Browse Articles

Protracted late Paleozoic volcanic arc activity along the Northeast Asian continental margin

FAD synthase confers ferroptosis resistance and restrains CD8+ T cell recruitment in hepatocellular carcinoma

hADMSC-YTZP seeding improves peri-implant bone repair through increased expression of BMP-2, ALP, and OPG

Chromatin profiling identifies putative dual roles for H3K27me3 in regulating cell type-specific genes and transposable elements in choanoflagellates

Identification and emergy quantification methods of water shortage loss in regional water use system under extreme drought conditions

Mixed Ionic–Covalent Bonds Achieve Durable Acidic Water Oxidation

Global estimates of seagrass blue carbon stocks in biomass and net primary production

Improving solar panel performance using a paraffin wax/copper oxide nanoparticle hybrid phase change material

Highly Selective and Stable Covalent Organic Framework Electrocatalysts for Sustainable Chlorine Evolution

epDevAtlas: mapping GABAergic cells and microglia in the early postnatal mouse brain

Abstract During development, brain regions follow encoded growth trajectories. Compared to classical brain growth charts, high-definition growth charts could quantify regional volumetric growth and constituent cell types, improving our understanding of typical and pathological brain development. Here, we create high-resolution 3D atlases of the early postnatal mouse brain, using Allen CCFv3 anatomical labels, at postnatal days (P) 4, 6, 8, 10, 12, and 14, and determine the volumetric growth of different brain regions. We utilize 11 different cell type-specific transgenic animals to validate and refine anatomical labels. Moreover, we reveal region-specific density changes in γ-aminobutyric acid-producing (GABAergic) neurons, cortical layer-specific cell types, and microglia as key players in shaping early postnatal brain development. We find contrasting changes in GABAergic neuronal densities between cortical and striatal areas, stabilizing at P12. Moreover, somatostatin-expressing and vasoactive intestinal peptide-expressing cortical interneurons undergo regionally distinct density changes. Remarkably, microglia transition from high density in white matter tracks to gray matter at P10, and show selective density increases in sensory processing areas that correlate with the emergence of individual sensory modalities. Lastly, we create an open-access web-visualization ( https://kimlab.io/brain-map/epDevAtlas ) for cell-type growth charts and developmental atlases for all postnatal time points.

Applying turbidity as a witness of the vulnerability of a ria to meteorological changes and anthropogenic interventions

1D Silver Organochalcogenide Semiconductors: Color Tunable Luminescence, Polarized Emission, and Long-Range Exciton Diffusion

A highly accurate risk factor-based XGBoost multiethnic model for identifying patients with skin cancer

Abstract While individuals of European descent have a higher risk of skin cancer, other ancestries tend to have more advanced disease at diagnosis, resulting in outcome disparities. We examine the diverse All of Us dataset and identify genetic ancestries, lifestyle, social determinants of health and PDE5a inhibitor use as independent risk factors for skin cancer. We integrate these risk factors into a highly accurate XGBoost multiethnic model for identifying patients with skin cancer. Analyses of Shapley scores and interactions indicate the presence of strong non-linear associations between age and other risk factors, in particular cancer history, genetic ancestry and annual income, and suggest a stronger dependence on genetic and social determinants in younger individuals. Our XGBoost multiethnic model offers a precision medicine approach for early skin cancer detection in ethnically diverse patients, which could reduce outcome disparities in individuals of non-European ancestries.

Replacing soybean meal with distillers dried grains solubles on growth performance and feed utilization in catfish Clarias magur fingerlings

Anfinsen Redux: Ribonuclease Folding in the Single-Molecule Regime

Catalytic asymmetric synthesis of (N, N)- spiroketal via Pd-catalyzed enantioconvergent aminocarbonylation and dearomative nucleophilic aza-addition

Experimental investigation and ANN-based prediction of average Nusselt number for a flat surface subjected to double inclined air jets

Molecular ‘glues’ and ‘bumpers’ on receptors can bias signalling inside the cell

Molecular mechanism of co-transcriptional H3K36 methylation by SETD2

Abstract H3K36me3 is a hallmark of actively and recently transcribed genes and contributes to cellular memory and identity. The deposition of H3K36me3 occurs co-transcriptionally when the methyltransferase SETD2 associates with RNA polymerase II. Here we present three cryo-EM structures of SETD2 bound to RNA polymerase II elongation complexes at different states of nucleosome passage. Together with functional probing, our results suggest a 3-step mechanism of transcription-coupled H3K36me3 deposition. First, binding to the elongation factor SPT6 tethers the catalytic SET domain in proximity to the upstream DNA. Second, RNA polymerase II nucleosome passage leads to the transfer of a hexasome from downstream to upstream, poised for methylation. Finally, continued transcription leads to upstream nucleosome reassembly, partial dissociation of the histone chaperone FACT and sequential methylation of both H3 tails, completing H3K36me3 deposition of an upstream nucleosome after RNA polymerase II passage.

Public perception of environmental sanitation regulations on solid waste management in Owo and Akure cities, Ondo State, Nigeria