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Evolution of Hydrogen-Bonding Networks in Glycerol Dimer and Trimer: How Close Are They to Water Clusters?

The influence of cyclic loading-unloading rates on the uniaxial mechanical anisotropy of coal

Ligand Electronic Properties Dictate Composition of Ni-Based Nanocrystals

Pro‑inflammatory insulin‑resistant lipid phenotype in down syndrome identified by 1H‑NMR metabolomics in obesity-matched African‑American children and young adults

Degradation of Postconsumer Thermoset Rubbers via Photo-Oxidation

Soliton dynamics of the fourth-order nonlinear Boussinesq equation arising in shallow-water via advanced analytical techniques

Long-Term Operando Quantification of Li Plating on Graphite Anodes

Fine tuning wheat heading time through genome editing of transcription factor binding sites in Ppd-1 gene promoter

Abstract Increasing the productivity and adaptability of agricultural plants often depends on optimizing heading time. To develop common wheat lines with accelerated heading and investigate its regulation, we targeted the PPD-1 genes, which control photoperiod sensitivity. Large deletions in the promoter regions of these genes are known to disrupt their expression, resulting in early heading. Using CRISPR/Cas9 genome editing, we generated wheat plants with mutations in the promoter regions of the Ppd-D1 and Ppd-B1 genes. These mutations included nucleotide substitutions, deletions, and insertions ranging from several to hundreds of base pairs, occurring within probable transcription factor binding sites, that may influence gene expression. Under short-day conditions, we assessed PPD-1 gene expression in T0 plants and T2 lines with different mutations. Our analysis revealed that deletions spanning the CHE transcription repressor binding sites altered gene expression patterns, supporting the hypothesis regarding the role of these cis-elements in regulating PPD-1 expression. Furthermore, plants with different mutations displayed distinct diurnal expression patterns, suggesting the involvement of additional transcription factors in the regulation of this gene. Evaluation of heading time in T1 and T2 families with different mutations demonstrated that plants with mutations affecting the “core region”, including the CHE binding sites, initiated heading significantly earlier than those without mutations.

Enhancing smart city mobility through real time explainable AI in autonomous vehicles

Protein and Solvent Reorganization Drives Radical Pair Stability in Avian Cryptochrome 4a

Predicting flexural strength in fiber-reinforced UHPC via random forest

Bimetallic Relay Catalysis for Radical Hydrofunctionalization of Alkenes with Diverse Nucleophiles

Effect of early goal directed mobilization on clinical outcomes in mechanically ventilated ICU patients

Chemical Tagging of <i>N</i> -Alkylamine-Containing Natural Products and Pharmaceuticals through C( <i>sp</i> ³ )–H Functionalization

Coastal wetland deposition of cathode metals from the world’s largest lithium-ion battery fire

Laterally π-Extended Polyhelicenes

Contemporary architectural aesthetic preferences based on popular AI images and models of the Civitai architect community

1,2,3,4-Tetrasubstituted Chiral η ⁶ -Benzene Ligand: Design and Application in Ruthenium-Catalyzed Asymmetric Synthesis of Tertiary Indenols via C–H Activation

Exploring the links between sleep quality and stroke risk in older adults

Abstract The aging population faces significant health challenges, with sleep disturbances emerging as a critical yet often overlooked issue. Poor sleep quality is associated with various adverse health outcomes, including higher risks of mental health disorders and cerebrovascular events such as stroke. Understanding the relationships between sleep health, mental health, and stroke risk is essential for developing effective interventions. This study employed a cross-sectional design involving older adults to examine the associations among sleep disturbances, mental health (specifically depressive symptoms), and stroke risk. Participants completed validated questionnaires assessing sleep quality and depressive symptoms. Multivariate logistic regression and structural equation modeling were employed to analyze the data. The analysis revealed that older adults with difficulty falling asleep faced a significantly increased risk of stroke. Additionally, depressive symptoms were found to mediate the relationship between sleep disturbances and stroke risk. These findings highlight the interconnectedness of sleep health and mental health, demonstrating that poor sleep can contribute to higher rates of depression, which in turn increases stroke risk. The results underscore the importance of prioritizing sleep health in clinical practice for older adults. Addressing sleep disturbances is crucial not only for reducing stroke risk but also for enhancing overall well-being. Future research should further investigate the underlying mechanisms, consider sociocultural factors influencing sleep health, and develop targeted interventions to improve both sleep and mental health in this vulnerable population.

Selective and Scalable Aldehyde Production via Partial Oxidation of Alcohols in Acidic Media