Browse Articles

Role of thalamus in human conscious perception revealed by low-intensity focused ultrasound neuromodulation

TRPM4 expression predicts prognosis and modulates the immune microenvironment in pancreatic adenocarcinoma

An improved chaos control with adaptive active set approach combined in reliability-based design optimization

Quantification and prediction of solidification textures under additive manufacturing conditions

Identifying predictors of surgical site infection in closed patellar fracture surgery: a multicenter study

A supported decision-making model for idiopathic pulmonary fibrosis based on feature screening and optimized neural network

Using metagenomics and whole-genome sequencing to characterize enteric pathogens across various sources in Africa

Abstract Foodborne diseases (FBDs) remain a major public health concern in low- and middle-income countries (LMICs), with the African region carrying the heaviest burden globally. Surveillance efforts in these settings often overlook rural and resource-limited communities, limiting our understanding of pathogens transmission dynamics in these settings. In this study, we use whole-genome sequencing (WGS) and metagenomic approaches to characterize enteric pathogens from human, animal, and environmental sources across four African LMICs between 2019 and 2023. We analyze 446 bacterial isolates of Salmonella , Shigella , Escherichia coli , and Campylobacter , of which 380 high-quality genomes were subjected to phylogenetic and genotypic analyses. Additionally, 139 of 168 metagenomic samples pass quality control and were assessed for pathogen abundance and diversity. Our results reveal a geographically stable distribution of foodborne pathogens over time, suggesting persistent ecological or infrastructural factors influencing their maintenance. Genomic comparisons also identify closely related isolates across distinct sources and regions, pointing to potential transmission routes. These findings highlight the value of incorporating targeted environmental and food-chain sampling into surveillance strategies and demonstrate that metagenomic sequencing can serve as a practical and informative addition to WGS-based surveillance in resource-limited settings.

Screening of key genes related to disulfidptosis in psoriasis based on the analysis of WGCNA

Enhanced glycolysis and nicotinamide metabolism in HPV-positive head and neck cancer

Silicate chemical weathering disrupts the global patterns of phosphorus limitation

E-cigarette exposure and CDP choline modulate withdrawal- induced anxiety and hormonal levels in rats

Potentially toxic metals, source apportionment, meteorological impacts and health risks assessment of fine particulate matter (PM2.5) over Ilorin, Nigeria

CYFIP1 governs the development of cortical axons by modulating calcium availability

Abstract The human CYFIP1 gene is linked to Autism Spectrum Disorder (ASD) and Schizophrenia (SCZ), both associated with brain connectivity defects and corpus callosum abnormalities. Previous studies demonstrated that Cyfip1 -heterozygous mice exhibit diminished bilateral functional connectivity and callosal defects—resembling observations in ASD and SCZ patients. Here, we demonstrate that CYFIP1 is crucial for cortical axonal development and identify insufficient calcium uptake as the pivotal mechanism. In vivo , Cyfip1 heterozygosity delays callosal axon growth and arborization. Additionally, Cyfip1 -deficient cortical neurons and axons have reduced intracellular calcium, along with impaired mitochondria morphology, activity, and motility. Mechanistically, CYFIP1 binds and stabilises the mRNA of specific voltage-gated calcium channel subunits, explaining the decreased calcium concentration in Cyfip1 +/- cells. Notably, elevating intracellular calcium rescues delayed axonal growth and mitochondrial defects in Cyfip1 -deficient neurons. These findings highlight that, by regulating mRNA metabolism, CYFIP1 ensures proper callosal development, offering insights into brain connectivity disruptions underlaying neurodevelopmental disorders.

Optimized PV fed sensorless BLDC motor control system using Q-recurrent adaptive controller and Levy-enhanced circular search mechanisms

Improving women football tactics analysis by using extreme learning and accumulated optimization algorithm

NEK7 couples SDHB to orchestrate respiratory chain electron transport homeostasis that impedes liver fibrosis

Abstract The mode of electron transport in mitochondrial respiratory chain determines whether it generates energy or more reactive oxygen species (ROS), a key for cellular adaptation to diverse oxygen environments. However, the understanding of the mechanisms remains incomplete. Here, we find that NIMA-related kinase 7 (NEK7), targeted to mitochondria by its signal peptides, binds to succinate dehydrogenase complex iron sulfur subunit B (SDHB), stabilizing the spatial conformation of complex II and promoting forward electron transport. Deficiency of NEK7 in hepatocytes induces reverse electron transport (RET) and inhibits mitochondrial respiration, thereby promoting ROS generation, triggering spontaneous liver fibrosis and aggravating CCl 4 -induced liver fibrosis, which can be attenuated by RET inhibitors. More importantly, NEK7 overexpression effectively alleviates CCl 4 - and choline-deficient, high-fat diet-induced liver fibrosis. Overall, these findings highlight the pivotal role of NEK7 in orchestrating complex II and electron transport, providing new insights into the regulation of mitochondrial homeostasis and potential fibrosis treatments.

Cardiorespiratory fitness and cardiometabolic health are associated with distinct cognitive domains in cognitively healthy older adults

Abstract Cardiometabolic risk and low cardiorespiratory fitness have been linked to age-related cognitive decline, but their relative contributions to different cognitive domains remain unclear. This study examined cross-sectional associations between cardiometabolic health, cardiorespiratory fitness, and cognition in cognitively healthy older adults (60–70 years). Structural equation modelling (SEM) was used to estimate latent variables for cardiorespiratory fitness (derived from physical activity, resting heart rate and BMI), cardiometabolic health (derived from blood pressure, glucose, lipids and BMI), and four cognitive domains: processing speed, executive function, verbal memory, and crystallized ability. Better cardiorespiratory fitness was significantly associated with higher executive function and processing speed, but not with verbal memory or crystallized ability. In contrast, better cardiometabolic health was significantly associated with higher crystallized ability and verbal memory, but not with executive function or processing speed. These modest but reliable relationships remained significant when both health factors were included in the same model, suggesting a double dissociation between their cognitive correlates. This study provides the first evidence that cardiorespiratory fitness and cardiometabolic health are related to distinct aspects of cognition in later life, highlighting potential targets for lifestyle-based interventions to support cognitive health in older age.

Designing a neuro-symbolic dual-model architecture for explainable and resilient intrusion detection in IoT networks

Identifying global marine climate refugia through a conservative approach to ocean biodiversity preservation

Multimodal sleep management reduces perioperative insomnia in general surgery patients through optimal healing environments