. Electrophysiology using large-area Multielectrode Arrays (MEAs) devices revealed how populations of non-electrogenic cells in vitro generate patterns of bioelectrical signals. The period of the bioelectrical patterns depends on cell population activity. In a fully formed, healthy monolayer, bioelectrical activity is minimal. But during the formation of a monolayer, signals appear randomly, with a dominant period of 4.2 min. Occasionally, quasi-periodic bursts occur with a period between 1.6 and 2 min. When a mechanical wound is inflicted and during subsequent monolayer repair, quasi-periodic signal bursts occur, with an average period ranging from 60 to 110 min. The study uncovers a short-range non humoral communication system and a lexicon of bioelectrical signals linked to cell states.